Ehrlichia chaffeensis TRP47 enters the nucleus via a MYND-binding domain-dependent mechanism and predominantly binds enhancers of host genes associated with signal transduction, cytoskeletal organization, and immune response.

Autor: Kibler, Clayton E.¹, Milligan, Sarah L.¹, Farris, Tierra R.², Zhu, Bing¹, Mitra, Shubhajit¹, McBride, Jere W.^1,2,3,4,5 jemcbrid@utmb.edu

Publikováno v: PLoS ONE. 11/9/2018, Vol. 13 Issue 11, p1-21. 21p.

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Ehrlichia chaffeensis TRP120-mediated ubiquitination and proteasomal degradation of tumor suppressor FBW7 increases oncoprotein stability and promotes infection.

Autor: Wang JY; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America., Zhu B; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America., Patterson LL; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America., Rogan MR; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America., Kibler CE; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America., McBride JW; Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America.; Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.; Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, United States of America.; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, Texas, United States of America.; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2020 Apr 30; Vol. 16 (4), pp. e1008541. Date of Electronic Publication: 2020 Apr 30 (Print Publication: 2020).