Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kibibi Ganz"'
Autor:
John P. Cassady, Ana C. D’Alessio, Sovan Sarkar, Vardhan S. Dani, Zi Peng Fan, Kibibi Ganz, Reinhard Roessler, Mriganka Sur, Richard A. Young, Rudolf Jaenisch
Publikováno v:
Stem Cell Reports, Vol 3, Iss 6, Pp 948-956 (2014)
Overexpression of transcription factors has been used to directly reprogram somatic cells into a range of other differentiated cell types, including multipotent neural stem cells (NSCs), that can be used to generate neurons and glia. However, the abi
Externí odkaz:
https://doaj.org/article/ff877594372543e19efc4c16d32654c6
Autor:
Yueh-Chiang Hu, Dongdong Fu, David C. Page, G. Grant Welstead, Albert W. Cheng, Yosef Buganim, Sovan Sarkar, Kibibi Ganz, Rudolf Jaenisch, Elena Itskovich
Publikováno v:
Cell Stem Cell. 11(3):373-386
SummarySertoli cells are considered the “supporting cells” of the testis that play an essential role in sex determination during embryogenesis and in spermatogenesis during adulthood. Their essential roles in male fertility along with their immun
Autor:
Sandy Klemm, Kibibi Ganz, Yosef Buganim, Elena Itskovich, Alexander van Oudenaarden, Styliani Markoulaki, Dina A. Faddah, Albert W. Cheng, Rudolf Jaenisch
Publikováno v:
Cell, 150(6), 1209-1222. Elsevier B.V.
SummaryDuring cellular reprogramming, only a small fraction of cells become induced pluripotent stem cells (iPSCs). Previous analyses of gene expression during reprogramming were based on populations of cells, impeding single-cell level identificatio
Autor:
Styliani Markoulaki, Meelad M. Dawlaty, Jongpil Kim, Qing Gao, Yueh-Chiang Hu, Kibibi Ganz, Sang-Woon Choi, Rudolf Jaenisch, Albert W. Cheng, David C. Page, Benjamin E. Powell
Publikováno v:
Cell Stem Cell. 9(2):166-175
Summary The Tet family of enzymes (Tet1/2/3) converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Mouse embryonic stem cells (mESCs) highly express Tet1 and have an elevated level of 5hmC. Tet1 has been implicated in ESC maintenance and
Autor:
Haoyi Wang, Benjamin E. Powell, Meelad M. Dawlaty, Ana C. D’Alessio, Richard A. Young, Maya Mitalipova, Nathanael S. Gray, Dina A. Faddah, Thorold W. Theunissen, Dorothea Maetzel, Zi Peng Fan, Jessica Reddy, Kibibi Ganz, Qing Gao, Sumeth Imsoonthornruksa, Linyu Shi, Rudolf Jaenisch, Tenzin Lungjangwa, Yonatan Stelzer, Jianming Zhang, Sudharshan Rangarajan
Publikováno v:
Cell Stem Cell
Summary Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological characteristics, raising the question of whether an earlier, “naive” state of pluripotency may exist in humans. Here we took a systematic approach to id
Autor:
Matthew D. Schultz, Qing Gao, Kibibi Ganz, Rudolf Jaenisch, Richard A. Young, Linyu Shi, Styliani Markoulaki, Yupeng He, Joseph R. Ecker, Yosef Buganim, Tao Wu, Andrew Xiao, Heather A. Hoke, Batool Akhtar-Zaidi, Malkiel A. Cohen, Brian J. Abraham, David Porubsky, Elisabeth Kulenkampff, Johanna Goldmann, Joseph R. Nery, Sovan Sarkar, Niek van Wietmarschen, Peter M. Lansdorp, Dina A. Faddah
Publikováno v:
PMC
Cell Stem Cell
Cell stem cell, 15(3), 295-309. CELL PRESS
Cell Stem Cell
Cell stem cell, 15(3), 295-309. CELL PRESS
Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4, Sox2, Klf4, and Myc (OSKM) into cells. Although iPSCs are pluripotent, they frequently exhibit high variation in terms of quality, as measured in mice by chimera c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e4be53fffc7276d068d046eb60f786
http://hdl.handle.net/1721.1/109508
http://hdl.handle.net/1721.1/109508
Autor:
Qing Gao, G. Grant Welstead, Bryce W. Carey, Eveline J. Steine, Menno P. Creyghton, Jacob H. Hanna, Kibibi Ganz, John P. Cassady, Dina A. Faddah, Jongpil Kim, Rudolf Jaenisch, Styliani Markoulaki, Yosef Buganim
Publikováno v:
Cell Stem Cell, 9(6), 588-598. Cell Press
SummaryWe compared two genetically highly defined transgenic systems to identify parameters affecting reprogramming of somatic cells to a pluripotent state. Our results demonstrate that the level and stoichiometry of reprogramming factors during the