Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kibaick Lee"'
Autor:
Song Cheol Kim, Song Lee, In-Uk Koh, Nak-Hyeon Choi, Kibaick Lee, Ho-Yeong Yu, Jun Ho Yun, Jin-Hwa Kong, Sanghoon Moon
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
Introduction Obesity is growing global health concern and highly associated with increased risk of metabolic diseases including type 2 diabetes. We aimed to discover new differential DNA methylation patterns predisposing obesity and prioritize surrog
Externí odkaz:
https://doaj.org/article/b4d41dac67c24258a09c74a5f967526a
Autor:
Kibaick Lee, Sanghoon Moon, Mi-Jin Park, In-Uk Koh, Nak-Hyeon Choi, Ho-Yeong Yu, Young Jin Kim, Jinhwa Kong, Hee Gyung Kang, Song Cheol Kim, Bong-Jo Kim
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 14, p 5056 (2020)
This study investigated whether the promoter region of DNA methylation positively or negatively regulates tissue-specific genes (TSGs) and if it correlates with disease pathophysiology. We assessed tissue specificity metrics in five human tissues, us
Externí odkaz:
https://doaj.org/article/96458080a4e9481993d1df48610139f0
Publikováno v:
Genomics & Informatics, Vol 13, Iss 2, Pp 40-44 (2015)
DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic signatures. In particular, chro
Externí odkaz:
https://doaj.org/article/805bd598494847efbcc3da4e8f18da97
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175768 (2017)
Genome-wide association studies (GWASs) have identified a large number of noncoding associations, calling for systematic mapping to causal regulatory variants and their distal target genes. A widely used method, quantitative trait loci (QTL) mapping
Externí odkaz:
https://doaj.org/article/20caff10aef84f89bebd1efec4430eb2
Autor:
Kibaick Lee, Sang Cheol Kim, Inkyung Jung, Kwoneel Kim, Jungmin Seo, Heun-Sik Lee, Gireesh K Bogu, Dongsup Kim, Sanghyuk Lee, Byungwook Lee, Jung Kyoon Choi
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003229 (2013)
Chromatin regulation underlies a variety of DNA metabolism processes, including transcription, recombination, repair, and replication. To perform a quantitative genetic analysis of chromatin accessibility, we obtained open chromatin profiles across 9
Externí odkaz:
https://doaj.org/article/f394353baf1748348545bc781d8d14b0
Publikováno v:
PLoS Genetics, Vol 9, Iss 9, p e1003778 (2013)
Regulatory regions maintain nucleosome-depleted, open chromatin status but simultaneously require the presence of nucleosomes for specific histone modifications. It remains unclear how these can be achieved for proper regulatory function. Here we dem
Externí odkaz:
https://doaj.org/article/e16efedcee8545d09625c769c1a016b2
Autor:
Jun Ho Yun, Nak-Hyeon Choi, Bong-Jo Kim, Jinhwa Kong, Song Cheol Kim, Hyo Jin Kim, Ho-Yeong Yu, Kibaick Lee, Sanghoon Moon, In-Uk Koh, Song Lee
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
BMJ Open Diabetes Research & Care
BMJ Open Diabetes Research & Care
IntroductionObesity is growing global health concern and highly associated with increased risk of metabolic diseases including type 2 diabetes. We aimed to discover new differential DNA methylation patterns predisposing obesity and prioritize surroga
Autor:
Young-Jin Kim, Hee Gyung Kang, Ho Yeong Yu, Nak Hyeon Choi, Kibaick Lee, Sanghoon Moon, Bong Jo Kim, Mi Jin Park, Jinhwa Kong, In Uk Koh, Song Cheol Kim
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 14
International Journal of Molecular Sciences, Vol 21, Iss 5056, p 5056 (2020)
Volume 21
Issue 14
International Journal of Molecular Sciences, Vol 21, Iss 5056, p 5056 (2020)
This study investigated whether the promoter region of DNA methylation positively or negatively regulates tissue-specific genes (TSGs) and if it correlates with disease pathophysiology. We assessed tissue specificity metrics in five human tissues, us
Publikováno v:
PLOS ONE(12): 4
PLoS ONE
PLoS ONE, Vol 12, Iss 4, p e0175768 (2017)
PLoS ONE
PLoS ONE, Vol 12, Iss 4, p e0175768 (2017)
Genome-wide association studies (GWASs) have identified a large number of noncoding associations, calling for systematic mapping to causal regulatory variants and their distal target genes. A widely used method, quantitative trait loci (QTL) mapping
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2fb1d0bf413716ff9e29a8e9876f727
http://open-repository.kisti.re.kr/cube/handle/open_repository/483480.do
http://open-repository.kisti.re.kr/cube/handle/open_repository/483480.do
Publikováno v:
Methods (San Diego, Calif.). 102
As a final function of various epigenetic mechanisms, chromatin regulation is a transcription control process that especially demonstrates active interaction with genetic elements. Thus, chromatin structure has become a principal focus in recent geno