Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Kiaran, Kirk"'
Autor:
Deyun Qiu, Jinxin V. Pei, James E. O. Rosling, Vandana Thathy, Dongdi Li, Yi Xue, John D. Tanner, Jocelyn Sietsma Penington, Yi Tong Vincent Aw, Jessica Yi Han Aw, Guoyue Xu, Abhai K. Tripathi, Nina F. Gnadig, Tomas Yeo, Kate J. Fairhurst, Barbara H. Stokes, James M. Murithi, Krittikorn Kümpornsin, Heath Hasemer, Adelaide S. M. Dennis, Melanie C. Ridgway, Esther K. Schmitt, Judith Straimer, Anthony T. Papenfuss, Marcus C. S. Lee, Ben Corry, Photini Sinnis, David A. Fidock, Giel G. van Dooren, Kiaran Kirk, Adele M. Lehane
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
In a recent clinical trial for oral administration of cipargamin in individuals with malaria, there was an emergence of recrudescent parasites with a G358S mutation in PfATP4. In this work, the authors investigate the effect of this mutation on the f
Externí odkaz:
https://doaj.org/article/7abacde286514d8b929ffa3fbc4d3a0f
Autor:
Kiaran Kirk, John Richards
Even before University House was opened in 1954, a House Wine Committee had been formed, leading to the 1st University House Wine Symposium, held in 1956. These proceedings record the 7th University House Wine Symposium, held in 2011 to commemorate t
Autor:
Joy M. Zeng, Sanduni V. Hapuarachchi, Sarah H. Shafik, Rowena E. Martin, Kiaran Kirk, Giel G. van Dooren, Adele M. Lehane
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Toxoplasma gondii and Plasmodium falciparum parasites both extrude l-lactate, a byproduct of glycolysis. The P. falciparum Formate Nitrite Transporter, PfFNT, mediates l-lactate transport across the plasma membrane of P. falciparum parasites
Externí odkaz:
https://doaj.org/article/2487d4ef217541f185f3c2fd767c2794
Autor:
Stephen J Fairweather, Esther Rajendran, Martin Blume, Kiran Javed, Birte Steinhöfel, Malcolm J McConville, Kiaran Kirk, Stefan Bröer, Giel G van Dooren
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009835 (2021)
Intracellular parasites of the phylum Apicomplexa are dependent on the scavenging of essential amino acids from their hosts. We previously identified a large family of apicomplexan-specific plasma membrane-localized amino acid transporters, the ApiAT
Externí odkaz:
https://doaj.org/article/53e61d32b3994dd4b73f4ec8560f0c98
Autor:
Esther Rajendran, Morgan Clark, Cibelly Goulart, Birte Steinhöfel, Erick T Tjhin, Simon Gross, Nicholas C Smith, Kiaran Kirk, Giel G van Dooren
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009816 (2021)
Intracellular parasites, such as the apicomplexan Toxoplasma gondii, are adept at scavenging nutrients from their host. However, there is little understanding of how parasites sense and respond to the changing nutrient environments they encounter dur
Externí odkaz:
https://doaj.org/article/e6aa59b199ac4fd4be72d45596137ba1
Autor:
Esther Rajendran, Sanduni V. Hapuarachchi, Catherine M. Miller, Stephen J. Fairweather, Yeping Cai, Nicholas C. Smith, Ian A. Cockburn, Stefan Bröer, Kiaran Kirk, Giel G. van Dooren
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Apicomplexans are parasites that use membrane transporters to scavenge essential nutrients from the host. Here the authors identify and characterize two apicomplexans transporters showing that these are crucial for cationic amino acid uptake, parasit
Externí odkaz:
https://doaj.org/article/af9f4f91b04841bdb2ffbb97deef1228
Autor:
Kathryn E R Parker, Stephen J Fairweather, Esther Rajendran, Martin Blume, Malcolm J McConville, Stefan Bröer, Kiaran Kirk, Giel G van Dooren
Publikováno v:
PLoS Pathogens, Vol 15, Iss 2, p e1007577 (2019)
Apicomplexan parasites are auxotrophic for a range of amino acids which must be salvaged from their host cells, either through direct uptake or degradation of host proteins. Here, we describe a family of plasma membrane-localized amino acid transport
Externí odkaz:
https://doaj.org/article/957920499bae44ad99b67c789c303b4e
Autor:
Phuong N. Tran, Cameron J. Tate, Melanie C. Ridgway, Kevin J. Saliba, Kiaran Kirk, Alexander G. Maier
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 3, Pp 179-183 (2016)
Ketotifen has recently been reported to inhibit the growth of both asexual and sexual malaria parasites. A parasite transporter, PfgABCG2, has been implicated in its mechanism of action. Human dihydrofolate reductase (hDHFR) is the most commonly used
Externí odkaz:
https://doaj.org/article/bca708d4dc524a98acefd1eb8a9cff69
Autor:
Alice E. Williamson, Paul M. Ylioja, Murray N. Robertson, Yevgeniya Antonova-Koch, Vicky Avery, Jonathan B. Baell, Harikrishna Batchu, Sanjay Batra, Jeremy N. Burrows, Soumya Bhattacharyya, Felix Calderon, Susan A. Charman, Julie Clark, Benigno Crespo, Matin Dean, Stefan L. Debbert, Michael Delves, Adelaide S. M. Dennis, Frederik Deroose, Sandra Duffy, Sabine Fletcher, Guri Giaever, Irene Hallyburton, Francisco-Javier Gamo, Marinella Gebbia, R. Kiplin Guy, Zoe Hungerford, Kiaran Kirk, Maria J. Lafuente-Monasterio, Anna Lee, Stephan Meister, Corey Nislow, John P. Overington, George Papadatos, Luc Patiny, James Pham, Stuart A. Ralph, Andrea Ruecker, Eileen Ryan, Christopher Southan, Kumkum Srivastava, Chris Swain, Matthew J. Tarnowski, Patrick Thomson, Peter Turner, Iain M. Wallace, Timothy N. C. Wells, Karen White, Laura White, Paul Willis, Elizabeth A. Winzeler, Sergio Wittlin, Matthew H. Todd
Publikováno v:
ACS Central Science, Vol 2, Iss 10, Pp 687-701 (2016)
Externí odkaz:
https://doaj.org/article/389f0d71ee2a4fb79f8bb1da8028bfae
Autor:
Natalie Jane Spillman, Kiaran Kirk
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 5, Iss 3, Pp 149-162 (2015)
The intraerythrocytic malaria parasite, Plasmodium falciparum, maintains a low cytosolic Na+ concentration and the plasma membrane P-type cation translocating ATPase ‘PfATP4’ has been implicated as playing a key role in this process. PfATP4 has b
Externí odkaz:
https://doaj.org/article/37128bbed9c94bd4844e6fd5a083f365