Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kianga Schmuck"'
Autor:
Tapia, Carlos, Aritz Alonso, Ales Padró, Hugarte, Raul, Bianchi, Marco, López, Arantza, Pihkola, Hanna, Saarivuori, Elina, Ritthoff, Michael, Saling, Peter, Kianga Schmuck, Ywann Penru, Dauthuille, Pascal, Roeder, Alexander Martin, Jenke, Martin, Søreide, Jostein, Enström, Annamari, Kuusisto, Sari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0290e3b5aa97fdc2b1adf7bced87840a
Publikováno v:
Chemistry - A European Journal. 19:1726-1731
A main problem of common cancer chemotherapy is the occurrence of severe side effects caused by insufficient selectivity of the applied drugs. A possible concept to overcome this limitation is light-driven prodrug monotherapy. The synthesis as well a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec410b7b414a4c5c97a84fe77fd45d7
https://doi.org/10.1002/chem.201202773
https://doi.org/10.1002/chem.201202773
Publikováno v:
Angewandte Chemie International Edition. 51:2874-2877
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa2dce19e8ef127ea1f2707590fe441
https://doi.org/10.1002/anie.201106334
https://doi.org/10.1002/anie.201106334
Autor:
Kianga Schmuck, Lutz F. Tietze
Publikováno v:
Current Pharmaceutical Design. 17:3527-3547
The treatment of cancer with common anti-proliferative agents generally suffers from an insufficient differentiation between normal and malignant cells which results in extensive side effects. To enhance the efficacy and reduce the normal tissue toxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20afb93d241d73e1710754a834aa96ca
https://doi.org/10.2174/138161211798194459
https://doi.org/10.2174/138161211798194459
Autor:
Kianga Schmuck, Lutz F. Tietze
Publikováno v:
Synlett. 2011:1697-1700
We present a new highly potent building block for PET imaging based on silicon fluoride acceptors (SiFA) which can easily be coupled to bioactive compounds by means of click chemistry. Owing to a remarkable chemoselectivity, short reaction times, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bcd0e35ad98f3d1df938ef7ecf38240
https://doi.org/10.1055/s-0030-1260942
https://doi.org/10.1055/s-0030-1260942
Publikováno v:
Chemistry - A European Journal. 17:1922-1929
Chemotherapy of malign tumors is usually associated with serious side effects as common anticancer drugs lack selectivity. An approach to deal with this problem is the antibody-directed enzyme prodrug therapy (ADEPT) and the prodrug monotherapy (PMT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b3faf33b635f6eab0ae0f3a509e9769
https://doi.org/10.1002/chem.201002798
https://doi.org/10.1002/chem.201002798
Autor:
Lutz F. Tietze, Birgit Krewer, Ingrid Schuberth, J. Marian von Hof, Frauke Alves, Kianga Schmuck, Heiko J. Schuster
Publikováno v:
Organicbiomolecular chemistry. 8(8)
The synthesis of the first spacer containing, duocarmycin analogue prodrug 11 was realised, its biological properties evaluated and compared to its counterpart prodrug 2 without a spacer unit. The synthesis comprises the manufacture of the new acetyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8c5e179c1092ef752a059c575a65f3
https://pubmed.ncbi.nlm.nih.gov/20449487
https://pubmed.ncbi.nlm.nih.gov/20449487
Publikováno v:
Bioorganicmedicinal chemistry. 16(12)
The synthesis and biological evaluation of novel prodrugs based on the cytotoxic antibiotic duocarmycin SA (1) for a selective treatment of cancer using a prodrug monotherapy (PMT) are described. Transformation of the phenol 8 with the glucuronic aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5cc729227ed56ce47e2fd7f69dc640c
https://pubmed.ncbi.nlm.nih.gov/18524605
https://pubmed.ncbi.nlm.nih.gov/18524605
Publikováno v:
Tetrahedron Letters. 47:8769-8770
A new synthetic route for the synthesis of betulinic acid from betulin has been developed. The main step of this procedure is the selective oxidation of the primary alcohol function of betulin without affecting the secondary hydroxyl group. Applying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bdde0f4eb8d185e68baddfb2f089e0a
https://doi.org/10.1016/j.tetlet.2006.10.004
https://doi.org/10.1016/j.tetlet.2006.10.004