Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Kiana Guerrazzi"'
Autor:
Andrea C Florian, Chase M Woodley, Jing Wang, Brian C Grieb, Macey J Slota, Kiana Guerrazzi, Chih-Yuan Hsu, Brittany K Matlock, David K Flaherty, Shelly L Lorey, Stephen W Fesik, Gregory C Howard, Qi Liu, April M Weissmiller, William P Tansey
Publikováno v:
NAR Cancer. 4
Rhabdoid tumors (RT) are rare and deadly pediatric cancers driven by loss of SMARCB1, which encodes the SNF5 component of the SWI/SNF chromatin remodeler. Loss of SMARCB1 is associated with a complex set of phenotypic changes including vulnerability
Autor:
Alissa D. Guarnaccia, Christina E. Wang, April M. Weissmiller, Jing Wang, William P. Tansey, William G. Payne, Kristie L. Rose, Kiana Guerrazzi, J. Grace Shaw, Edward T. Olejniczak, Salisha Hill, Tessa M. Popay, Stephen W. Fesik, Chase M Woodley, Qi Liu, Tyler J. Hansen, Bin Zhao, Shelly L. Lorey
Publikováno v:
Cell reports
SUMMARY The chromatin-associated protein WDR5 is a promising pharmacological target in cancer, with most drug discovery efforts directed against an arginine-binding cavity in WDR5 called the WIN site. Despite a clear expectation that WIN site inhibit