TRIM37 controls cancer-specific vulnerability to PLK4 inhibition

Autor: Kian-Yong Lee, Andrew K. Shiau, Sadanori Watanabe, Karen Oegema, Franz Meitinger, Ruth Kabeche, John V. Anzola, Robert L. Davis, Arshad Desai, David A. Jenkins, Midori Ohta

Publikováno v: Nature, vol 585, iss 7825
Nature

Centrosomes catalyse the formation of microtubules needed to assemble the mitotic spindle apparatus1. Centrosomes themselves duplicate once per cell cycle, in a process that is controlled by the serine/threonine protein kinase PLK4 (refs. 2,3). When

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56dfc8bc688d7c62c40c79d2210702f7
https://escholarship.org/uc/item/0pw1p3s3

Large scale commercial fabrication of high quality graphene-based assays for biomolecule detection

Autor: Lauren Locascio, Kian-Yong Lee, Karen Oegema, Savannah J. Afsahi, Mitchell Lerner, Philip G. Collins, Brett R. Goldsmith, Jolie Nokes, Deng Pan, Amy Walker, Jeremy Lerner, Francie Barron, Yingning Gao

Publikováno v: Sensors and Actuators B: Chemical. 239:1261-1267

Large numbers of high quality graphene transistors with mobility approximately 5000 cm 2 /V*s were fabricated by chemical vapor deposition and packaged into ceramic carriers with an open cavity design. The ceramic carrier is compatible with standard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::446b33220b02f18c1968984aefd087a7
https://doi.org/10.1016/j.snb.2016.09.137

Ancestral roles of the Fam20C family of secreted protein kinases revealed in

Autor: Adina, Gerson-Gurwitz, Carolyn A, Worby, Kian-Yong, Lee, Renat, Khaliullin, Jeff, Bouffard, Dhanya, Cheerambathur, Karen, Oegema, Erin J, Cram, Jack E, Dixon, Arshad, Desai

Publikováno v: The Journal of Cell Biology

Gerson-Gurwitz et al. show that FAMK-1, the sole Fam20-like secreted protein kinase in C. elegans, contributes to embryonic development and fertility, acts in the late secretory pathway, phosphorylates lectins, and is important in embryonic and tissu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bf95302599097924905d57d42a55e136
https://pubmed.ncbi.nlm.nih.gov/31541016

CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytia

Autor: Rebecca Green, Karen Oegema, Shaohe Wang, Edgar Gutierrez, Arshad Desai, J Sebastian Gomez-Cavazos, Irina Kolotuev, Alex Groisman, Kian-Yong Lee

Publikováno v: eLife
eLife, eLife Sciences Publication, 2018, 7, pp.e36919. ⟨10.7554/eLife.36919⟩
eLife, 2018, 7, pp.e36919. ⟨10.7554/eLife.36919⟩
eLife, Vol 7 (2018)

Throughout metazoans, germ cells undergo incomplete cytokinesis to form syncytia connected by intercellular bridges. Formation of gametes ultimately requires bridge closure. Here, we investigate the contribution of the conserved bridge component cent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95b63bbf61bcfc5c5becc83947593d7
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01862598

A Nucleoporin Docks Protein Phosphatase 1 to Direct Meiotic Chromosome Segregation and Nuclear Assembly

Autor: Kian-Yong Lee, Mark W. Moyle, Neil Hattersley, Dhanya K. Cheerambathur, Karen Oegema, Arshad Desai, Julien Dumont, Marine Stefanutti, Amelia Richardson

Publikováno v: Developmental Cell
Developmental Cell, Elsevier, 2016, 38 (5), pp.463-477. ⟨10.1016/j.devcel.2016.08.006⟩

International audience; During M-phase entry in metazoans with open mitosis, the concerted action of mitotic kinases disassembles nuclei and promotes assembly of kinetochores—the primary microtubule attachment sites on chromosomes. At M-phase exit,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c3f0829e734bcc1c1ccaf8d7aac43f
https://hal.archives-ouvertes.fr/hal-01472324