Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kian Chuan Sia"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8342 (2024)
Adeno-associated viruses (AAVs) have emerged as promising tools for gene therapy due to their safety and efficacy in delivering therapeutic genes or gene editing sequences to various tissues and organs. AAV serotype 9 (AAV9), among AAV serotypes, sta
Externí odkaz:
https://doaj.org/article/db498de78e5c411999c60f19c3377920
Publikováno v:
Cells, Vol 9, Iss 11, p 2474 (2020)
We have previously used a hepatotropic adeno-associated viral (AAV) vector with a modified human insulin gene to treat diabetic mice. The HLP (hybrid liver-specific promoter) used was constitutively active and non-responsive to glucose. In this study
Externí odkaz:
https://doaj.org/article/36140b25fe8f4692a27038cb298e2d6a
Autor:
Paula Yeng Po Lam, Kam Man Hui, Kiat Hon Lim, London Lucien Peng Jin Ooi, Alexander Yaw Fui Chung, Hung Huynh, Kian Chuan Sia
Gene regulation of many key cell-cycle players in S-, G2 phase, and mitosis results from transcriptional repression in their respective promoter regions during the G0 and G1 phases of cell cycle. Within these promoter regions are phylogenetically con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95af3918fdedb25d2f0177117c113c19
https://doi.org/10.1158/1535-7163.c.6536517.v1
https://doi.org/10.1158/1535-7163.c.6536517.v1
Autor:
Paula Yeng Po Lam, Kam Man Hui, Kiat Hon Lim, London Lucien Peng Jin Ooi, Alexander Yaw Fui Chung, Hung Huynh, Kian Chuan Sia
Supplementary Figure S1 - PDF file 87K, Gene expression of AH-6CC-L2C in proliferating and G1-arrested PLC/PRF/5 cells. Cell cycle-regulated luciferase reporter activity in proliferating and G1-arrested PLC/PRF/5 cells after 48 h in A, post transfect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bfd1dec0aa94a41d7faaa509f529626
https://doi.org/10.1158/1535-7163.22500630
https://doi.org/10.1158/1535-7163.22500630
Autor:
Paula Yeng Po Lam, Kam Man Hui, Kiat Hon Lim, London Lucien Peng Jin Ooi, Alexander Yaw Fui Chung, Hung Huynh, Kian Chuan Sia
Supplementary Figure Legends - PDF file 83K, Supplementary Figure legends for Figure S1, S2, S3, S4, S5, S6, S7 and S8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f3d7862e1b131cfba2de364dd401cd
https://doi.org/10.1158/1535-7163.22500633
https://doi.org/10.1158/1535-7163.22500633
Autor:
Paula Yeng Po Lam, Kam Man Hui, Kiat Hon Lim, London Lucien Peng Jin Ooi, Alexander Yaw Fui Chung, Hung Huynh, Kian Chuan Sia
Supplementary Materials and Methods - PDF file 94K, Supplementary Materials and Methods including helper virus-free packaging, isolation of single cells suspension, immunofluorescent (IF) staining, immunohistochemical (IHC) staining and cell cycle an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716c8eb612c35688a0ec1f6e4f868ed7
https://doi.org/10.1158/1535-7163.22500606.v1
https://doi.org/10.1158/1535-7163.22500606.v1
Autor:
Kian Chuan Sia, Shu Uin Gan, Siti Humairah Mohd Rodhi, Zhen Ying Fu, John J. Kopchick, Michael J. Waters, Kok Onn Lee
Publikováno v:
Gene therapy. 29(6)
The only treatment tested for growth hormone receptor (GHR) defective Laron Syndrome (LS) is injections of recombinant insulin-like-growth factor 1 (rhIGF1). The response is suboptimal and associated with progressive obesity. In this study, we treate
Autor:
Asha Recino, Nick Holmes, Rob Foale, Shu Uin Gan, Fiona M. Gribble, Kian Chuan Sia, Yvonne Sawyer, Anne Cooke, Maja Wallberg, Roy Y Calne, Kok Onn Lee, Frank Reimann, Amit C. Nathwani, Jenny Trendell, Maria Notaridou, Richard Kay, Andrew M. L. Lever
Publikováno v:
Gene Therapy
We report the restoration of euglycaemia in chemically induced diabetic C57BL/6 mice and spontaneously diabetic Non Obese Diabetic (NOD) mice by intravenous systemic administration of a single-stranded adeno-associated virus (ssAAV2/8) codon optimise
Autor:
Shou P. Guan, Kam M. Hui, Kian Chuan Sia, Siao T. Chong, Alexander Y. F. Chung, Berwini Endaya, Catherine Y. L. Kok, Jennifer P. Newman, Bin B. Liu, Paula Y.P. Lam, Hung Huynh
Publikováno v:
Oncotarget
The epithelial cell adhesion molecule (EpCAM) is a type I transmembrane glycoprotein that is regarded as one of the markers for tumor initiating cells (TIC) in human hepatocellular carcinoma (HCC). Much work has been directed towards targeting these
Autor:
Paula Y.P. Lam, Chang M. Guo, Ivy A.W. Ho, Kam M. Hui, Yulyana Yulyana, Jennifer P. Newman, Kian Chuan Sia
Publikováno v:
The FASEB Journal. 28:4359-4368
Human bone marrow-derived mesenchymal stem cells (MSCs) have the unique ability to home toward injuries or tumor sites. We have previously shown that the tumor-tropic property is dependent on the intrinsic expression and activity of the matrix remode