Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Kiakos K"'
Autor:
Garelnabi, Elrashied A.E., Pletsas, Dimitrios, Li, Li, Kiakos, K., Karodia, Nazira, Hartley, J.A., Phillips, Roger M., Wheelhouse, Richard T.
Yes
The imidazotetrazine ring is an acid-stable precursor and prodrug of highly reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% ef
The imidazotetrazine ring is an acid-stable precursor and prodrug of highly reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% ef
Externí odkaz:
http://hdl.handle.net/10454/7241
Autor:
Pors, Klaus, Loadman, Paul, Shnyder, Steven, Sutherland, Mark, Sheldrake, Helen M., Guino, M., Kiakos, K., Hartley, J.A., Searcey, M., Patterson, Laurence H.
The identification of an agent that is selectively activated by a cytochrome P450 (CYP) has the potential for tissue specific dose intensification as a means of significantly improving its therapeutic value. Towards this goal, we disclose evidence fo
Externí odkaz:
http://hdl.handle.net/10454/6138
Autor:
Garelnabi, EAE, Pletsas, D, Li, L, Kiakos, K, Karodia, N, Hartley, JA, Phillips, Roger, Wheelhouse, RT
The imidazotetrazine ring is an acid-stable precursor and prodrug of highly-reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% efficiency.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::5b92e127b5ccb62fd4cb2f6d36b495bc
https://eprints.hud.ac.uk/id/eprint/23499/3/PhillipsInfo.pdf
https://eprints.hud.ac.uk/id/eprint/23499/3/PhillipsInfo.pdf
Autor:
Abdallah, QMA, Phillips, Roger, Johansson, F, Helleday, D, Cosentino, L, Abdel-Rahman, H, Etzad, J, Wheelhouse, RT, Kiakos, K, Bingham, JP, Hartley, JA, Patterson, LH, Pors, K
Alchemix is an exemplar of a class of anthraquinone with efficacy against multidrug resistant tumors. We have explored further the mechanism of action of alchemix and investigated the effect of extending its side arm bearing the alkylating functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ce537a2c4e95f62c91ea93975371aaa1
https://eprints.hud.ac.uk/id/eprint/23493/1/Abdullah_et_al_2012.pdf
https://eprints.hud.ac.uk/id/eprint/23493/1/Abdullah_et_al_2012.pdf
Autor:
Kiakos, K.
CC-1065 and the duocarmycins are highly potent anticancer agents, exerting their biological activity through covalently reacting with adenine-N3 in the minor groove of AT-rich sequences. The alkylation properties and cytotoxicity of a series of novel
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639522
The design and synthesis of the two cytotoxic derivatives 15 and 16 of the novel pyrrolo[1′,2′:1,2][1,4]diazepin[7,6-b]indol-5(6H)-one nucleus is described. Readily available methyl 2-indolecarboxylates 5 and 6 are nitrosated with NaNO2 in AcOH t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::9e82283d0d19697665826e02ec672985
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3068131
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3068131
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Publikováno v:
In European Journal of Cancer July 2016 61 Supplement 1:S139-S139
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