Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kia Pedersen"'
Autor:
Maurice Michel, Evert J. Homan, Elisée Wiita, Kia Pedersen, Ingrid Almlöf, Anna-Lena Gustavsson, Thomas Lundbäck, Thomas Helleday, Ulrika Warpman Berglund
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Computational chemistry has now been widely accepted as a useful tool for shortening lead times in early drug discovery. When selecting new potential drug targets, it is important to assess the likelihood of finding suitable starting points for lead
Externí odkaz:
https://doaj.org/article/abfd3227d10e4dbfb17b5970d14a429d
Autor:
Thomas Helleday, Elisee Wiita, Thomas Lundbäck, Ulrika Warpman Berglund, Evert Homan, Maurice Michel, Anna-Lena Gustavsson, Ingrid Almlöf, Kia Pedersen
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Computational chemistry has now been widely accepted as a useful tool for shortening lead times in early drug discovery. When selecting new potential drug targets, it is important to assess the likelihood of finding suitable starting points for lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a90e32c163622a218ebc7e2c3149404
https://doi.org/10.26434/chemrxiv.10026929.v1
https://doi.org/10.26434/chemrxiv.10026929.v1
Publikováno v:
Molecular and Cellular Biology. 22:7812-7819
Ligand activation of Notch receptors leads to release of the intracellular receptor domain (Notch IC), which translocates to the nucleus and interacts with the DNA-binding protein RBP-Jkappa to control expression of specific target genes. A number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b774af69d039a15b0be2c49e543c3593
https://doi.org/10.1128/mcb.22.22.7812-7819.2002
https://doi.org/10.1128/mcb.22.22.7812-7819.2002
Publikováno v:
Karolinska Institutet
Notch signal transduction is mediated by proteolysis of the receptor and translocation of the intracellular domain (IC) into the nucleus, where it functions as a regulator of HES gene expression after binding to the DNA-binding protein RBP-J kappa. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6355304e81d62226eb47146e3dfde94b
https://doi.org/10.1016/s0925-4773(01)00373-2
https://doi.org/10.1016/s0925-4773(01)00373-2
Autor:
Johan Lundkvist, Cong Yu, Philip Thomas, Kia Pedersen, Harry Li, Sheu Fen Lee, Gang Yu, W. Christian Wigley, Weiping Han, Myungsil Lim, Sanjiv J. Shah, Yi Heng Hao
Publikováno v:
The Journal of biological chemistry. 279(6)
The multipass membrane protein APH-1, found in the gamma-secretase complex together with presenilin, nicastrin, and PEN-2, is essential for Notch signaling in Caenorhabditis elegans embryos and is required for intramembrane proteolysis of Notch and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdcc453ac22fcd65b0c80e0d7880738
https://pubmed.ncbi.nlm.nih.gov/14627705
https://pubmed.ncbi.nlm.nih.gov/14627705