Výsledky vyhledávání - "Ki Woon Sung"

Akademický článek

Targeted degradation of ⍺-synuclein aggregates in Parkinson’s disease using the AUTOTAC technology

Autor: Jihoon Lee, Ki Woon Sung, Eun-Jin Bae, Dabin Yoon, Dasarang Kim, Jin Saem Lee, Da-ha Park, Daniel Youngjae Park, Su Ran Mun, Soon Chul Kwon, Hye Yeon Kim, Joo-Ok Min, Seung-Jae Lee, Young Ho Suh, Yong Tae Kwon

Publikováno v: Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-21 (2023)

Abstract Background There are currently no disease-modifying therapeutics for Parkinson’s disease (PD). Although extensive efforts were undertaken to develop therapeutic approaches to delay the symptoms of PD, untreated α-synuclein (α-syn) aggreg

Externí odkaz: https://doaj.org/article/63f416f66800494bb59e84f43141648f

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Akademický článek

p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)

Soluble misfolded proteins that fail to be degraded by the ubiquitin proteasome system (UPS) are redirected to autophagy via specific adaptors, such as p62. Here the authors show that p62 recognises N-degrons in these proteins, acting as a N-recognin

Externí odkaz: https://doaj.org/article/a427518b7ba242ffb3606852a4c4bba9

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The Cys-N-degron pathway modulates pexophagy through the N-terminal oxidation and arginylation of ACAD10

Autor: Sang Mi Shim, Ha Rim Choi, Soon Chul Kwon, Hye Yeon Kim, Ki Woon Sung, Eui Jung Jung, Su Ran Mun, Tae Hyun Bae, Dong Hyun Kim, Yeon Sung Son, Chan Hoon Jung, Jihoon Lee, Min Jae Lee, Joo-Won Park, Yong Tae Kwon

In the N-degron pathway, N-recognins recognize cognate substrates for degradation via the ubiquitin (Ub)-proteasome system (UPS) or the autophagy-lysosome system (hereafter autophagy). We have recently shown that the autophagy receptor SQSTM1/p62 (se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3370da7dfe8cc8916350a13cb2c9c6

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Multi-Batch Scheduling for Improving Performance of Hyperledger Fabric Based IoT Applications

Autor: Sangji Bae, Seungjai Min, Sangwon Lee, Chang-Suk Yoon, Hyojung Lee, Ki-Woon Sung, Kyusang Lee, Sangjun Kang

Publikováno v: GLOBECOM

Blockchain technology has been regarded as a paradigm that enables enterprises to deploy decentralized Internet of things (IoT) applications, which require security, mutual truthfulness, privacy, and data reliability. However, the adoption of blockch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f8a4875008d4ceb084e617a2cb65346
https://doi.org/10.1109/globecom38437.2019.9013551

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Economic Analysis of Blockchain Technology on Digital Platform Market

Autor: Seungjai Min, Ki-Woon Sung, Kyusang Lee, Hyojung Lee, Jae-Seok Lee

Publikováno v: PRDC

Blockchain technology on the platform business becomes a new paradigm which gets security, irreversibility, and trustfulness closer to both of clients and service providers (SPs) for providing a better quality of service. To provide an economic analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de7ee67373fed0c27fdaab87999e48e3
https://doi.org/10.1109/prdc.2018.00020

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The endoplasmic reticulum–residing chaperone BiP is short-lived and metabolized through N-terminal arginylation

Autor: Daeho Kim, Yong Tae Kwon, Ha Rim Choi, Aaron Ciechanover, Sang Mi Shim, Joonsung Hwang, Ki Woon Sung, Hyunjoo Cha-Molstad, Bo Yeon Kim, Sung Tae Kim, Su Ran Mun, Yoon Jee Lee

Publikováno v: Science Signaling. 11

BiP and other endoplasmic reticulum (ER)-resident proteins are thought to be metabolically stable and to function primarily in the ER lumen. We sought to assess how the abundance of these proteins dynamically fluctuates in response to various stresse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b46bbf836edf79ef3ecb5f5b3ebce9
https://doi.org/10.1126/scisignal.aan0630

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p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathwaywhich modulates autophagosome biogenesis

Publikováno v: NATURE COMMUNICATIONS(8)
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications

Macroautophagy mediates the selective degradation of proteins and non-proteinaceous cellular constituents. Here, we show that the N-end rule pathway modulates macroautophagy. In this mechanism, the autophagic adapter p62/SQSTM1/Sequestosome-1 is an N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c1df87add4855d6e4ed5c4785cebed
http://open-repository.kisti.re.kr/cube/handle/open_repository/482901.do

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Effects of Regular Exercise and L-Arginine Intake on Abdominal Fat, GH/IGF-1 Axis, and Circulating Inflammatory Markers in the High Fat Diet-Induced Obese Aged Rat

Autor: Jung Suk Kim, Byung Jin Min, Young June Yoo, Sok Park, Young Jun Lee, Kyoung Shil Park, Ki Woon Sung, Jin Lee, Yong Sub Shin, Cheon Ho Lee, Hun Jung

Publikováno v: Journal of Life Science. 22:516-523

The purpose of this study was to investigate the effect of exercise and/or L-arginine on abdominal fat, IGF-1 on GH/IGF-1 axis, fibrinogen, and PAI-1 in aged and obese rats. Male Sprague-Dawley rats were treated with a D-galactose aging inducing agen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f858dcee92f9b0ca85663112332816b1
https://doi.org/10.5352/jls.2012.22.4.516

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