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Akademický článek

An analysis of variants in TARDBP in the Korean population with amyotrophic lateral sclerosis: comparison with previous data

Autor: Wonjae Sung, Jin-Ah Kim, Yong Sung Kim, Jinseok Park, Ki-Wook Oh, Jung-Joon Sung, Chang-Seok Ki, Young-Eun Kim, Seung Hyun Kim

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)

Abstract The TARDBP gene variant is a known major cause of amyotrophic lateral sclerosis (ALS), with limited reports of Korean patients with ALS harboring the variants in TARDBP. This large cohort study introduces four ALS patients who share the p.M3

Externí odkaz: https://doaj.org/article/14f41a8354e64507bdf342829a671cca

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Akademický článek

Long-term survival benefits of intrathecal autologous bone marrow-derived mesenchymal stem cells (Neuronata-R®: lenzumestrocel) treatment in ALS: Propensity-score-matched control, surveillance study

Autor: Jae-Yong Nam, Sehwan Chun, Tae Yong Lee, Yunjeong Seo, Kwijoo Kim, Jinseok Park, Wonjae Sung, Ki-Wook Oh, Sanggon Lee, Jin-Sung Park, Juyeon Oh, Kyung Cheon Chung, Hyonggin An, Hyeon Sik Chu, Bugyeong Son, Seung Hyun Kim

Publikováno v: Frontiers in Aging Neuroscience, Vol 15 (2023)

ObjectiveNeuronata-R® (lenzumestrocel) is an autologous bone marrow-derived mesenchymal stem cell (BM-MSC) product, which was conditionally approved by the Korean Ministry of Food and Drug Safety (KMFDS, Republic of Korea) in 2013 for the treatment

Externí odkaz: https://doaj.org/article/6daa73d3c6f74fa48481ba308fa765c9

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Akademický článek

Efficacy and safety of Lenzumestrocel (Neuronata-R® inj.) in patients with amyotrophic lateral sclerosis (ALSUMMIT study): study protocol for a multicentre, randomized, double-blind, parallel-group, sham procedure-controlled, phase III trial

Autor: Jae-Yong Nam, Tae Yong Lee, Kwijoo Kim, Sehwan Chun, Min Sung Kim, Jin-Hong Shin, Jung-Joon Sung, Byoung Joon Kim, Byung-Jo Kim, Ki-Wook Oh, Kyung Suk Kim, Seung Hyun Kim

Publikováno v: Trials, Vol 23, Iss 1, Pp 1-15 (2022)

Abstract Background A single cycle (two repeated treatments) with intrathecal autologous bone marrow-derived mesenchymal stem cells (BM-MSCs, 26-day interval) showed safety and provided therapeutic benefit lasting 6 months in patients with ALS but di

Externí odkaz: https://doaj.org/article/32d0808cc0c04903a7ee541739ee974f

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Role of NCKAP1 in the Defective Phagocytic Function of Microglia-Like Cells Derived from Rapidly Progressing Sporadic ALS

Autor: Min-Young Noh, Min-Soo Kwon, Ki-Wook Oh, Minyeop Nahm, Jinseok Park, Young-Eun Kim, Chang-Seok Ki, Hee Kyung Jin, Jae-sung Bae, Seung Hyun Kim

Publikováno v: Molecular Neurobiology.

Microglia plays a key role in determining the progression of amyotrophic lateral sclerosis (ALS), yet their precise role in ALS has not been identified in humans. This study aimed to identify a key factor related to the functional characteristics of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c15fc1d3a6213950aa9d27a2e9dba634
https://doi.org/10.1007/s12035-023-03339-2

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Characteristics of Dysphagia Based on the Type of ALS in Korean Patients Evaluated Using Videofluoroscopic Study: A Retrospective Analysis

Autor: Yu Chan Park, Jae Young Lee, Jung Soo Lee, Jin Seok Park, Ki Wook Oh, Seung Hyun Kim, Mi Jung Kim

Publikováno v: Dysphagia. 37:1748-1756

Dysphagia is one of the main serious issues for amyotrophic lateral sclerosis (ALS) patients because of causing malnutrition and aspiration pneumonia. Early detection and management of dysphagia are essential for the long-term survival. In this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9cd2da328daf8790e148a5f41df80b
https://doi.org/10.1007/s00455-022-10430-8

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