Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ki Dong Koo"'
Autor:
Ki Dong Koo, Sang Won Seo, Jae-Ung Choi, Bettina Platt, Dongchul Lim, Deog-Young Choi, Hyo-Shin Kwak, Heuisul Park, Kyeongsik Min
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2900-2904
We describe synthesis and evaluation of a series of cyclic urea derivatives with hydroxylethylamine isostere. Modification of P3, P1, and P2′ and combination of SAR display a >100-fold increase in potency with good cellular activity (IC50 = 0.15 μ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf61e1fe152d19a37acc6b6aeac64aac
https://doi.org/10.1016/j.bmcl.2008.03.081
https://doi.org/10.1016/j.bmcl.2008.03.081
Autor:
Chang Seok Lee, Geun Tae Kim, Min-Jung Kim, Sang Yong Hong, Hee Oon Han, Gwong-Cheung Hur, O Hwan Kwon, Kyoung-Hee Kim, Sungsub Kim, Jong Sung Koh, Ki Dong Koo, Hyeon Joo Yim, Tae Sik Kwon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4167-4172
Synthesis of a novel series of DPPIV inhibitors with 1,2,4- and 1,3,4-oxadiazolyl ketone derivatives and its structure–activity relationships are discussed. Compound 18h showed good inhibitory activity against DPPIV and favorable pharmacokinetic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9292fe70f399944b3adad2316c5fd0
https://doi.org/10.1016/j.bmcl.2007.05.046
https://doi.org/10.1016/j.bmcl.2007.05.046
Publikováno v:
ChemInform. 32
The synthesis and biological activities of a series of new 1β-methylcarbapenems 1a–h having heteroaromatic thioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1,2,3-thiadiazole derivative 1h showed the most poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b42746b61f7f7e0f489e57445aaf157f
https://doi.org/10.1002/chin.200152207
https://doi.org/10.1002/chin.200152207
Autor:
Hee-Kyung Chung, Kyoung-Hee Kim, Seung H. Kim, Hee Oon Han, Jong Sung Koh, Sung Ho Woo, Hyeon Joo Yim, Chang Seok Lee, Ki Dong Koo, Geun Tae Kim, Gwong-Cheung Hur
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(4)
Oxime ethers of alpha-acyl-beta-phenylpropanoic acids were prepared to apply as PPARalpha and gamma dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC(50) of 19 and 13nM in PPARalpha and gamma, respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff6d1356a62dd8372bcc98a6796a737
https://pubmed.ncbi.nlm.nih.gov/17157019
https://pubmed.ncbi.nlm.nih.gov/17157019
Autor:
Ki Dong Koo, Hasik Youn, Geun Tae Kim, Hyung Yeul Joo, Eun-Jung Ryu, Yang Rae Cho, Chang Seok Lee, Yong-Jin Jang
Publikováno v:
ChemInform. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4fa64bc09df10a2892874162af6eb7
https://doi.org/10.1002/chin.200502222
https://doi.org/10.1002/chin.200502222
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(17)
The synthesis and biological activities of a series of new 1β-methylcarbapenems 1a–h having heteroaromatic thioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1,2,3-thiadiazole derivative 1h showed the most poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c7b47f525eab7d164d7f325b797898
https://pubmed.ncbi.nlm.nih.gov/11527740
https://pubmed.ncbi.nlm.nih.gov/11527740
Publikováno v:
ChemInform. 31
The synthesis and biological activities of a series of new 1β-methylcarbapenems 1a–l having tetrazolothioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1c showed the most potent antibacterial activity and advanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cc2008221debaf3d39aaf0736ec3762
https://doi.org/10.1002/chin.200042213
https://doi.org/10.1002/chin.200042213
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(13)
The synthesis and biological activities of a series of new 1β-methylcarbapenems 1a–l having tetrazolothioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1c showed the most potent antibacterial activity and advanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41acb9fca3b157218015e880453e3e69
https://pubmed.ncbi.nlm.nih.gov/10888323
https://pubmed.ncbi.nlm.nih.gov/10888323