Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Khvat A"'
Autor:
Ivachtchenko, Alexandre V.1 (AUTHOR) av@chemdiv.com, Khvat, Alexander V.1 (AUTHOR), Shkil, Dmitrii O.1 (AUTHOR)
Publikováno v:
International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9199. 40p.
Autor:
Yaremenko, Fedor, Beryozkina, Tetyana, Khvat, Alexander, Svidlo, Irina, Shishkin, Oleg, Shishkina, Svetlana, Orlov, Valeriy
Publikováno v:
In Journal of Molecular Structure 2008 874(1):57-63
Autor:
Martin F Strand, Steven R Wilson, Jennifer L Dembinski, Daniel D Holsworth, Alexander Khvat, Ilya Okun, Dirk Petersen, Stefan Krauss
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e19904 (2011)
Hedgehog (Hh) signaling is over-activated in several solid tumors where it plays a central role in cell growth, stroma recruitment and tumor progression. In the Hh signaling pathway, the Smoothened (SMO) receptor comprises a primary drug target with
Externí odkaz:
https://doaj.org/article/881d0f9f884f4c36b8cea2f62c44edd2
Autor:
Okun, Ilya *, Malarchuk, Sergei, Dubrovskaya, Elena, Khvat, Alexander, Tkachenko, Sergey, Kysil, Volodymyr, Kravchenko, Dmitry, Ivachtchenko, Alexandre
Publikováno v:
In SLAS Discovery September 2006 11(6):694-703
Autor:
Okun, Ilya *, Malarchuk, Sergei, Dubrovskaya, Elena, Khvat, Alexander, Tkachenko, Sergey, Kysil, Volodymyr, Ilyin, Alexey, Kravchenko, Dmitry, Prossnitz, Eric R., Sklar, Larry, Ivachtchenko, Alexandre
Publikováno v:
In SLAS Discovery April 2006 11(3):277-285
Publikováno v:
Педиатрическая фармакология, Vol 9, Iss 1, Pp 125-126 (2012)
Externí odkaz:
https://doaj.org/article/29b30129a2024b02985561109d5f35bc
Autor:
Arturo Galvani, Daniele Donati, Emiliana Corti, Alessandra Cirla, Paolo Orsini, Elena Casale, Francesco Sola, Mikhail Krasavin, Marina Fasolini, Enrico Pesenti, Barbara Forte, Rita Perego, Antonella Isacchi, Alina Busel, Daniela Borghi, Alessia Montagnoli, Fabio Zuccotto, Federico Riccardi-Sirtori, Eduard R. Felder, Helena Posteri, Rosita Lupi, Alexander Viktorovich Khvat, Marina Ciomei, Daniele Pezzetta, Gianluca Papeo, Matteo D'anello, Sonia Rainoldi, Francesco Caprera, Alessandra Scolaro
Publikováno v:
Journal of Medicinal Chemistry. 58:6875-6898
The nuclear protein poly(ADP-ribose) polymerase-1 (PARP-1) has a well-established role in the signaling and repair of DNA and is a prominent target in oncology, as testified by the number of candidates in clinical testing that unselectively target bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155b01fe1feb286b71832148160cb556
https://doi.org/10.1021/acs.jmedchem.5b00680
https://doi.org/10.1021/acs.jmedchem.5b00680
Autor:
Denise E. Lackey, Ruth T. Yu, Christopher Liddle, Alexander Viktorovich Khvat, Sungsoon Fang, Sandra Jacinto, David A. Brenner, Alan R. Saltiel, Jae Myoung Suh, Kristina Schoonjans, Alessia Perino, Elizabeth Yu, Yelizaveta Lukasheva, Bernd Schnabl, Sally Coulter, Ronald M. Evans, Michael Downes, Annette R. Atkins, Olivia Osborn, Jerrold M. Olefsky, Shannon M. Reilly, Eiji Yoshihara
Publikováno v:
Nature medicine
Nature medicine, vol 21, iss 2
Nature medicine, vol 21, iss 2
The systemic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to promising new therapies targeting cholesterol metabolism, triglyceride production, hepatic steatosis and biliary cholestasis. In contrast to systemic therapy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8594f0afa07a52e99e16c0fb39d38e0a
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320010/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320010/
Autor:
Sergey E. Tkachenko, Alexandre V. Khvat, Alexandre V. Ivachtchenko, Eugene B. Frolov, Oleg D. Mitkin
Publikováno v:
Letters in Drug Design & Discovery. 7:446-451
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad07fc44e23907533687a991cd887f1b
https://doi.org/10.2174/157018010791306579
https://doi.org/10.2174/157018010791306579
Autor:
Alexandre V. Ivachtchenko, Oleg Dmitrievich Mitkin, S. E. Tkachenko, Eugene B. Frolov, Alexandre V. Khvat
Publikováno v:
Chemistry of Heterocyclic Compounds. 46:170-178
A schemes have been proposed for the synthesis of novel 4-substituted 2,7-dimethyl-3,4-dihydro-1H- and previously unknown 2,7-dimethyl-cis-1,2,3,3a,4,8b-hexahydropyrrolo[3,4-b]indoles. In the case of the Dimebon structural analog 2,7-dimethyl-4-[2-(6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4912178ac58e997cc03a13e75cb0df76
https://doi.org/10.1007/s10593-010-0488-z
https://doi.org/10.1007/s10593-010-0488-z