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Safety, effectiveness and immunogenicity of heterologous mRNA-1273 boost after prime with Ad26.COV2.S among healthcare workers in South Africa: The single-arm, open-label, phase 3 SHERPA study.

Autor: Garrett N; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Discipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa., Reddy T; Biostatistics Research Unit, South African Medical Research Council (SAMRC), Durban, South Africa., Yende-Zuma N; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Biostatistics Research Unit, South African Medical Research Council (SAMRC), Durban, South Africa., Takalani A; Hutchinson Center Research Institute of South Africa, Cape Town, South Africa., Woeber K; Grants, Innovation and Product Development Unit, SAMRC, Durban, South Africa., Bodenstein A; Right to Care, Johannesburg, Gauteng, South Africa., Jonas P; Right to Care, Johannesburg, Gauteng, South Africa., Engelbrecht I; Right to Care, Johannesburg, Gauteng, South Africa., Jassat W; Division of Public Health Surveillance and Response, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Services (NHLS), Johannesburg, Gauteng, South Africa., Moultrie H; Division of Public Health Surveillance and Response, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Services (NHLS), Johannesburg, Gauteng, South Africa., Bradshaw D; Burden of Disease Research Unit, SAMRC, Tygerberg, South Africa., Seocharan I; Biostatistics Research Unit, South African Medical Research Council (SAMRC), Durban, South Africa., Odhiambo J; Hutchinson Center Research Institute of South Africa, Cape Town, South Africa., Khuto K; Hutchinson Center Research Institute of South Africa, Cape Town, South Africa., Richardson SI; SAMRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.; Centre for HIV and STIs, NICD of the NHLS, Johannesburg, Gauteng, South Africa., Omondi MA; Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Nesamari R; Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Keeton RS; Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa., Riou C; Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa., Moyo-Gwete T; SAMRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.; Centre for HIV and STIs, NICD of the NHLS, Johannesburg, Gauteng, South Africa., Innes C; Aurum Institute, Johannesburg, Gauteng, South Africa., Zwane Z; Aurum Institute, Johannesburg, Gauteng, South Africa., Mngadi K; Aurum Institute, Johannesburg, Gauteng, South Africa., Brumskine W; Aurum Institute, Johannesburg, Gauteng, South Africa., Naicker N; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa., Potloane D; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa., Badal-Faesen S; Clinical HIV Research Unit, Johannesburg, Gauteng, South Africa., Innes S; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa., Barnabas S; Family Centre for Research with Ubuntu, Tygerberg, South Africa., Lombaard J; Josha Research, Bloemfontein, South Africa., Gill K; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa., Nchabeleng M; Medunsa Clinical Research Unit, Sefako Makgatho Health Sciences University, Pretoria, South Africa., Snyman E; TASK Eden, George, South Africa., Petrick F; Mzansi Ethical Research Centre, Middelburg, South Africa., Spooner E; SAMRC Clinical Research Site, Durban South Africa., Naidoo L; SAMRC Clinical Research Site, Durban South Africa., Kalonji D; SAMRC Clinical Research Site, Durban South Africa., Naicker V; SAMRC Clinical Research Site, Durban South Africa., Singh N; SAMRC Clinical Research Site, Durban South Africa., Maboa R; Ndlovu Research Centre, Elandsdoorn, South Africa., Mda P; Nelson Mandela Academic Research Unit CRS, Mthatha, South Africa., Malan D; PHOENIX Pharma, Port Elizabeth, South Africa., Nana A; Perinatal HIV Research Unit, Johannesburg, Gauteng, South Africa., Malahleha M; Synergy Biomed Research Institute, East London, South Africa., Kotze P; Qhakaza Mbokodo Research Clinic, Ladysmith, South Africa., Allagappen JJ; Setshaba Research Centre, Soshanguve, South Africa., Diacon AH; TASK Central, Cape Town, South Africa., Kruger GM; Ubuntu Clinical Research, Krugersdorp, Gauteng, South Africa., Patel F; Wits RHI Research Institute, University of Witwatersrand, Johannesburg, Gauteng, South Africa., Moore PL; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; SAMRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.; Centre for HIV and STIs, NICD of the NHLS, Johannesburg, Gauteng, South Africa., Burgers WA; Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, Department of Pathology, University of Cape Town, Cape Town, South Africa.; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa., Anteyi K; Moderna Inc., Cambridge, Massachusetts, United States of America., Leav B; Moderna Inc., Cambridge, Massachusetts, United States of America., Bekker LG; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa., Gray GE; Office of the President and CEO, SAMRC, Cape Town, South Africa., Goga A; Department of Paediatrics and Child Health, University of Pretoria, Pretoria, South Africa.; HIV and other Infectious Diseases Research Unit, SAMRC, Durban, South Africa.

Publikováno v: PLOS global public health [PLOS Glob Public Health] 2024 Dec 05; Vol. 4 (12), pp. e0003260. Date of Electronic Publication: 2024 Dec 05 (Print Publication: 2024).