Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Khuloud Jaqaman"'
Autor:
Michael G. Sugiyama, Aidan I. Brown, Jesus Vega-Lugo, Jazlyn P. Borges, Andrew M. Scott, Khuloud Jaqaman, Gregory D. Fairn, Costin N. Antonescu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology. EGFR is activated by ligand binding, triggering receptor dimerization, activation of kinase activity, and intracellular signaling. EGFR is transiently con
Externí odkaz:
https://doaj.org/article/a76bca4ec1bb40f1bbe42379e8c8888d
Autor:
Jonathon A Ditlev, Anthony R Vega, Darius Vasco Köster, Xiaolei Su, Tomomi Tani, Ashley M Lakoduk, Ronald D Vale, Satyajit Mayor, Khuloud Jaqaman, Michael K Rosen
Publikováno v:
eLife, Vol 8 (2019)
During T cell activation, biomolecular condensates form at the immunological synapse (IS) through multivalency-driven phase separation of LAT, Grb2, Sos1, SLP-76, Nck, and WASP. These condensates move radially at the IS, traversing successive radiall
Externí odkaz:
https://doaj.org/article/4967687a42254a76a7c714088eb669a4
Autor:
Dinah Loerke, Marcel Mettlen, Defne Yarar, Khuloud Jaqaman, Henry Jaqaman, Gaudenz Danuser, Sandra L Schmid
Publikováno v:
PLoS Biology, Vol 7, Iss 3, p e57 (2009)
Total internal reflection fluorescence microscopy (TIR-FM) has become a powerful tool for studying clathrin-mediated endocytosis. However, due to difficulties in tracking and quantifying their heterogeneous dynamic behavior, detailed analyses have be
Externí odkaz:
https://doaj.org/article/dee82b88b47643418049e9a69a4fab8c
Publikováno v:
Nature Machine Intelligence. 5:483-484
Autor:
Michael D. Holsey, Grant T. Gilmore, Adam W. Smith, Jonathan A. Javitch, Avik Kumar Pati, Kaleeckal G. Harikumar, Zhou Zhou, Jozsef Meszaros, Laurence J. Miller, Khuloud Jaqaman, Peter Geggier, Signe Mathiasen, Wesley B. Asher, Megan J. Kaliszewski, Mitchell D. McCauley, Scott C. Blanchard, Daniel S. Terry, Alekhya Govindaraju
Publikováno v:
Nature Methods. 18:397-405
Class C G protein-coupled receptors (GPCRs) are known to form stable homodimers or heterodimers critical for function, but the oligomeric status of class A and B receptors, which constitute >90% of all GPCRs, remains hotly debated. Single-molecule fl
Publikováno v:
Journal of Cell Biology. 221
Colocalization analysis of multicolor microscopy images is a cornerstone approach in cell biology. It provides information on the localization of molecules within subcellular compartments and allows the interrogation of known molecular interactions i
Autor:
Michael G. Sugiyama, Aidan I. Brown, Jesus Vega-Lugo, Andrew M. Scott, Khuloud Jaqaman, Gregory D. Fairn, Costin N. Antonescu
The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology. EGFR is activated by ligand binding, triggering receptor dimerization, activation of kinase activity, and intracellular signaling. EGFR is transiently confined wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8a4c28baec0cf507dbb66aed378eb83
https://doi.org/10.1101/2022.03.04.483015
https://doi.org/10.1101/2022.03.04.483015
Publikováno v:
Bioinformatics
Motivation Microscopy images of cytoskeletal, nucleoskeletal and other structures contain complex junctions of overlapping filaments with arbitrary geometry. Yet, state-of-the-art algorithms generally perform single orientation analysis to segment th
FISIK: Framework for the Inference of In Situ Interaction Kinetics from Single-Molecule Imaging Data
Publikováno v:
Biophys J
Recent experimental and computational developments have been pushing the limits of live-cell single-molecule imaging, enabling the monitoring of intermolecular interactions in their native environment with high spatiotemporal resolution. However, int
Colocalization analysis of multicolor microscopy images is a cornerstone approach in cell biology. It provides information on the localization of molecules within various subcellular compartments and allows the interrogation of molecular interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be9c3f7b616ef3df5ed6952e2588da9e
https://doi.org/10.1101/2021.06.16.448703
https://doi.org/10.1101/2021.06.16.448703