Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Khrystyna Uhlitskykh"'
Autor:
John S. Bomalaski, Yee Chao, Ghassan K. Abou-Alfa, Wint Swe, Khrystyna Uhlitskykh, Richard K. G. Do, Imane El Dika, Xiaoxing Feng, Amanda Johnston, James J. Harding, Eileen M. O'Reilly, Tsang-En Wang, C. L. Ho, Brittanie M Millang, Yen-Yang Chen, Chia Jui Yen, Shukui Qin, Chien-Feng Li, Tsai-Sheng Yang
Publikováno v:
Journal of Clinical Oncology. 37:TPS477-TPS477
TPS477 Background: Arginine depletion interferes with pyrimidine metabolism as well as DNA damage repair pathways, and preclinical data indicate that pairing pegylated arginine deiminase (ADI-PEG 20) with fluoropyrimidines or platinum enhances cytoto
Autor:
Khrystyna Uhlitskykh, James J. Harding, Ghassan K. Abou-Alfa, Xiaoxing Feng, Eileen M. O'Reilly, Jessica Frick, John S. Bomalaski, Richard K. G. Do, Ellen Hollywood, Casey R. Hamilton, Emily Valentino, Peter Justin Wan, Chien-Feng Li, Amanda Johnston
Publikováno v:
Journal of Clinical Oncology. 36:4085-4085
4085Background: Arginine depletion interferes with pyrimidine metabolism as well as DNA damage repair pathways, and preclinical data indicate that pairing pegylated arginine deaminase (ADI-PEG 20) ...
Autor:
Khrystyna Uhlitskykh, Adalberto Barba, Peter Justin Wan, Kay Chia-Wei Liu, James J. Harding, John S. Bomalaski, Eileen M. O'Reilly, Maeve A. Lowery, Leonard B. Saltz, Ghassan K. Abou-Alfa, Amanda Johnston, Casey R. Hamilton
Publikováno v:
Journal of Clinical Oncology. 35:384-384
384 Background: ADI-PEG-20 (pegylated arginine deiminase), an arginine degrading enzyme, and FOLFOX each exhibit clinical activity in a HCC pt subset. Preclinical data indicate that arginine depletion interferes with folate and pyrimidine metabolism