Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Khosrow Kashfi"'
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 23, Pp 937-959 (2024)
Type 2 diabetes (T2D) significantly increases the risk of vascular complications (12-32 %), which are a major cause of death (over 50 %) in T2D patients. In T2D, both endothelial (ET) and vascular smooth muscle (VSM) cells are impaired, which act as
Externí odkaz:
https://doaj.org/article/c15477e0d35f4ab68a30509b75090841
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 23, Pp 18-33 (2024)
Ischemic heart disease (IHD) is the leading cause of mortality worldwide and can be complicated by myocardial infarction (MI), leading to cardiac failure. Inorganic nitrite and nitrate, which release nitric oxide (NO), can protect the heart against m
Externí odkaz:
https://doaj.org/article/e556c7054cb4498782b53396a0aad747
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Hydrogen sulfide (H2S) has many physiological and pathological roles in the human body. Sodium hydrosulfide (NaHS) is widely used as a pharmacological tool for assessing H2S effects in biological experiments. Although H2S loss from NaHS solu
Externí odkaz:
https://doaj.org/article/78e9e8feaaff474c87ca93512e4250d9
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Menopause is associated with reduced nitric oxide (NO) bioavailability and lower tolerance against myocardial ischemia-reperfusion (IR) injury. This study investigated whether long-term nitrate administration provides resistance against
Externí odkaz:
https://doaj.org/article/0e39aa51a0b14a109c0d2390b4a0261c
Publikováno v:
BMC Cardiovascular Disorders, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background The favorable effects of nitrate against myocardial ischemia-reperfusion injury (MIRI) have primarily focused on male rats and in short term. Here we determine the impact of long-term nitrate intervention on baseline cardiac funct
Externí odkaz:
https://doaj.org/article/4655595db2f640cf95d4c08533a47077
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-14 (2023)
Abstract Vascular nitric oxide (NO•) resistance, manifested by an impaired vasodilator function of NO• in both the macro- and microvessels, is a common state in type 2 diabetes (T2D) associated with developing cardiovascular events and death. Her
Externí odkaz:
https://doaj.org/article/10923a5ca5ec423780b771ba5f9ba892
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Protein-based nanocarriers have demonstrated good potential for cancer drug delivery. Silk sericin nano-particle is arguably one of the best in this field. In this study, we developed a surface charge reversal sericin-based nanocarrier to co
Externí odkaz:
https://doaj.org/article/9253160401e3435283d6e514b6fd3aab
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 26, Iss 4, Pp 420-428 (2023)
Objective(s): Nitrite, a nitric oxide (NO) donor, increases insulin secretion from pancreatic islets and has positive metabolic effects in type 2 diabetes (T2D). Here, we test the hypothesis of whether nitrite-induced insulin secretion is due to blun
Externí odkaz:
https://doaj.org/article/b86317804b4543628678c0da8a3117fe
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Nitrate therapy has been suggested to boost nitric oxide (NO) levels in type 2 diabetes (T2D); however, little is known about nitrate transport across the membranes. This study aimed to assess changes in the mRNA expression of sialin, as a n
Externí odkaz:
https://doaj.org/article/876c4d8731674bca9da51894476635b8
Long-term inorganic nitrate administration protects against ovariectomy-induced osteoporosis in rats
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 21, Pp 1151-1166 (2022)
The risk of osteoporotic fractures increases in women after menopause. This study aims at determining the effects of long-term inorganic nitrate administration against ovariectomy-induced osteoporosis in rats. Rats were divided into 4 groups (n=6/gro
Externí odkaz:
https://doaj.org/article/a2230e85a70d45d991fe14382ed7a93e