Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance.

Autor: Mavor D; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Barlow KA; Bioinformatics Graduate Group, University of California, San Francisco 94158, USA., Asarnow D; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Birman Y; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Britain D; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Chen W; Bioinformatics Graduate Group, University of California, San Francisco 94158, USA., Green EM; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Kenner LR; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Mensa B; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Morinishi LS; Bioinformatics Graduate Group, University of California, San Francisco 94158, USA., Nelson CA; Bioinformatics Graduate Group, University of California, San Francisco 94158, USA., Poss EM; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Suresh P; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Tian R; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Arhar T; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Ary BE; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Bauer DP; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Bergman ID; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Brunetti RM; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Chio CM; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Dai SA; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Dickinson MS; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Elledge SK; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Helsell CVM; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Hendel NL; Bioinformatics Graduate Group, University of California, San Francisco 94158, USA., Kang E; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Kern N; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Khoroshkin MS; Bioinformatics Graduate Group, University of California, San Francisco 94158, USA., Kirkemo LL; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Lewis GR; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Lou K; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Marin WM; Bioinformatics Graduate Group, University of California, San Francisco 94158, USA., Maxwell AM; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., McTigue PF; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Myers-Turnbull D; Bioinformatics Graduate Group, University of California, San Francisco 94158, USA., Nagy TL; Bioinformatics Graduate Group, University of California, San Francisco 94158, USA., Natale AM; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Oltion K; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Pourmal S; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Reder GK; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Rettko NJ; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Rohweder PJ; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Schwarz DMC; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Tan SK; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Thomas PV; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Tibble RW; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Town JP; Bioinformatics Graduate Group, University of California, San Francisco 94158, USA., Tsai MK; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Ugur FS; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Wassarman DR; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Wolff AM; Biophysics Graduate Group, University of California, San Francisco 94158, USA., Wu TS; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco 94158, USA., Bogdanoff D; Department of Biochemistry and Biophysics, University of California, San Francisco 94158, USA., Li J; Department of Chemistry Undergraduate Program, University of California, Davis 95616, USA., Thorn KS; Department of Biochemistry and Biophysics, University of California, San Francisco 94158, USA., O'Conchúir S; Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biology (QBI), San Francisco 94158, USA., Swaney DL; Department of Cellular and Molecular Pharmacology, California Institute for Quantitative Biology (QBI), San Francisco 94158, USA., Chow ED; Department of Biochemistry and Biophysics, University of California, San Francisco 94158, USA., Madhani HD; Department of Biochemistry and Biophysics, University of California, San Francisco 94158, USA., Redding S; Department of Biochemistry and Biophysics, University of California, San Francisco 94158, USA., Bolon DN; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester 01655, USA., Kortemme T; Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biology (QBI), San Francisco 94158, USA., DeRisi JL; Department of Biochemistry and Biophysics, University of California, San Francisco 94158, USA., Kampmann M; Department of Biochemistry and Biophysics, University of California, San Francisco 94158, USA martin.kampmann@ucsf.edu jfraser@fraserlab.com.; Institute for Neurodegenerative Diseases, University of California, San Francisco 94158, USA., Fraser JS; Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biology (QBI), San Francisco 94158, USA martin.kampmann@ucsf.edu jfraser@fraserlab.com.

Publikováno v: Biology open [Biol Open] 2018 Jul 23; Vol. 7 (7). Date of Electronic Publication: 2018 Jul 23.

Genetic determinants of in vivo fitness and diet responsiveness in multiple human gut Bacteroides.

Autor: Wu M; Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA. Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63108, USA., McNulty NP; Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA., Rodionov DA; Infectious and Inflammatory Disease Center, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, 92037 CA, USA. A. A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow 127994, Russia., Khoroshkin MS; A. A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow 127994, Russia., Griffin NW; Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA. Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63108, USA., Cheng J; Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA. Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63108, USA., Latreille P; Monsanto Company, St. Louis, MO 63167, USA., Kerstetter RA; Monsanto Company, St. Louis, MO 63167, USA., Terrapon N; Architecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique et Aix-Marseille Université 13288 Marseille cedex 9, France., Henrissat B; Architecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique et Aix-Marseille Université 13288 Marseille cedex 9, France. Department of Biological Sciences, King Abdulaziz University, Jeddah, Saudi Arabia., Osterman AL; Infectious and Inflammatory Disease Center, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, 92037 CA, USA., Gordon JI; Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA. jgordon@wustl.edu.

Publikováno v: Science (New York, N.Y.) [Science] 2015 Oct 02; Vol. 350 (6256), pp. aac5992.