Optimal Dual-Targeted CAR Construct Simultaneously Targeting Bcma and GPRC5D Prevents Bcma-Escape Driven Relapse in Multiple Myeloma

Autor: Yunxin Chen, Renier J. Brentjens, Andrea V. Lopez, Eric L. Smith, Khong Y. Ng, Hans Wendel, Mette Staehr, Terence J. Purdon, Carlos Fernández de Larrea

Publikováno v: De Larrea, C F, Stæhr, M, Lopez, A, Chen, Y, Purdon, T J, Ng, K Y, Wendel, H, Brentjens, R J & Smith, E L 2019, ' Optimal Dual-Targeted CAR Construct Simultaneously Targeting Bcma and GPRC5D Prevents Bcma-Escape Driven Relapse in Multiple Myeloma ', Blood, vol. 134, no. Suppl. 1, 136 . https://doi.org/10.1182/blood-2019-126145

Multiple myeloma (MM) remains generally incurable, calling for the development of novel treatment strategies such as chimeric antigen receptor (CAR) T cell therapy. Most clinically tested CAR T cell therapies for MM target B cell maturation antigen (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8137441d5d84333c45b606f94634545
https://portal.findresearcher.sdu.dk/da/publications/5da5aa07-4772-4beb-b9f9-de787a734cb2

Rosette Assay: Highly Customizable Dot-Blot for SH2 Domain Screening

Autor: Khong Y, Ng, Kazuya, Machida

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1555

With a growing number of high-throughput studies, structural analyses, and availability of protein-protein interaction databases, it is now possible to apply web-based prediction tools to SH2 domain-interactions. However, in silico prediction is not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::47cc8ad4326f3596a25615cb105f4b4e
https://pubmed.ncbi.nlm.nih.gov/28092049

Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity

Autor: Taofei Yin, Kazuya Machida, Khong Y. Ng, Yi I. Wu, Bruce J. Mayer

Publikováno v: Oncogene

The Crk SH2/SH3 adaptor and the Abl nonreceptor tyrosine kinase were first identified as oncoproteins, and both can induce tumorigenesis when overexpressed or mutationally activated. We previously reported the surprising finding that inhibition or kn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1380949a2904355ac8db9ca4a9731538
https://doi.org/10.1038/onc.2014.210

Enterovirus 71 encephalomyelitis and Japanese encephalitis can be distinguished by topographic distribution of inflammation and specific intraneuronal detection of viral antigen and RNA

Autor: Kwai-Peng Chan, W.F Ng, Kum Thong Wong, G. Lau, Hiroyuki Shimizu, Vydianathan Ravi, Bishan Dass Radotra, I.J. Su, P. Macorelles, Kien Chai Ong, Mary Jane Cardosa, Khong Y. Ng, A Mahadevan, S K Shankar, Noriyo Nagata, Anita Desai, S. Vallet, A.E. Ling, T. Takasaki

Publikováno v: Neuropathology and Applied Neurobiology. 38:443-453

Aims: To investigate if two important epidemic viral encephalitis in children, Enterovirus 71 (EV71)e ncephalomyelitis and Japanese encephalitis (JE) whose clinical and pathological features may be nonspecific and overlapping, could be distinguished.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4520cda3c2f7fbc3c3f10cd31f574e0c
https://doi.org/10.1111/j.1365-2990.2011.01247.x

Proteins that bind the Src homology 3 domain of CrkI have distinct roles in Crk transformation

Autor: Kazuya Machida, Ji Zheng, Khong Y. Ng, Kevin P. Claffey, Susumu Antoku, Bruce J. Mayer

Publikováno v: Oncogene

The v-Crk oncogene product consists of two protein interaction modules, a Src homology 2 (SH2) domain and a Src homology 3 (SH3) domain. Overexpression of CrkI, the cellular homolog of v-Crk, transforms mouse fibroblasts, and elevated CrkI expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d7408c619ae826a96eeab8d4b50a99
https://pubmed.ncbi.nlm.nih.gov/20729917