High-Throughput Luminescent Reporter of Insulin Secretion for Discovering Regulators of Pancreatic Beta-Cell Function

Autor: Burns, Sean M., Vetere, Amedeo, Walpita, Deepika, Dančík, Vlado, Khodier, Carol, Perez, Jose, Clemons, Paul A., Wagner, Bridget K., Altshuler, David

Publikováno v: In Cell Metabolism 6 January 2015 21(1):126-137

Phenotypic Screening for Small Molecules that Protect β‑Cells from Glucolipotoxicity.

Autor: Small, Jonnell C., Joblin-Mills, Aidan, Carbone, Kaycee, Kost-Alimova, Maria, Ayukawa, Kumiko, Khodier, Carol, Dancik, Vlado, Clemons, Paul A., Munkacsi, Andrew B., Wagner, Bridget K.

Publikováno v: ACS Chemical Biology; 5/20/2022, Vol. 17 Issue 5, p1131-1142, 12p

Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction

Autor: Hu, Longqin, Magesh, Sadagopan, Chen, Lin, Wang, Lili, Lewis, Timothy A., Chen, Yu, Khodier, Carol, Inoyama, Daigo, Beamer, Lesa J., Emge, Thomas J., Shen, Jian, Kerrigan, John E., Kong, Ah-Ng Tony, Dandapani, Sivaraman, Palmer, Michelle, Schreiber, Stuart L., Munoz, Benito

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 15 May 2013 23(10):3039-3043

Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform.

Autor: Jiang W; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Shaw S; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Rush J; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Dumont N; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Kim J; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Singh R; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Skepner A; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Khodier C; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Raffier C; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Yan N; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for Cancer Research and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA., Schluter C; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for Cancer Research and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA., Yu X; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Szuchnicki M; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Sathappa M; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Kahn J; Department of Medicine, Brigham and Women's Hospital, Boston, MA., Sperling AS; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., McKinney DC; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Gould AE; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Garvie CW; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Miller PG; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.; Center for Cancer Research and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 21. Date of Electronic Publication: 2024 May 21.