Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Khoa N. Pham"'
Autor:
Khoa N. Pham, Francisco Fernandez-Lima
Publikováno v:
ACS Omega, Vol 6, Iss 44, Pp 29567-29576 (2021)
Externí odkaz:
https://doaj.org/article/c44c96c56d434e748817f64183d2f817
Autor:
Ariel Lewis-Ballester, Khoa N. Pham, Dipanwita Batabyal, Shay Karkashon, Jeffrey B. Bonanno, Thomas L. Poulos, Syun-Ru Yeh
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an immunotherapeutic target for cancer therapy. Here, the authors present the substrate-, inhibitor- and effector-bound hIDO1 crystal structures, which give insights into the mechanism and reveal a secon
Externí odkaz:
https://doaj.org/article/f8b733a4df2546f48fc72aa65deeac3d
Autor:
Francisco Fernandez-Lima, Khoa N. Pham
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 44, Pp 29567-29576 (2021)
ACS Omega, Vol 6, Iss 44, Pp 29567-29576 (2021)
Extracellular histone H4 is an attractive drug target owing to its roles in organ failure in sepsis and other diseases. To identify inhibitors using in silico methods, information on histone H4 structural dynamics and three-dimensional (3D) structura
Publikováno v:
The Journal of Physical Chemistry B. 127:3756-3756
Publikováno v:
J Am Chem Soc
Human indoleamine 2,3-dioxygenase 1 (hIDO1) and human tryptophan dioxygenase (hTDO) are two important heme proteins that degrade the essential amino acid, L-tryptophan (Trp), along the kynurenine pathway. The two enzymes share a similar active site s
Publikováno v:
J Am Chem Soc
Indoleamine 2,3-dioxygenase 1 (hIDO1) and tryptophan dioxygenase (hTDO) are two of the only three heme-based dioxygenases in humans. They have recently been identified as key cancer immunotherapeutic drug targets. While structures of hIDO1 in complex
Autor:
William P. Malachowski, James B. DuHadaway, Alexander J. Muller, Khoa N. Pham, Ariel Lewis-Ballester, George C. Prendergast, Jenny Wai, Eesha Sheikh, Syun Ru Yeh, Maria Winters, Shorouk O. Badir
Publikováno v:
European Journal of Medicinal Chemistry. 162:455-464
Tryptophan (Trp) catabolizing enzymes play an important and complex role in the development of cancer. Significant evidence implicates them in a range of inflammatory and immunosuppressive activities. Whereas inhibitors of indoleamine 2,3-dioxygenase
Publikováno v:
European journal of oral sciencesREFERENCES. 129(1)
This study investigated the potential of red wine in modulating dental erosion kinetics in the presence or absence of salivary pellicle. Polished human enamel specimens were used in two conditions; presence or absence of acquired enamel pellicle; and
Autor:
Nicole Cortés, Raphael G. Raptis, Khoa N. Pham, Alan J. Rodriguez-Santiago, Jaroslava Miksovska
Publikováno v:
Polyhedron. 150:61-68
New Co(III), Cu(II) and Zn(II) complexes of 4,4′-dihydroxy-2,2′-bipyridine (dhbpyH2) have been structurally characterized by single crystal X-ray diffraction methods and studied by electrochemical and spectroscopic techniques. Both bis- and tris-
Autor:
Mark E. Ridgeway, Melvin A. Park, Francisco Fernandez-Lima, Juan Camilo Molano-Arevalo, Kevin Jeanne Dit Fouque, Khoa N. Pham, Jaroslava Miksovska
Publikováno v:
Analytical Chemistry. 89:8757-8765
Globular proteins, such as cytochrome c (cyt c), display an organized native conformation, maintained by a hydrogen bond interaction network. In the present work, the structural interrogation of kinetically trapped intermediates of cyt c was performe