Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Khilevich A"'
Autor:
Bruce A. Dressman, Charles H. Mitch, Mercedes Carpintero, Susana García-Cerrada, John T. Catlow, Tatiana Natali Vetman, Wesley Seidel, Mark Donald Chappell, Jeffrey M. Schkeryantz, Albert Khilevich, Xushan Wang, Allie Edward Tripp, Jeffrey M. Witkin, Maria-Jesus Blanco, Renhua Li, Stephon C. Smith, José Francisco Soriano, Mario Barberis, Steven Swanson, Xia Li, Carlos Jaramillo, Beverly A. Heinz, Thomas C. Britton, Carl D Overshiner, Keith A. Wafford, Eric George Tromiczak, José Eugenio de Diego, James E. Matt, David W. Bedwell, Steven James Quimby, Adam M. Fivush, Paul L. Ornstein
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5663-5668
Negative modulators of metabotropic glutamate 2 & 3 receptors demonstrate antidepressant-like activity in animal models and hold promise as novel therapeutic agents for the treatment of major depressive disorder. Herein we describe our efforts to pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546651449b4bbed891b5bffae098620b
https://doi.org/10.1016/j.bmcl.2016.10.067
https://doi.org/10.1016/j.bmcl.2016.10.067
Autor:
Blanco, Maria-Jesus, Benesh, Dana R., Knobelsdorf, James A., Khilevich, Albert, Cortez, Guillermo S., Mokube, Fese, Aicher, Thomas D., Groendyke, Todd M., Marmsater, Fredrik P., Tang, Tony P., Johnson, Kirk W., Clemens-Smith, Amy, Muhlhauser, Mark A., Swanson, Steven, Catlow, John, Emkey, Renee, Johnson, Michael P., Schkeryantz, Jeffrey M.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 January 2017 27(2):323-328
Autor:
Dressman, Bruce A., Tromiczak, Eric G., Chappell, Mark D., Tripp, Allie E., Quimby, Steven J., Vetman, Tatiana, Fivush, Adam M., Matt, James, Jaramillo, Carlos, Li, Renhua, Khilevich, Albert, Blanco, Maria-Jesus, Smith, Stephon C., Carpintero, Mercedes, de Diego, José Eugenio, Barberis, Mario, García-Cerrada, Susana, Soriano, José F., Schkeryantz, Jeffrey M., Witkin, Jeffrey M., Wafford, Keith A., Seidel, Wesley, Britton, Thomas, Overshiner, Carl D., Li, Xia, Wang, Xu-Shan, Heinz, Beverly A., Catlow, John T., Swanson, Steven, Bedwell, David, Ornstein, Paul L., Mitch, Charles H.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 December 2016 26(23):5663-5668
Autor:
Xu, Ze-Qi, Hollingshead, Melinda G., Borgel, Suzanne, Elder, Cindy, Khilevich, Albert, Flavin, Michael T.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1999 9(2):133-138
Autor:
Fredrik Pehr Marmsater, Jeffrey M. Schkeryantz, Dana Rae Benesh, Maria-Jesus Blanco, Amy Clemens-Smith, Renee Emkey, Kirk W. Johnson, Michael P. Johnson, Fese Mokube, Groendyke Todd Michael, James Allen Knobelsdorf, Tony Pisal Tang, Mark A. Muhlhauser, Cortez Guillermo S, Thomas Daniel Aicher, Albert Khilevich, Steven Swanson, John T. Catlow
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(2)
Pyridylmethylsulfonamide series were the first reported example of positive allosteric modulators (PAM) of the mGlu2 receptor. The hydroxyacetophenone scaffold is a second series of mGlu2 PAMs we have identified. This series of molecules are potent m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5d8e11f4b6d50d127416a2d5c6aa8c
https://pubmed.ncbi.nlm.nih.gov/27908761
https://pubmed.ncbi.nlm.nih.gov/27908761
Autor:
Hong Yu, Sean P. Hollinshead, Anne B. Need, Akihiko Kato, Daniel Ray Mayhugh, Diseroad Benjamin Alan, Paul L. Ornstein, Jon K. Reel, Patrick Gianpietro Spinazze, Jeff Schkeryantz, David S. Bredt, Oscar de Frutos, Beverly A. Heinz, Kevin Matthew Gardinier, Debra Luffer-Atlas, F. Craig Stevens, Vanessa N. Barth, Warren J. Porter, Timothy Andrew Woods, Douglas Linn Gernert, Gregory A. Stephenson, Jeffrey M. Witkin, Kevin D. Burris, Prashant V. Desai, Patric James Hahn, Scott D. Gleason, Steven Swanson, Chunjin Ding, Albert Khilevich
Publikováno v:
Journal of medicinal chemistry. 59(10)
Transmembrane AMPA receptor regulatory proteins (TARPs) are a family of scaffolding proteins that regulate AMPA receptor trafficking and function. TARP γ-8 is one member of this family and is highly expressed within the hippocampus relative to the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f6a1cbca71f336baac901c8fde85e1
https://pubmed.ncbi.nlm.nih.gov/27067148
https://pubmed.ncbi.nlm.nih.gov/27067148
Autor:
Gregory B. Kharas, Emi Hanawa, Benjamin L. Hill, Katherine T. Flynn, Wilbert-John Alvarez, Brigette A. Baronti, Casandra S. Francis, Alena Greenberg, Patrick J. Johnson, Christopher M. Chapman, Ilan R. Khilevich, Peter Park, Salima Atlas, Mustapha Raihane
Publikováno v:
Journal of Macromolecular Science, Part A. 48:428-432
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8831985adbe15dc46efdc6d7ec56c98b
https://doi.org/10.1080/10601325.2011.572812
https://doi.org/10.1080/10601325.2011.572812
Autor:
Tiffany Duffin, Maureen A. Nickols, Barbara B. Chen, Mary Beth Finn, Mark A. Russell, William F. Westlin, Steven L. Settle, Mark L. Boys, Randall K. Rader, Jon A. Klover, Wang Yaping, Thomas D. Penning, Jeffery L. Keene, V. Wayne Engleman, G. Allen Nickols, Christina N. Steininger, Sandra K. Freeman, Melanie L. Hanneke, Khilevich Albert, Marisa M. Westlin, Kristen E. Shannon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3156-3161
We describe a series of pyrazole and isoxazole analogs as antagonists of the α v β 3 receptor. Compounds showed low to sub-nanomolar potency against α v β 3 , as well as good selectivity against α IIb β 3 . In HT29 cells, most analogs also demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e27cd8fc7dca2f6785f6b7c08e8bda4
https://doi.org/10.1016/j.bmcl.2006.03.045
https://doi.org/10.1016/j.bmcl.2006.03.045
Autor:
Rodger F. Henry, Steven A. Buckner, Michael E. Brune, Tracy L. Carr, Sweta P. Katwala, Masaki Nakane, Thomas R. Miller, Arthur A. Hancock, Jorge D. Brioni, Anthony V. Daza, Michael Meyer, John C Cain, William A. Carroll, Robert J. Altenbach, Albert Khilevich, Lynne M. Ireland, Fan Yang, Mark W. Holladay, Meena V. Patel, Rohde Jeffrey J, William H. Bunnelle, Chae H Kang, Timothy A. Esbenshade, Donna M. Gauvin, Teodozyj Kolasa, James P. Sullivan, Karin R. Tietje, Jane Kuk, Pramila Bhatia, Alyssa B. O'Neill, Searle Xenia B, Ivan Milicic, Erol K. Bayburt
Publikováno v:
Journal of Medicinal Chemistry. 47:3220-3235
Structure-activity studies were performed on the alpha(1A)-adrenoceptor (AR) selective agonist N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide (4). Compounds were evaluated for binding activity at the alpha(1A), alpha(1b)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5013ae295bf243228c84c7a005bf8f58
https://doi.org/10.1021/jm030551a
https://doi.org/10.1021/jm030551a
Autor:
John D. Rizzo, Tracy L. Stup, Michael T. Flavin, Albert Khilevich, Robert W. Buckheit, Lin Lin, David E. Zembower, Ze-Qi Xu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:2179-2184
The three chromanone derivatives, (+)-, (-)-, and (+/-)-12-oxocalanolide A (2), were evaluated for in vitro antiviral activities against HIV and simian immunodeficiency virus (SIV). The compounds were determined to be inhibitors of HIV-1 reverse tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34306688dc302145dc54f2a1d058bdc1
https://doi.org/10.1016/s0960-894x(98)00380-1
https://doi.org/10.1016/s0960-894x(98)00380-1