Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Khiem C. Lam"'
1
Abstract 5188: Interrogating the role of the immune microenvironment in the response of brain metastases to immunotherapy using new preclinical melanoma models
Autor: Amélie Lopès, Jessica Rappaport, Eva Pérez Guijarro, Quanyi Chen, Emily Wu, Isabella Church, April Huang, Jessica Bridge, Sung Chin, Cari Smith, Charli Gruen, Khiem C. Lam, Romina E. Araya, Antonella Sassano, Chi-Ping Day, Glenn Merlino, Romina S. Goldszmid
Publikováno v: Cancer Research. 83:5188-5188
Brain metastases (BrM) remain an intractable, deadly complication for advanced melanoma patients and efficient therapeutic strategies are desperately needed. The tumor microenvironment (TME) plays an important role in response to therapy. However, st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::473556e4dd1dcf33b7a2f05787564c65
https://doi.org/10.1158/1538-7445.am2023-5188
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2
Can gut microbes predict efficacy and toxicity of combined immune checkpoint blockade?
Autor: Khiem C. Lam, Romina S. Goldszmid
Publikováno v: Cancer Cell. 39:1314-1316
A recent report in Nature Medicine pinpoints a role for gut microbiota in response and toxicity to combined immune checkpoint blockade targeting CTLA-4 and PD-1. This emergent study provides insights that can be used to leverage microbiota in the des
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce638515607d9c283324b1b06baca4e3
https://doi.org/10.1016/j.ccell.2021.09.013
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3
Neutrophil dynamics in the tumor microenvironment determines therapy efficacy and is regulated by microbiota
Autor: Romina E Araya, Khiem C Lam, April Huang, Quanyi Chen, Martina Di Modica, Amelie Lopes, Howard Yang, Huaitian Liu, Maxwell P. Lee, Romina S. Goldszmid
Publikováno v: The Journal of Immunology. 208:120.03-120.03
Neutrophils play an important role in cancer progression and both pro- and antitumorigenic functions have been described. However, their role in response to therapy and whether environmental signals modulate their function in the tumor microenvironme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ee4639f23fe59ffc0f748ce3ec95cd8
https://doi.org/10.4049/jimmunol.208.supp.120.03
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4
Tumor-intrinsic factors dictate beneficial effect of microbiota-based therapies
Autor: Khiem C Lam, April Huang, Romina E. Araya, Quanyi Chen, Romina S. Goldszmid
Publikováno v: The Journal of Immunology. 208:120.08-120.08
Gut microbiota impacts antitumor immunity and recent studies have shown that manipulating microbiota via fecal transplant can rescue immune checkpoint blockade (ICB) response in refractory melanoma patients. However, not all patients benefited from t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcb78727f9e4727d289863e555a23487
https://doi.org/10.4049/jimmunol.208.supp.120.08
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6
Effect of temperature and time on the thanatomicrobiome of the cecum, ileum, kidney, and lung of domestic rabbits
Autor: Christiane V. Löhr, Natalia Shulzhenko, Khiem C. Lam, Andrey Morgun, Kelsey E Lawrence
Knowledge of changes in the composition of microbial communities (microbiota) in tissues after death, over time, is critical to correctly interpret results of microbiologic testing from postmortem examinations. Limited information is available about
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8a532088b808d83fafe6fdff261914
https://europepmc.org/articles/PMC6838823/
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7
DS1_JVDI_10.1177_1040638719828412 – Supplemental material for Effect of temperature and time on the thanatomicrobiome of the cecum, ileum, kidney, and lung of domestic rabbits
Autor: Lawrence, Kelsey E., Khiem C. Lam, Morgun, Andrey, Shulzhenko, Natalia, Löhr, Christiane V.
Supplemental material, DS1_JVDI_10.1177_1040638719828412 for Effect of temperature and time on the thanatomicrobiome of the cecum, ileum, kidney, and lung of domestic rabbits by Kelsey E. Lawrence, Khiem C. Lam, Andrey Morgun, Natalia Shulzhenko and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a63ec0c7a00d2f0d9e581b4269a6697
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9
Transkingdom network reveals bacterial players associated with cervical cancer gene expression program
Autor: Jialu Hu, Richard R. Rodrigues, Khiem C. Lam, Heidi Lyng, Aleksandra E. Sikora, Dariia Vyshenska, Eva Katrine Aarnes, Natalia Shulzhenko, Anja Nilsen, Andrey Morgun, Ryszard A. Zielke, Nicholas Samuel Brown
Publikováno v: PeerJ, Vol 6, p e5590 (2018)
PeerJ, vol 6, iss 9
PeerJ
Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause the disease. Chromosomal amplifications have been identified as a source of upregulation for cervical cancer driver genes but can
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3aa9393d4cac98cf61db512edf9b0c7
https://peerj.com/articles/5590.pdf
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10
Interplay between viruses and bacterial microbiota in cancer development
Autor: Khiem C. Lam, Andrey Morgun, Dariia Vyshenska, Natalia Shulzhenko
Publikováno v: Seminars in immunology, vol 32, iss C
During the last few decades we have become accustomed to the idea that viruses can cause tumors. It is much less considered and discussed, however, that most people infected with oncoviruses will never develop cancer. Therefore, the genetic and envir
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c67c28e0bb5a07e92c0a5f07bdefe6
https://pubmed.ncbi.nlm.nih.gov/28602713
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