Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Khetemenee Lam"'
Autor:
Adam R. Root, Wei Cao, Bilian Li, Peter LaPan, Caryl Meade, Jocelyn Sanford, Macy Jin, Cliona O’Sullivan, Emma Cummins, Matthew Lambert, Alfredo D. Sheehan, Weijun Ma, Scott Gatto, Kelvin Kerns, Khetemenee Lam, Aaron M. D’Antona, Lily Zhu, William A. Brady, Susan Benard, Amy King, Tao He, Lisa Racie, Maya Arai, Dianah Barrett, Wayne Stochaj, Edward R. LaVallie, James R. Apgar, Kristine Svenson, Lidia Mosyak, Yinhua Yang, Gurunadh R. Chichili, Liqin Liu, Hua Li, Steve Burke, Syd Johnson, Ralph Alderson, William J. J. Finlay, Laura Lin, Stéphane Olland, William Somers, Ezio Bonvini, Hans-Peter Gerber, Chad May, Paul A. Moore, Lioudmila Tchistiakova, Laird Bloom
Publikováno v:
Antibodies, Vol 5, Iss 1, p 6 (2016)
Bispecific antibodies offer a promising approach for the treatment of cancer but can be challenging to engineer and manufacture. Here we report the development of PF-06671008, an extended-half-life dual-affinity re-targeting (DART®) bispecific molec
Externí odkaz:
https://doaj.org/article/8c0c6589f19a4745bedbcd5e1b1c60a5
Akademický článek
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Autor:
Jing Zhou, Khetemenee Lam, Romer A. Gonzalez-Villalobos, John J. Scarcelli, Eric Sousa, Yan Weng, Ron Kriz, Tetsuya Ishino, Darren Ferguson, Yan Zhang, Hongli L. Zhu, Boriana Tzvetkova, Valerie Clerin, Mellisa Ly, Alan C. Opsahl, Xiaotian Zhong, Qing Yao, Kim F. McClure, Kaffa Cote, Aaron M. D’Antona, Justin Cohen, Laura Lin, Annette Sievers, Weili Duan, James R. Apgar, Jason C. Rouse, Srinath Jagarlapudi, Joe Palandra, Keith A. Johnson, Suma Yaddanapudi, Richard Zollner
Publikováno v:
J Biol Chem
The fortuitously discovered antiaging membrane protein αKlotho (Klotho) is highly expressed in the kidney, and deletion of the Klotho gene in mice causes a phenotype strikingly similar to that of chronic kidney disease (CKD). Klotho functions as a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2aa95052a8ec3a97f4bd0138f1cc2d5
https://pubmed.ncbi.nlm.nih.gov/32005658
https://pubmed.ncbi.nlm.nih.gov/32005658
Autor:
Joanne Brodfuehrer, Tatyana Andreyeva, Julie Lee, Wenyan Miao, Khetemenee Lam, Jameel Syed, Rosemary Lawrence-Henderson, Josef S. Ozer, Jason Edmonds, Andrew L. Rankin, Angela Boisvert, Sean Keegan, Huilan Gao, Pratap Singh, Timothy P. LaBranche, Laird Bloom
Publikováno v:
Pharmaceutical Research. 31:635-648
Study the impact of CXCL13 neutralization on germinal center (GC) response in vivo, and build quantitative relationship between target coverage and pharmacological effects at the target tissue. An anti-CXCL13 neutralizing monoclonal antibody was dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de4d21747156c610633bb72f8d4d585
https://doi.org/10.1007/s11095-013-1185-2
https://doi.org/10.1007/s11095-013-1185-2
Autor:
Khetemenee Lam, Richard J. Cornell, Aaron M. D’Antona, Eliza Llewellyn, Ron Kriz, Jeffrey K. Marshall, Evan R. Mahan, Hongli L. Zhu, Weijun Ma, Bruno Figueroa, Annette Sievers, Xiaotian Zhong, C.M. Francis, Boriana Tzvetkova, Dana DiNino, Amy Tam, William S. Somers, Christopher Lee, Jane Guo, Richard Zollner, John J. Scarcelli, Laura Lin, Kaffa Cote, Caryl L. Meade
Publikováno v:
Biotechnology Progress. 35:e2724
Large-scale transient expression in mammalian cells is a rapid protein production technology often used to shorten overall timelines for biotherapeutics drug discovery. In this study we demonstrate transient expression in a Chinese hamster ovary (CHO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440fd7837885b71e50f94a85c80fd5f4
https://doi.org/10.1002/btpr.2724
https://doi.org/10.1002/btpr.2724
Autor:
Janet E. Paulsen, Zhijian Lu, Grace Yan, Jocelyn Sanford, Heather H. Shih, Adam Reid Root, Khetemenee Lam, Douglas C Harnish, Richard Zollner, Wei Cao, Lioudmila Tchistiakova, Mostafa Ait-Zahra, Valerie Calabro, Rita Agostinelli, Stephane Olland, Davinder Gill, Angela Robak
Publikováno v:
FEBS Journal. 276:4909-4920
LOX-1 is a scavenger receptor that functions as the primary receptor for oxidized low-density lipoprotein (OxLDL) in endothelial cells. The binding of OxLDL to LOX-1 is believed to lead to endothelial activation, dysfunction, and injury, which consti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f02942f24cebe8e4a9b6be49bf5a02f0
https://doi.org/10.1111/j.1742-4658.2009.07190.x
https://doi.org/10.1111/j.1742-4658.2009.07190.x
Autor:
Kristine Svenson, Ezio Bonvini, Alfredo Darmanin Sheehan, William J.J. Finlay, Paul A. Moore, Jocelyn Sanford, Chad May, Kelvin M. Kerns, Liqin Liu, Susan Benard, Aaron M. D’Antona, Steve Burke, Scott Gatto, Hua Li, Syd Johnson, Hans-Peter Gerber, Yinhua Yang, Edward R. Lavallie, Gurunadh Reddy Chichili, Lioudmila Tchistiakova, Tao He, Peter LaPan, Stephane Olland, William Brady, Khetemenee Lam, Cliona M. O'Sullivan, Wei Cao, Laura Lin, Adam Root, William S. Somers, Bilian Li, Ralph Alderson, Macy Jin, Lisa Racie, Lily Zhu, Weijun Ma, Caryl L. Meade, Lidia Mosyak, Wayne Stochaj, Amy King, Emma Cummins, Matthew Allister Lambert, Laird Bloom, Dianah Barrett, James R. Apgar, Maya Arai
Publikováno v:
Antibodies, Vol 5, Iss 1, p 6 (2016)
Antibodies; Volume 5; Issue 1; Pages: 6
Antibodies
Antibodies; Volume 5; Issue 1; Pages: 6
Antibodies
Bispecific antibodies offer a promising approach for the treatment of cancer but can be challenging to engineer and manufacture. Here we report the development of PF-06671008, an extended-half-life dual-affinity re-targeting (DART®) bispecific molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5727dc94b5642ceafb627d901f3b8117
https://doi.org/10.3390/antib5010006
https://doi.org/10.3390/antib5010006
Autor:
Wei, Cao, Valerie, Calabro, Adam, Root, Grace, Yan, Khetemenee, Lam, Stephane, Olland, Jocelyn, Sanford, Angela, Robak, Richard, Zollner, Zhijian, Lu, Mostafa, Ait-Zahra, Rita, Agostinelli, Lioudmila, Tchistiakova, Davinder, Gill, Douglas, Harnish, Janet, Paulsen, Heather H, Shih
Publikováno v:
The FEBS journal. 276(17)
LOX-1 is a scavenger receptor that functions as the primary receptor for oxidized low-density lipoprotein (OxLDL) in endothelial cells. The binding of OxLDL to LOX-1 is believed to lead to endothelial activation, dysfunction, and injury, which consti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23e73321d6c11ef751bcc367eeab2e29
https://pubmed.ncbi.nlm.nih.gov/19664054
https://pubmed.ncbi.nlm.nih.gov/19664054
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Autor:
Müller, Mischa R., Saunders, Kenneth, Grace, Christopher, Jin, Macy, Piche-Nicholas, Nicole, Steven, John, O'Dwyer, Ronan, Leeying Wu, Khetemenee, Lam, Vugmeyster, Yulia, Hickling, Timothy P., Tchistiakova, Lioudmila, Olland, Stephane, Gill, Davinder, Jensen, Allan, Barelle, Caroline J.
Publikováno v:
mAbs; Nov/Dec2012, Vol. 4 Issue 6, p673-685, 13p