Výsledky vyhledávání - "Kheng Sok Ung"

Cationic Sites on Granzyme B Contribute to Cytotoxicity by Promoting Its Uptake into Target Cells

Autor: Jiuru Sun, Kheng Sok Ung, Joseph A. Trapani, Diana Karambalis, James C. Whisstock, Catherina H. Bird, Phillip I. Bird

Granzyme B (GrB) is a key effector of cytotoxic lymphocyte-mediated cell death. It is delivered to target cells bound to the proteoglycan serglycin, but how it crosses the plasma membrane and accesses substrates in the cytoplasm is poorly understood.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159cfdb768bfb6df9d817e5bb96673ac
https://europepmc.org/articles/PMC1190293/

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Targeted disruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke

Autor: Harshal Hanumant Nandurkar, Peter J Crack, Kheng Sok Ung, Catherina H. Bird, Phillip I. Bird, Katrina Louise Scarff

Publikováno v: Molecular and cellular biology. 24(9)

Protease inhibitor 6 (PI-6/SERPINB6) is a widely expressed nucleocytoplasmic serpin. It inhibits granulocyte cathepsin G and neuronal neuropsin, and it is thought to protect cells from death caused by ectopic release or internalization of protease du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9368979ea3ae0a50c56bd213f41be31c
https://pubmed.ncbi.nlm.nih.gov/15082799

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A retained selection cassette increases reporter gene expression without affecting tissue distribution in SPI3 knockout/GFP knock-in mice

Autor: Phillip I. Bird, Kheng Sok Ung, Jiuru Sun, Katrina L Scarff

Publikováno v: Genesis (New York, N.Y. : 2000). 36(3)

The human serpin, proteinase inhibitor 6 (PI-6/SERPINB6), is a protease inhibitor expressed in many tissues. It inhibits a large number of proteases, including cathepsin G in granulocytes and monocytes. To determine the temporal and spatial distribut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b011d760265ee41183733b42467d69f
https://pubmed.ncbi.nlm.nih.gov/12872246

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Contribution of cationic sites to granzyme B uptake into target cells

Autor: Catherina Hedwig Bird, Marguerite Stella Buzza, Jiuru Sun, Kheng Sok Ung, James Whisstock, Trapani, Joseph A., Phillip Ian Bird

Publikováno v: Monash University

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1235c502b1454e14594e4754c1013f29
https://research.monash.edu/en/publications/b60c4408-79f5-4dcf-a94c-b7d22cf9d589

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