A Shotgun Proteomic-Based Approach with a Q-Exactive Hybrid Quadrupole-Orbitrap High-Resolution Mass Spectrometer for the Assessment of Pesticide Mixture-Induced Neurotoxicity on a 3D-Developed Neurospheroid Model from Human Brain Meningiomas: Identification of Trityl-Post-Translational Modification.

Autor: Louati K; Laboratory of Chemical, Galenic and Pharmacological Drug Development- LR12ES09, University of Monastir, Road Avicenne , 5000Monastir, Tunisia., Maalej A; Laboratory of Environmental Bioprocesses, Centre of Biotechnology of Sfax, Road of Sidi-Mansour, P.O. Box 1177 , 3018Sfax, Tunisia., Kolsi F; Department of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029Sfax, Tunisia., Kallel R; Laboratory of Pathological Anatomy and Cytology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029Sfax, Tunisia., Gdoura Y; Department of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029Sfax, Tunisia., Borni M; Department of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029Sfax, Tunisia., Hakim LS; Laboratory of Pathological Anatomy and Cytology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia., Zribi R; Faculty of Letters and Humanities, University of Sfax, Airport Road, Km 4.5, 3023 Sfax, Tunisia., Choura S; Laboratory of Environmental Bioprocesses, Centre of Biotechnology of Sfax, Road of Sidi-Mansour, P.O. Box 1177 , 3018Sfax, Tunisia., Sayadi S; Biotechnology Program, Center for Sustainable Development, College of Arts and Sciences, Qatar University, 2713 Doha, Qatar., Chamkha M; Laboratory of Environmental Bioprocesses, Centre of Biotechnology of Sfax, Road of Sidi-Mansour, P.O. Box 1177 , 3018Sfax, Tunisia., Mnif B; Department of Bacteriology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029Sfax, Tunisia., Khemakhem Z; Legal Medicine Department, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029Sfax, Tunisia., Boudawara TS; Laboratory of Pathological Anatomy and Cytology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029Sfax, Tunisia., Boudawara MZ; Department of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029Sfax, Tunisia., Bouraoui A; Laboratory of Chemical, Galenic and Pharmacological Drug Development- LR12ES09, University of Monastir, Road Avicenne , 5000Monastir, Tunisia., Kraiem J; Laboratory of Chemical, Galenic and Pharmacological Drug Development- LR12ES09, University of Monastir, Road Avicenne , 5000Monastir, Tunisia., Safta F; Laboratory of Chemical, Galenic and Pharmacological Drug Development- LR12ES09, University of Monastir, Road Avicenne , 5000Monastir, Tunisia.

Publikováno v: Journal of proteome research [J Proteome Res] 2024 Dec 06; Vol. 23 (12), pp. 5554-5576. Date of Electronic Publication: 2024 Nov 18.

Shotgun Proteomic-Based Approach with a Q-Exactive Hybrid Quadrupole-Orbitrap High-Resolution Mass Spectrometer for Protein Adductomics on a 3D Human Brain Tumor Neurospheroid Culture Model: The Identification of Adduct Formation in Calmodulin-Dependent Protein Kinase-2 and Annexin-A1 Induced by Pesticide Mixture.

Autor: Louati K; Faculty of Pharmacy, Laboratory of Pharmacology, Analytics & Galenic Drug Development-LR12ES09, University of Monastir, Road Avicenne, Monastir 5000, Tunisia., Maalej A; Laboratory of Environmental Bioprocesses, Centre of Biotechnology of Sfax, Road of Sidi-Mansour, P.O. Box 1177, Sfax 3018, Tunisia., Kolsi F; Department of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, Sfax 3089, Tunisia.; Faculty of Medicine, Avenue of Majida Boulila, University of sfax, Sfax 3029, Tunisia., Kallel R; Laboratory of Pathological Anatomy and Cytology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, Sfax 3089, Tunisia.; Faculty of Medicine, Avenue of Majida Boulila, University of sfax, Sfax 3029, Tunisia., Gdoura Y; Department of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, Sfax 3089, Tunisia.; Faculty of Medicine, Avenue of Majida Boulila, University of sfax, Sfax 3029, Tunisia., Borni M; Department of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, Sfax 3089, Tunisia.; Faculty of Medicine, Avenue of Majida Boulila, University of sfax, Sfax 3029, Tunisia., Hakim LS; Laboratory of Pathological Anatomy and Cytology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, Sfax 3089, Tunisia., Zribi R; Higher Institute of Applied Studies to Humanities of Tunis (ISEAHT), University of Tunis, 11 Road of Jebel Lakdhar, Tunis 1005, Tunisia., Choura S; Laboratory of Environmental Bioprocesses, Centre of Biotechnology of Sfax, Road of Sidi-Mansour, P.O. Box 1177, Sfax 3018, Tunisia., Sayadi S; Biotechnology Program, Center for Sustainable Development, College of Arts and Sciences, Qatar University, Doha 2713, Qatar., Chamkha M; Laboratory of Environmental Bioprocesses, Centre of Biotechnology of Sfax, Road of Sidi-Mansour, P.O. Box 1177, Sfax 3018, Tunisia., Mnif B; Department of Bacteriology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, Sfax 3089, Tunisia.; Faculty of Medicine, Avenue of Majida Boulila, University of sfax, Sfax 3029, Tunisia., Khemakhem Z; Legal Medicine Department, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, Sfax 3089, Tunisia.; Faculty of Medicine, Avenue of Majida Boulila, University of sfax, Sfax 3029, Tunisia., Boudawara TS; Laboratory of Pathological Anatomy and Cytology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, Sfax 3089, Tunisia.; Faculty of Medicine, Avenue of Majida Boulila, University of sfax, Sfax 3029, Tunisia., Boudawara MZ; Department of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, Sfax 3089, Tunisia.; Faculty of Medicine, Avenue of Majida Boulila, University of sfax, Sfax 3029, Tunisia., Safta F; Faculty of Pharmacy, Laboratory of Pharmacology, Analytics & Galenic Drug Development-LR12ES09, University of Monastir, Road Avicenne, Monastir 5000, Tunisia.

Publikováno v: Journal of proteome research [J Proteome Res] 2023 Dec 01; Vol. 22 (12), pp. 3811-3832. Date of Electronic Publication: 2023 Oct 31.

Research of Pesticide Metabolites in Human Brain Tumor Tissues by Chemometrics-Based Gas Chromatography-Mass Spectrometry Analysis for a Hypothetical Correlation between Pesticide Exposure and Risk Factor of Central Nervous System Tumors.

Autor: Louati K; Faculty of Pharmacy, Laboratory of Pharmacology, Analytics and Galenic Drug Development, LR12ES09, University of Monastir, Road Avicenne, 5000 Monastir, Tunisia., Kolsi F; Department of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029 Sfax, Tunisia., Kallel R; Laboratory of Pathological Anatomy and Cytology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029 Sfax, Tunisia., Gdoura Y; Department of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029 Sfax, Tunisia., Borni M; Department of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029 Sfax, Tunisia., Hakim LS; Laboratory of Pathological Anatomy and Cytology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029 Sfax, Tunisia., Zribi R; Higher Institute of Applied Studies to Humanities of Tunis (ISEAHT), University of Tunis, 11 Road of Jebel Lakdhar, 1005 Tunis, Tunisia., Choura S; Laboratory of Environmental Bioprocesses, Centre of Biotechnology of Sfax, Road of Sidi-Mansour, P.O. Box 1177, 3018 Sfax, Tunisia., Maalej A; Laboratory of Environmental Bioprocesses, Centre of Biotechnology of Sfax, Road of Sidi-Mansour, P.O. Box 1177, 3018 Sfax, Tunisia., Sayadi S; Biotechnology Program, Center for Sustainable Development, College of Arts and Sciences, Qatar University, 2713 Doha, Qatar., Chamkha M; Laboratory of Environmental Bioprocesses, Centre of Biotechnology of Sfax, Road of Sidi-Mansour, P.O. Box 1177, 3018 Sfax, Tunisia., Mnif B; Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029 Sfax, Tunisia., Khemakhem Z; Legal Medicine Department, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029 Sfax, Tunisia., Boudawara TS; Laboratory of Pathological Anatomy and Cytology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029 Sfax, Tunisia., Boudawara MZ; Department of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.; Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029 Sfax, Tunisia., Safta F; Faculty of Pharmacy, Laboratory of Pharmacology, Analytics and Galenic Drug Development, LR12ES09, University of Monastir, Road Avicenne, 5000 Monastir, Tunisia.

Publikováno v: ACS omega [ACS Omega] 2023 Aug 03; Vol. 8 (32), pp. 29812-29835. Date of Electronic Publication: 2023 Aug 03 (Print Publication: 2023).

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