Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Khek Chian Tham"'
Autor:
Christina Guttmann-Gruber, Josefina Piñón Hofbauer, Birgit Tockner, Victoria Reichl, Alfred Klausegger, Peter Hofbauer, Martin Wolkersdorfer, Khek-Chian Tham, Seong Soo Lim, John E. Common, Anja Diem, Katharina Ude-Schoder, Wolfgang Hitzl, Florian Lagler, Julia Reichelt, Johann W. Bauer, Roland Lang, Martin Laimer
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-9 (2021)
Abstract Background Wound management is a critical factor when treating patients with the inherited skin fragility disease dystrophic epidermolysis bullosa (DEB). Due to genetic defects in structural proteins, skin and mucous epithelia are prone to b
Externí odkaz:
https://doaj.org/article/97b40c2da2df4214a64bb591a0e70e81
Autor:
Khek-Chian Tham, Rachel Lefferdink, Kaibo Duan, Seong Soo Lim, X.F. Colin C. Wong, Erin Ibler, Benedict Wu, Hajar Abu-Zayed, Stephanie M. Rangel, Ester Del Duca, Mashkura Chowdhury, Margot Chima, Hee Jee Kim, Bernett Lee, Emma Guttman-Yassky, Amy S. Paller, John E. A. Common
Publikováno v:
British Journal of Dermatology. 187:557-570
Background The ichthyoses are rare genetic keratinizing disorders that share the characteristics of an impaired epidermal barrier and increased risk of microbial infections. Although ichthyotic diseases share a T helper (Th) 17 cell immune signature,
Autor:
Kim S. ROBINSON, Gee Ann TOH, Muhammad Jasrie FIRDAUS, Khek Chian THAM, Pritisha ROZARIO, Chrissie LIM, Ying Xiu TOH, Zhi Heng LAU, Sophie Charlotte BINDER, Jacob MAYER, Carine BONNARD, Florian I. SCHMIDT, John E. A. COMMON, Franklin L. ZHONG
NLRP1 is an innate immune sensor protein that activates inflammasome-driven pyroptotic cell death. Recent work demonstrates that human NLRP1 has evolved to sense viral infections. Whether and how human NLRP1 responds to other infectious agents is unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad76428c5948ff4f0a10289c3b7465b3
https://doi.org/10.1101/2023.01.16.524188
https://doi.org/10.1101/2023.01.16.524188
Autor:
B. Tockner, Peter Hofbauer, Seong Soo Lim, Julia Reichelt, Florian B. Lagler, Alfred Klausegger, Josefina Piñón Hofbauer, Johann W. Bauer, Katharina Ude-Schoder, John E.A. Common, Victoria Reichl, Martin Laimer, Khek-Chian Tham, Roland Lang, Martin Wolkersdorfer, Wolfgang Hitzl, Christina Guttmann-Gruber, Anja Diem
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-9 (2021)
Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases
Background Wound management is a critical factor when treating patients with the inherited skin fragility disease dystrophic epidermolysis bullosa (DEB). Due to genetic defects in structural proteins, skin and mucous epithelia are prone to blistering
Autor:
Kim S. Robinson, Gee Ann Toh, Pritisha Rozario, Rae Chua, Stefan Bauernfried, Zijin Sun, Muhammad Jasrie Firdaus, Shima Bayat, Rhea Nadkarni, Zhi Sheng Poh, Khek Chian Tham, Cassandra R. Harapas, Chrissie K. Lim, Werncui Chu, Celest W. S. Tay, Kiat Yi Tan, Tianyun Zhao, Carine Bonnard, Radoslaw Sobota, John E. Connolly, John Common, Seth L. Masters, Kaiwen W. Chen, Lena Ho, Bin Wu, Veit Hornung, Franklin L. Zhong
Publikováno v:
Science
Human NLRP1 (NACHT, LRR, and PYD domain-containing protein 1) is an innate immune sensor predominantly expressed in the skin and airway epithelium. Here, we report that human NLRP1 senses the ultraviolet B (UVB)- and toxin-induced ribotoxic stress re
Publikováno v:
DNA Repair, 38, 75-83. Elsevier
DNA mismatch repair influences the outcome of recombination events between diverging DNA sequences. Here we discuss how mismatch repair proteins are active in different homologous recombination subpathways and specific reaction steps, resulting in di
Autor:
Michael M. Cox, Joyce H.G. Lebbink, Claire Wyman, Herrie H.K. Winterwerp, Khek-Chian Tham, Nicolaas Hermans, Roland Kanaar
Publikováno v:
Molecular Cell, 51(3), 326-337. Cell Press
Molecular Cell; Vol 51
Molecular Cell; Vol 51
Homeologous recombination between divergent DNA sequences is inhibited by DNA mismatch repair. In Escherichia coli, MutS and MutL respond to DNA mismatches within recombination intermediates and prevent strand exchange via an unknown mechanism. Here,
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1797
Publikováno v:
Biophysical Journal. (3):29a
FoF1-ATP synthase (FoF1) is a complex of two rotary motors and ATP hydrolysis/synthesis reaction catalyzed by water-soluble F1 motor is tightly coupled with proton transport by membrane-embedded Fo motor. In this study, a novel method for single-mole