Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Khayachi, A."'
Autor:
Anouar Khayachi, Malak Abuzgaya, Yumin Liu, Chuan Jiao, Kurt Dejgaard, Lenka Schorova, Anusha Kamesh, Qin He, Yuting Cousineau, Alessia Pietrantonio, Nargess Farhangdoost, Charles-Etienne Castonguay, Boris Chaumette, Martin Alda, Guy A. Rouleau, Austen J. Milnerwood
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105161- (2024)
Summary: Background: Bipolar disorder (BD) is a multifactorial psychiatric illness affecting ∼1% of the global adult population. Lithium (Li), is the most effective mood stabilizer for BD but works only for a subset of patients and its mechanism of
Externí odkaz:
https://doaj.org/article/4d0848fad67e4d078f0645f0a1addb7a
Autor:
Khayachi, Anouar, Abuzgaya, Malak, Liu, Yumin, Jiao, Chuan, Dejgaard, Kurt, Schorova, Lenka, Kamesh, Anusha, He, Qin, Cousineau, Yuting, Pietrantonio, Alessia, Farhangdoost, Nargess, Castonguay, Charles-Etienne, Chaumette, Boris, Alda, Martin, Rouleau, Guy A., Milnerwood, Austen J.
Publikováno v:
In eBioMedicine June 2024 104
Autor:
Lenka Schorova, Nathalie Bedard, Anouar Khayachi, Hung-Hsiang Ho, Joao Bolivar-Pedroso, Julie Huynh, Mikaela Piccirelli, Yifei Wang, Marie Plourde, Wen Luo, Esther del Cid-Pellitero, Irina Shlaifer, María José Castellanos-Montiel, Ziqi Yu, Dulce Valeria Carrillo Valenzuela, María Lacalle-Aurioles, Anita Kriz, Yihong Ye, Thomas M. Durcan, Simon S. Wing
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-16 (2023)
Abstract The USP19 deubiquitinase is found in a locus associated with Parkinson’s Disease (PD), interacts with chaperonins, and promotes secretion of α-synuclein (α-syn) through the misfolding-associated protein secretion (MAPS) pathway. Since th
Externí odkaz:
https://doaj.org/article/976adaa7653347f3b014022aafcd2739
Autor:
Madanlal, Dhanyaasri, Guinard, Christian, Nuñez, Vanessa Pardo, Becker, Suzanna, Garnham, Julie, Khayachi, Anouar, Léger, Simon, O'Donovan, Claire, Singh, Selena, Stern, Shani, Slaney, Claire, Trappenberg, Thomas, Alda, Martin, Nunes, Abraham
Publikováno v:
In Journal of Affective Disorders 15 April 2024 351:49-57
Autor:
Charles-Etienne Castonguay, Calwing Liao, Anouar Khayachi, Yumin Liu, Miranda Medeiros, Gabrielle Houle, Jay P. Ross, Patrick A. Dion, Guy A. Rouleau
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract Essential tremor (ET) is one of the most common movement disorders, affecting nearly 5% of individuals over 65 years old. Despite this, few genetic risk loci for ET have been identified. Recent advances in pharmacogenomics have previously be
Externí odkaz:
https://doaj.org/article/a039ede0ce6a42c794df849f2ee72262
Publikováno v:
In Neuroscience and Biobehavioral Reviews August 2021 127:424-445
Autor:
Marta Prieto, Alessandra Folci, Gwénola Poupon, Sara Schiavi, Valeria Buzzelli, Marie Pronot, Urielle François, Paula Pousinha, Norma Lattuada, Sophie Abelanet, Sara Castagnola, Magda Chafai, Anouar Khayachi, Carole Gwizdek, Frédéric Brau, Emmanuel Deval, Maura Francolini, Barbara Bardoni, Yann Humeau, Viviana Trezza, Stéphane Martin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The R138Q mutation in the Fragile X Mental Retardation 1 (FMR1) gene has been associated with Fragile X syndrome (FXS). Here, the authors present a Fmr1 R138Q Knock-In mouse model and show that R138Q mutation results in impaired long-term potentiatio
Externí odkaz:
https://doaj.org/article/1f547051b6104cb2ae2a8dd5047148af
Autor:
Jean-Pierre Clément, Laila Al-Alwan, Stephen D. Glasgow, Avya Stolow, Yi Ding, Thaiany Quevedo Melo, Anouar Khayachi, Yumin Liu, Markus Hellmund, Rainer Haag, Austen J Milnerwood, Peter Grütter, Timothy E. Kennedy
Publikováno v:
ASN Neuro, Vol 14 (2022)
Long-term stable cell culture is a critical tool to better understand cell function. Most adherent cell culture models require a polymer substrate coating of poly-lysine or poly-ornithine for the cells to adhere and survive. However, polypeptide-base
Externí odkaz:
https://doaj.org/article/70444c970cce4ca89c141457c330fdb2
Autor:
Inés González-Calvo, Keerthana Iyer, Mélanie Carquin, Anouar Khayachi, Fernando A Giuliani, Séverine M Sigoillot, Jean Vincent, Martial Séveno, Maxime Veleanu, Sylvana Tahraoui, Mélanie Albert, Oana Vigy, Célia Bosso-Lefèvre, Yann Nadjar, Andréa Dumoulin, Antoine Triller, Jean-Louis Bessereau, Laure Rondi-Reig, Philippe Isope, Fekrije Selimi
Publikováno v:
eLife, Vol 10 (2021)
Fine control of protein stoichiometry at synapses underlies brain function and plasticity. How proteostasis is controlled independently for each type of synaptic protein in a synapse-specific and activity-dependent manner remains unclear. Here, we sh
Externí odkaz:
https://doaj.org/article/01bd3175794d47878ad8b245d0150a1d
Autor:
Anouar Khayachi, Carole Gwizdek, Gwénola Poupon, Damien Alcor, Magda Chafai, Frédéric Cassé, Thomas Maurin, Marta Prieto, Alessandra Folci, Fabienne De Graeve, Sara Castagnola, Romain Gautier, Lenka Schorova, Céline Loriol, Marie Pronot, Florence Besse, Frédéric Brau, Emmanuel Deval, Barbara Bardoni, Stéphane Martin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Fragile X syndrome patients display intellectual disability and autism, caused by mutations in the RNA-binding protein fragile X mental retardation protein (FMRP). Here, the authors show that FMRP sumoylation is required for regulating spine density
Externí odkaz:
https://doaj.org/article/57e3d66daa9b4a92b4183ee79455e739