Výsledky vyhledávání - "Khay-Guan Yeoh"

Akademický článek

Accuracy Goals in Predicting Preoperative Lymph Node Metastasis for T1 Colorectal Cancer Resected Endoscopically

Autor: Katsuro Ichimasa, Shin-ei Kudo, Masashi Misawa, Khay Guan Yeoh, Tetsuo Nemoto, Yuta Kouyama, Yuki Takashina, Hideyuki Miyachi

Publikováno v: Gut and Liver, Vol 18, Iss 5, Pp 803-806 (2024)

Submucosal invasive (T1) colorectal cancer is a significant clinical management challenge, with an estimated 10% of patients developing extraintestinal lymph node metastasis. This condition necessitates surgical resection along with lymph node dissec

Externí odkaz: https://doaj.org/article/3c37a1baf1ec44dca6e3b4bb7545637e

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Akademický článek

Challenges in Implementing Endoscopic Resection for T2 Colorectal Cancer

Autor: Katsuro Ichimasa, Shin-ei Kudo, Ker-Kan Tan, Jonathan Wei Jie Lee, Khay Guan Yeoh

Publikováno v: Gut and Liver, Vol 18, Iss 2, Pp 218-221 (2024)

The current standard treatment for muscularis propria-invasive (T2) colorectal cancer is surgical colectomy with lymph node dissection. With the advent of new endoscopic resection techniques, such as endoscopic full-thickness resection or endoscopic

Externí odkaz: https://doaj.org/article/bb5991d152554a57a1705fa849642f0d

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Akademický článek

Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Here the authors identify distinct mechanisms by which domain-specific p53 mutations activate cancer cell growth via the epidermal growth factor receptor (EGFR). These mechanisms affect sensitivity to EGFR inhibitors, opening avenues for targeted the

Externí odkaz: https://doaj.org/article/887b89f317fb487d8e09152d6d299ac4

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Akademický článek

A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the StomachSummary

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 5, Pp 1317-1345 (2022)

Background & Aims: RUNX transcription factors play pivotal roles in embryonic development and neoplasia. We previously identified the single missense mutation R122C in RUNX3 from human gastric cancer. However, how RUNX3R122C mutation disrupts stem ce

Externí odkaz: https://doaj.org/article/b05baf92b97a4f7b8f43a64fb91a7900

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Akademický článek

Oncofetal protein IGF2BP1 regulates IQGAP3 expression to maintain stem cell potential in cancer

Autor: Khine Myint, Linda Shyue Huey Chuang, Yu Xuan Teh, Nur Astiana Mawan, Edward Jizhong Shi, Michelle Meng Huang Mok, Napat Nuttonmanit, Junichi Matsuo, Ying Li, Henry Yang, Atsushi Okabe, Atsushi Kaneda, Motomi Osato, Jimmy Bok-Yan So, Wei Peng Yong, Patrick Tan, Khay Guan Yeoh, Yoshiaki Ito

Publikováno v: iScience, Vol 25, Iss 10, Pp 105194- (2022)

Summary: We reported earlier that IQGAP3 is an important stem cell factor in rapidly proliferating isthmus stem cells in the stomach and that IQGAP3 expression is robustly induced in terminally differentiated chief cells and de-differentiated cells f

Externí odkaz: https://doaj.org/article/75ca2ac94f5b4c3b9d3f7a5561031c57

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