Zobrazeno 1 - 10
of 309
pro vyhledávání: '"Khawla S. Al-Kuraya"'
Autor:
Pratheesh Kumar Poyil, Abdul K. Siraj, Divya Padmaja, Sandeep Kumar Parvathareddy, Saravanan Thangavel, Khadija Alobaisi, Roxanne Diaz, Rafia Begum, Wael Haqawi, Saif S. Al‐Sobhi, Fouad Al‐Dayel, Khawla S. Al‐Kuraya
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 691-706 (2024)
Polo‐like kinase 1 (PLK1; also known as serine/threonine‐protein kinase PLK1) serves as a central player in cell proliferation, exerting critical regulatory roles in mitotic processes and cell survival. We conducted an analysis of PLK1 protein ex
Externí odkaz:
https://doaj.org/article/57d1afe46d474a6699d90c95cfe8d3a3
Autor:
Sandeep Kumar Parvathareddy, Abdul K. Siraj, Nabil Siraj, Saeeda O. Ahmed, Maha Al-Rasheed, Zeeshan Qadri, Khawar Siddiqui, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
BackgroundRadioactive iodine refractory differentiated thyroid cancer (RAIR-DTC) has received increasing attention due to its poor prognosis. However, outcomes may vary among patients with RAIR-DTC. The role of clinico-pathological and molecular prog
Externí odkaz:
https://doaj.org/article/17ae1281bd4443f99851cf05fc25603d
Autor:
Rong Bu, Abdul K. Siraj, Maha Al-Rasheed, Kaleem Iqbal, Saud Azam, Zeeshan Qadri, Wael Haqawi, Asma Tulbah, Fouad Al-Dayel, Osama Almalik, Khawla S. Al-Kuraya
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Breast cancer (BC) is the most prevalent malignancy among women worldwide with germline pathogenic variants/likely pathogenic variants (PVs/LPVs) in BRCA1/2 accounting for a large portion of hereditary cases. Recently, heterozygous PVs/LPVs
Externí odkaz:
https://doaj.org/article/0488b7354eda4a4ca492a51ccc846bac
Autor:
Abdul K. Siraj, Sandeep Kumar Parvathareddy, Maha Al-Rasheed, Padmanaban Annaiyappanaidu, Nabil Siraj, Maximilian Lennartz, Saif S. Al-Sobhi, Fouad Al-Dayel, Guido Sauter, Khawla S. Al-Kuraya
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Papillary Thyroid Cancer (PTC) is the most common type of thyroid cancer. The membrane-associated glycoprotein cadherin-16 (CDH16) plays a significant role in the embryonal development of thyroid follicles and cell adhesion. Previous studies
Externí odkaz:
https://doaj.org/article/6d312f1849224cff95352788d586c8a1
Autor:
Maximilian Lennartz, Henrietta Csomós, Viktoria Chirico, Sören Weidemann, Natalia Gorbokon, Anne Menz, Franziska Büscheck, Claudia Hube-Magg, Doris Höflmayer, Christian Bernreuther, Niclas C. Blessin, Patrick Lebok, Guido Sauter, Stefan Steurer, Eike Burandt, David Dum, Till Krech, Ronald Simon, Sarah Minner, Frank Jacobsen, Till S. Clauditz, Andreas M. Luebke, Abdul Khalid Siraj, Fouad Al-Dayel, Khawla S. Al-Kuraya, Andrea Hinsch
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Cadherin-16 (CDH16) plays a role in the embryonal development in kidney and thyroid. Downregulation of CDH16 RNA was found in papillary carcinomas of the thyroid. To determine the expression of CDH16 in tumors and to assess the diagnostic ut
Externí odkaz:
https://doaj.org/article/bbfd9ebdf3b84c049d5620f1b25266ec
Autor:
Pratheesh Kumar Poyil, Abdul K. Siraj, Divya Padmaja, Sandeep Kumar Parvathareddy, Roxanne Diaz, Saravanan Thangavel, Rafia Begum, Wael Haqawi, Falah Hassan Al‐Mohanna, Saif S. Al‐Sobhi, Fouad Al‐Dayel, Khawla S. Al‐Kuraya
Publikováno v:
Molecular Oncology, Vol 17, Iss 7, Pp 1324-1342 (2023)
Furin belongs to the pro‐protein convertases (PCs) family and its aberrant expression has been documented in various types of cancers; however, its role in thyroid cancer remains unclear. We investigated the expression of furin in a large cohort of
Externí odkaz:
https://doaj.org/article/b58013fb55f74e7cbcb973ffa45504ad
Autor:
Abdul K. Siraj, Rong Bu, Sandeep Kumar Parvathareddy, Kaleem Iqbal, Saud Azam, Zeeshan Qadri, Maha Al-Rasheed, Wael Haqawi, Mark Diaz, Ingrid G. Victoria, Ismail A. Al-Badawi, Asma Tulbah, Fouad Al-Dayel, Dahish Ajarim, Khawla S. Al-Kuraya
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract The PALB2 gene is a breast cancer (BC) and ovarian cancer (OC) predisposition gene involved in the homologous recombination repair pathway. However, the prevalence and clinicopathological association of PALB2 pathogenic/likely pathogenic (PV
Externí odkaz:
https://doaj.org/article/0c97e2f47b824050854ac2fed92effc0
Autor:
Abdul K. Siraj, Pratheesh Kumar Poyil, Divya Padmaja, Sandeep Kumar Parvathareddy, Khadija Alobaisi, Saravanan Thangavel, Roxanne Diaz, Rafia Begum, Osama Almalik, Fouad Al-Dayel, Khawla S. Al-Kuraya
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
BackgroundDespite advancements in treatment approaches, patients diagnosed with aggressive breast cancer (BC) subtypes typically face an unfavorable prognosis. Globally, these cancers continue to pose a significant threat to women's health, leading t
Externí odkaz:
https://doaj.org/article/86c90ec4e3254f31aa9489c0642a515e
Recurrent Middle Eastern Differentiated Thyroid Carcinoma Has Worse Outcomes Than Persistent Disease
Autor:
Sandeep Kumar Parvathareddy, Abdul K. Siraj, Padmanaban Annaiyappanaidu, Saeeda O. Ahmed, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Publikováno v:
Journal of Clinical Medicine, Vol 13, Iss 7, p 1877 (2024)
Background: Despite the excellent prognosis of differentiated thyroid carcinoma (DTC), recurrent and persistent disease remain major challenges. Emerging studies to differentiate between recurrent and persistent disease are controversial, with studie
Externí odkaz:
https://doaj.org/article/b0a67720400245eaae95dea35e8dcb80
Autor:
Sandeep Kumar Parvathareddy, Abdul K. Siraj, Padmanaban Annaiyappanaidu, Nabil Siraj, Maha Al-Rasheed, Wael Al-Haqawi, Zeeshan Qadri, Khawar Siddiqui, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundDespite their excellent prognosis, children and young adults (CAYA) with differentiated thyroid cancer (DTC) tend to have more frequent occurrence of distant metastasis (DM) compared to adult DTC. Data about DM in CAYA from Middle Eastern e
Externí odkaz:
https://doaj.org/article/8bb2fe248a9a4b3dae9abe15f0572fe8