Zobrazeno 1 - 10
of 309
pro vyhledávání: '"Khawla S Al-Kuraya"'
Autor:
Sandeep Kumar Parvathareddy, Abdul K Siraj, Zeeshan Qadri, Saeeda O Ahmed, Felisa DeVera, Saif Al-Sobhi, Fouad Al-Dayel, Khawla S Al-Kuraya
Publikováno v:
Endocrine Connections, Vol 11, Iss 2, Pp 1-11 (2022)
Objective: Recently, lymph node ratio (LNR) has emerged as an alternative to American Joint Committee on Cancer (AJCC) N stage, with superior prognostic value. The utility of LNR in Middle Eastern papillary thyroid carcinoma (PTC) remains unknown. Th
Externí odkaz:
https://doaj.org/article/2880af393fd647caa4aead8724bebe5c
Autor:
Abdul K Siraj, Rong Bu, Maham Arshad, Kaleem Iqbal, Sandeep Kumar Parvathareddy, Tariq Masoodi, Laila Omar Ghazwani, Saif S Al-Sobhi, Fouad Al-Dayel, Khawla S Al-Kuraya
Publikováno v:
Endocrine Connections, Vol 9, Iss 9, Pp 923-932 (2020)
Thyroid cancer is the most frequent endocrine cancer with an increasing incidence rate worldwide and is the second most common malignancy among females in Saudi Arabia. Papillary thyroid cancer (PTC) is the most common subtype. Germline pathogenic va
Externí odkaz:
https://doaj.org/article/8eaedde4fe3248cc8acc0745431f8ef6
Autor:
Pratheesh Kumar Poyil, Abdul K. Siraj, Divya Padmaja, Sandeep Kumar Parvathareddy, Saravanan Thangavel, Khadija Alobaisi, Roxanne Diaz, Rafia Begum, Wael Haqawi, Saif S. Al‐Sobhi, Fouad Al‐Dayel, Khawla S. Al‐Kuraya
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 691-706 (2024)
Polo‐like kinase 1 (PLK1; also known as serine/threonine‐protein kinase PLK1) serves as a central player in cell proliferation, exerting critical regulatory roles in mitotic processes and cell survival. We conducted an analysis of PLK1 protein ex
Externí odkaz:
https://doaj.org/article/57d1afe46d474a6699d90c95cfe8d3a3
Autor:
Sandeep Kumar Parvathareddy, Abdul K. Siraj, Nabil Siraj, Saeeda O. Ahmed, Maha Al-Rasheed, Zeeshan Qadri, Khawar Siddiqui, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
BackgroundRadioactive iodine refractory differentiated thyroid cancer (RAIR-DTC) has received increasing attention due to its poor prognosis. However, outcomes may vary among patients with RAIR-DTC. The role of clinico-pathological and molecular prog
Externí odkaz:
https://doaj.org/article/17ae1281bd4443f99851cf05fc25603d
Autor:
Azhar R Hussain, Shahab Uddin, Maqbool Ahmed, Fouad Al-Dayel, Prashant P Bavi, Khawla S Al-Kuraya
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60540 (2013)
Activated B-cell lymphoma (ABC), one of the three subtypes of Diffuse Large B-cell Lymphoma (DLBCL) has the worst survival rate after upfront chemotherapy and is characterized by constitutively activated NFκB. We therefore studied the role of NFκB
Externí odkaz:
https://doaj.org/article/b8363688625c4170b8e6bde00b6f9f3c
Autor:
Rong Bu, Abdul K. Siraj, Maha Al-Rasheed, Kaleem Iqbal, Saud Azam, Zeeshan Qadri, Wael Haqawi, Asma Tulbah, Fouad Al-Dayel, Osama Almalik, Khawla S. Al-Kuraya
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Breast cancer (BC) is the most prevalent malignancy among women worldwide with germline pathogenic variants/likely pathogenic variants (PVs/LPVs) in BRCA1/2 accounting for a large portion of hereditary cases. Recently, heterozygous PVs/LPVs
Externí odkaz:
https://doaj.org/article/0488b7354eda4a4ca492a51ccc846bac
Autor:
Azhar R Hussain, Saeeda O Ahmed, Maqbool Ahmed, Omar S Khan, Sally Al Abdulmohsen, Leonidas C Platanias, Khawla S Al-Kuraya, Shahab Uddin
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39945 (2012)
A number of constitutively activated signaling pathways play critical roles in the survival and growth of primary effusion lymphoma cells (PELs) including NFkB and PI3/AKT kinase cascades. NFkBis constitutively activated in a number of malignancies,
Externí odkaz:
https://doaj.org/article/819a721147874dbdaee01691b9f7035d
Autor:
Azhar R Hussain, Shahab Uddin, Rong Bu, Omar S Khan, Saeeda O Ahmed, Maqbool Ahmed, Khawla S Al-Kuraya
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24703 (2011)
BackgroundWe have recently shown that deregulation PI3-kinase/AKT survival pathway plays an important role in pathogenesis of diffuse large B cell lymphoma (DLBCL). In an attempt to identify newer therapeutic agents, we investigated the role of Resve
Externí odkaz:
https://doaj.org/article/07d26e01214c4ad9a8c821ce8c34d555
Autor:
Abdul K. Siraj, Sandeep Kumar Parvathareddy, Maha Al-Rasheed, Padmanaban Annaiyappanaidu, Nabil Siraj, Maximilian Lennartz, Saif S. Al-Sobhi, Fouad Al-Dayel, Guido Sauter, Khawla S. Al-Kuraya
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Papillary Thyroid Cancer (PTC) is the most common type of thyroid cancer. The membrane-associated glycoprotein cadherin-16 (CDH16) plays a significant role in the embryonal development of thyroid follicles and cell adhesion. Previous studies
Externí odkaz:
https://doaj.org/article/6d312f1849224cff95352788d586c8a1
Autor:
Maximilian Lennartz, Henrietta Csomós, Viktoria Chirico, Sören Weidemann, Natalia Gorbokon, Anne Menz, Franziska Büscheck, Claudia Hube-Magg, Doris Höflmayer, Christian Bernreuther, Niclas C. Blessin, Patrick Lebok, Guido Sauter, Stefan Steurer, Eike Burandt, David Dum, Till Krech, Ronald Simon, Sarah Minner, Frank Jacobsen, Till S. Clauditz, Andreas M. Luebke, Abdul Khalid Siraj, Fouad Al-Dayel, Khawla S. Al-Kuraya, Andrea Hinsch
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Cadherin-16 (CDH16) plays a role in the embryonal development in kidney and thyroid. Downregulation of CDH16 RNA was found in papillary carcinomas of the thyroid. To determine the expression of CDH16 in tumors and to assess the diagnostic ut
Externí odkaz:
https://doaj.org/article/bbfd9ebdf3b84c049d5620f1b25266ec