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Data from Forced Dimerization Increases the Activity of ΔEGFR/EGFRvIII and Enhances Its Oncogenicity
Delta epidermal growth factor receptor (ΔEGFR), an in-frame deletion mutant of the extracellular ligand-binding domain, which occurs in about 30% of glioblastoma, is a potent oncogene that promotes tumor growth and progression. The signaling of ΔEG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12077d834b31d1758eca62f0f712f5f5
https://doi.org/10.1158/1541-7786.c.6542146.v1
https://doi.org/10.1158/1541-7786.c.6542146.v1
Autor:
Amy B. Heimberger, Michael Curran, Shulin Li, James Long, Adam M. Sonabend, Fernando Benavides, Gregory N. Fuller, Jun Wei, Ling-Yuan Kong, Yuhui Yang, Tiffany A. Doucette, Daniel Zamler, Xiaoyang Ling, Anantha Marisetty, Aria Sabbagh, Martina Ott, Khatri Latha, Ganesh Rao
Purpose:Anti-programmed cell death protein 1 (PD-1) therapy has demonstrated inconsistent therapeutic results in patients with glioblastoma (GBM) including those with profound impairments in CD8 T-cell effector responses.Experimental Design:We ablate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c65893bdfeb0b13d7f1f59497916702
https://doi.org/10.1158/1078-0432.c.6529808.v1
https://doi.org/10.1158/1078-0432.c.6529808.v1
Autor:
Amy B. Heimberger, Michael Curran, Shulin Li, James Long, Adam M. Sonabend, Fernando Benavides, Gregory N. Fuller, Jun Wei, Ling-Yuan Kong, Yuhui Yang, Tiffany A. Doucette, Daniel Zamler, Xiaoyang Ling, Anantha Marisetty, Aria Sabbagh, Martina Ott, Khatri Latha, Ganesh Rao
Supplementary Figures 1-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260be9e56ae566322a75698a27e52fd6
https://doi.org/10.1158/1078-0432.22477946
https://doi.org/10.1158/1078-0432.22477946
Autor:
A. Basit Khan, Sungho Lee, Akdes Serin Harmanci, Rajan Patel, Khatri Latha, Yuhui Yang, Anantha Marisetty, Hyun‐Kyoung Lee, Amy B. Heimberger, Gregory N. Fuller, Benjamin Deneen, Ganesh Rao
Publikováno v:
Int J Cancer
Glioblastoma (GBM) is the most common primary intracranial malignant tumor and consists of three molecular subtypes: proneural (PN), mesenchymal (MES) and classical (CL). Transition between PN to MES subtypes (PMT) is the glioma analog of the epithel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940f930b3c863663b9a2e7a8170adc4e
https://pubmed.ncbi.nlm.nih.gov/36250346
https://pubmed.ncbi.nlm.nih.gov/36250346
