Deep phenotyping the right ventricle to establish translational MRI biomarkers for characterization of adaptive and maladaptive states in pulmonary hypertension.

Autor: Baxan, Nicoleta, Zhao, Lin, Ashek, Ali, Niglas, Marili, Wang, Dingyi, Khassafi, Fatemeh, Sabrin, Farah, Dubois, Olivier, Chen, Chien-Nien, Pullamsetti, Soni Savai, Wilkins, Martin, Zhao, Lan

Publikováno v: Scientific Reports; 11/30/2024, Vol. 14 Issue 1, p1-17, 17p

Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling.

Autor: Nayakanti, Sreenath Reddy, Friedrich, Aleksandra, Sarode, Poonam, Jafari, Leili, Maroli, Giovanni, Boehm, Mario, Bourgeois, Alice, Grobs, Yann, Khassafi, Fatemeh, Kuenne, Carsten, Guenther, Stefan, Dabral, Swati, Wilhelm, Jochen, Weiss, Astrid, Wietelmann, Astrid, Kojonazarov, Baktybek, Janssen, Wiebke, Looso, Mario, de Man, Frances, Provencher, Steeve

Publikováno v: Circulation Research; 5/26/2023, Vol. 132 Issue 11, p1468-1485, 18p

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Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension.

Autor: Khassafi F; Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany., Chelladurai P; Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany., Valasarajan C; Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany., Nayakanti SR; Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Martineau S; Pulmonary Hypertension and Vascular Biology Research Group of Quebec Heart and Lung Institute, Department of Medicine, Laval University, Quebec, Canada., Sommer N; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany.; Institute for Lung Health (ILH), Justus-Liebig University, Giessen, Germany., Yokokawa T; Pulmonary Hypertension and Vascular Biology Research Group of Quebec Heart and Lung Institute, Department of Medicine, Laval University, Quebec, Canada.; Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan., Boucherat O; Pulmonary Hypertension and Vascular Biology Research Group of Quebec Heart and Lung Institute, Department of Medicine, Laval University, Quebec, Canada., Kamal A; European Molecular Biology Laboratory, Heidelberg, Germany., Kiely DG; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.; Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.; NIHR Biomedical Research Center, Sheffield, UK., Swift AJ; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.; NIHR Biomedical Research Center, Sheffield, UK., Alabed S; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.; NIHR Biomedical Research Center, Sheffield, UK., Omura J; Pulmonary Hypertension and Vascular Biology Research Group of Quebec Heart and Lung Institute, Department of Medicine, Laval University, Quebec, Canada., Breuils-Bonnet S; Pulmonary Hypertension and Vascular Biology Research Group of Quebec Heart and Lung Institute, Department of Medicine, Laval University, Quebec, Canada., Kuenne C; Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Potus F; Pulmonary Hypertension and Vascular Biology Research Group of Quebec Heart and Lung Institute, Department of Medicine, Laval University, Quebec, Canada., Günther S; Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Savai R; Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany.; Institute for Lung Health (ILH), Justus-Liebig University, Giessen, Germany., Seeger W; Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany.; Institute for Lung Health (ILH), Justus-Liebig University, Giessen, Germany., Looso M; Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Lawrie A; National Heart and Lung Institute, Imperial College London, London, UK., Zaugg JB; European Molecular Biology Laboratory, Heidelberg, Germany., Tello K; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany.; Institute for Lung Health (ILH), Justus-Liebig University, Giessen, Germany., Provencher S; Pulmonary Hypertension and Vascular Biology Research Group of Quebec Heart and Lung Institute, Department of Medicine, Laval University, Quebec, Canada., Bonnet S; Pulmonary Hypertension and Vascular Biology Research Group of Quebec Heart and Lung Institute, Department of Medicine, Laval University, Quebec, Canada. sebastien.bonnet@criucpq.ulaval.ca., Pullamsetti SS; Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany. soni.pullamsetti@mpi-bn.mpg.de.; Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany. soni.pullamsetti@mpi-bn.mpg.de.; Institute for Lung Health (ILH), Justus-Liebig University, Giessen, Germany. soni.pullamsetti@mpi-bn.mpg.de.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2023 Oct; Vol. 2 (10), pp. 917-936. Date of Electronic Publication: 2023 Sep 28.