Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Khanichi N. Charles"'
Autor:
Khanichi N. Charles, Janis E. Shackelford, Phyllis L. Faust, Steven J. Fliesler, Herbert Stangl, Werner J. Kovacs
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Cholesterol biosynthesis is a multi-step process involving several subcellular compartments, including peroxisomes. Cells adjust their sterol content by both transcriptional and post-transcriptional feedback regulation, for which sterol regulatory el
Externí odkaz:
https://doaj.org/article/f0eb6466aaf148c3937de0abf3ce0f21
Autor:
Tanja Eberhart, Miriam J. Schönenberger, Katharina M. Walter, Khanichi N. Charles, Phyllis L. Faust, Werner J. Kovacs
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Ketohexokinase (KHK) is the first and rate-limiting enzyme of fructose metabolism. Expression of the two alternatively spliced KHK isoforms, KHK-A and KHK-C, is tissue-specific and KHK-C is predominantly expressed in liver, kidney and intestine and r
Externí odkaz:
https://doaj.org/article/5912013fb27c4b769f23799730e58776
Autor:
Khanichi N. Charles, Min-Dian Li, Feyza Engin, Ana Paula Arruda, Karen Inouye, Gökhan S. Hotamisligil
Publikováno v:
Cell Reports, Vol 21, Iss 2, Pp 393-402 (2017)
Summary: Deterioration of metabolic health is a hallmark of aging and generally assumed to be detrimental to longevity. Exposure to a high-calorie diet impairs metabolism and accelerates aging; conversely, calorie restriction (CR) prevents age-relate
Externí odkaz:
https://doaj.org/article/10f37773f5ae412db8a0de986dbdafef
Autor:
Min-Dian Li, Ana Paula Arruda, Feyza Engin, Gökhan S. Hotamisligil, Karen Inouye, Khanichi N. Charles
Publikováno v:
Cell Reports, Vol 21, Iss 2, Pp 393-402 (2017)
Summary: Deterioration of metabolic health is a hallmark of aging and generally assumed to be detrimental to longevity. Exposure to a high-calorie diet impairs metabolism and accelerates aging; conversely, calorie restriction (CR) prevents age-relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d247423072611b74e99fd33265b5ae6
https://europepmc.org/articles/PMC5682597/
https://europepmc.org/articles/PMC5682597/
Autor:
Liza Makowski, Khanichi N. Charles, Gökhan S. Hotamisligil, Sergio Fazio, Melinda E. Snitow, Steven M. Watkins, Ebru Erbay, MacRae F. Linton, Vladimir R. Babaev, Michelle M. Wiest, Jared R. Mayers
Publikováno v:
Nature medicine
Macrophages show endoplasmic reticulum (ER) stress when exposed to lipotoxic signals associated with atherosclerosis, although the pathophysiological importance and the underlying mechanisms of this phenomenon remain unknown. Here we show that mitiga
Autor:
Skaidrite K. Krisans, Steven J. Fliesler, Janis E. Shackelford, M.J. Richards, Thomas M. Wikander, Katharina M. Walter, Werner J. Kovacs, Phyllis L. Faust, Khanichi N. Charles
Publikováno v:
Biochim. Biophys. Acta Mol. Cell Biol. Lipids
Disruption of the Pex2 gene leads to peroxisome deficiency and widespread metabolic dysfunction. We previously demonstrated that peroxisomes are critical for maintaining cholesterol homeostasis, using peroxisome-deficient Pex2(-/-) mice on a hybrid S
Autor:
Vladimir R. Babaev, Gökhan S. Hotamisligil, Khanichi N. Charles, Steven M. Watkins, Michelle M. Wiest, Jared R. Mayers, MacRae F. Linton, Sergio Fazio, Ebru Erbay, Melinda E. Snitow, Liza Makowski
Publikováno v:
Nature Medicine. 16:237-237