Design and evaluation of [¹⁸F]CHDI-650 as a positron emission tomography ligand to image mutant Huntingtin aggregates

Autor: Liu, Longbin, Johnson, Peter D., Prime, Michael E., Khetarpal, Vinod, Brown, Christopher J., Anzillotti, Luca, Bertoglio, Daniele, Chen, Xuemei, Coe, Samuel, Davis, Randall, Dickie, Anthony P., Esposito, Simone, Gadouleau, Elise, Giles, Paul R., Greenaway, Catherine, Haber, James, Halldin, Christer, Haller, Scott, Hayes, Sarah, Herbst, Todd, Herrmann, Frank, Hessmann, Manuela, Hsai, Ming Min, Khani, Yaser, Kotey, Adrian, Lembo, Angelo, Mangette, John E., Marriner, Gwendolyn A., Marston, Richard W., Mills, Matthew R., Monteagudo, Edith, Forsberg-Moren, Anton, Nag, Sangram, Orsatti, Laura, Sandiego, Christine, Schaertl, Sabine, Sproston, Joanne, Staelens, Steven, Tookey, Jack, Turner, Penelope A., Vecchi, Andrea, Veneziano, Maria, Munoz-Sanjuan, Ignacio, Bard, Jonathan, Dominguez, Celia

Publikováno v: Journal of medicinal chemistry

Therapeutic interventions are being developed for Huntington's disease (HD), a hallmark of which is mutant huntingtin protein (mHTT) aggregates. Following the advancement to human testing of two [11C]-PET ligands for aggregated mHTT, attributes for f

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https://hdl.handle.net/10067/1931800151162165141

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Design and Evaluation of [ ¹⁸ F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates.

Autor: Liu L; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Johnson PD; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Prime ME; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Khetarpal V; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Brown CJ; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Anzillotti L; Experimental Pharmacology Department, IRBM S.p.A., Via Pontina km 30,600, Pomezia, Roma 00071, Italy., Bertoglio D; Molecular Imaging Center Antwerp (MICA), University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium., Chen X; Curia Global, Inc., 1001 Main Street, Buffalo, New York 14203, United States., Coe S; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Davis R; Curia Global, Inc., 1001 Main Street, Buffalo, New York 14203, United States., Dickie AP; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Esposito S; Experimental Pharmacology Department, IRBM S.p.A., Via Pontina km 30,600, Pomezia, Roma 00071, Italy., Gadouleau E; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Giles PR; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Greenaway C; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Haber J; Curia Global, Inc., 1001 Main Street, Buffalo, New York 14203, United States., Halldin C; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, Stockholm S-17176, Sweden., Haller S; Charles River Laboratories, 54943 North Main Street, Mattawan, Michigan 49071, United States., Hayes S; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Herbst T; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Herrmann F; Evotec SE, Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany., Heßmann M; Evotec SE, Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany., Hsai MM; Curia Global, Inc., 1001 Main Street, Buffalo, New York 14203, United States., Khani Y; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, Stockholm S-17176, Sweden., Kotey A; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Lembo A; Experimental Pharmacology Department, IRBM S.p.A., Via Pontina km 30,600, Pomezia, Roma 00071, Italy., Mangette JE; Curia Global, Inc., 1001 Main Street, Buffalo, New York 14203, United States., Marriner GA; Charles River Laboratories, 54943 North Main Street, Mattawan, Michigan 49071, United States., Marston RW; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Mills MR; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Monteagudo E; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Forsberg-Morén A; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, Stockholm S-17176, Sweden., Nag S; Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, Karolinska Institutet, Stockholm S-17176, Sweden., Orsatti L; Experimental Pharmacology Department, IRBM S.p.A., Via Pontina km 30,600, Pomezia, Roma 00071, Italy., Sandiego C; Invicro, 60 Temple St, Ste 8A, New Haven, Connecticut 06510, United States., Schaertl S; Evotec SE, Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany., Sproston J; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Staelens S; Molecular Imaging Center Antwerp (MICA), University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium., Tookey J; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Turner PA; Evotec (U.K.) Ltd, 114 Innovation Drive, Milton Park, Abingdon OX14 4RZ, U.K., Vecchi A; Experimental Pharmacology Department, IRBM S.p.A., Via Pontina km 30,600, Pomezia, Roma 00071, Italy., Veneziano M; Experimental Pharmacology Department, IRBM S.p.A., Via Pontina km 30,600, Pomezia, Roma 00071, Italy., Muñoz-Sanjuan I; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Bard J; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States., Dominguez C; CHDI Management/CHDI Foundation, 6080 Center Drive, Suite 700, Los Angeles, California 90045, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Jan 12; Vol. 66 (1), pp. 641-656. Date of Electronic Publication: 2022 Dec 22.