Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Khanhky Phamluong"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Chronic use of mTORC1 inhibitors produces undesirable side effects in humans which limit their value for CNS disorders treatment. The authors present a binary drug strategy to protects mTORC1 activity in the periphery and show its potential utility i
Externí odkaz:
https://doaj.org/article/7072a98d7a1d453daff66668b3c58af7
Autor:
Nadege Morisot, Khanhky Phamluong, Yann Ehinger, Anthony L Berger, Jeffrey J Moffat, Dorit Ron
Publikováno v:
eLife, Vol 11 (2022)
Externí odkaz:
https://doaj.org/article/0ad2b404daf34c0cab06223392687035
Autor:
Nadege Morisot, Khanhky Phamluong, Yann Ehinger, Anthony L Berger, Jeffrey J Moffat, Dorit Ron
Publikováno v:
eLife, Vol 8 (2019)
The mechanistic target of rapamycin complex 1 (mTORC1) plays an important role in dendritic translation and in learning and memory. We previously showed that heavy alcohol use activates mTORC1 in the orbitofrontal cortex (OFC) of rodents (Laguesse et
Externí odkaz:
https://doaj.org/article/0b10be1cc7a44522a9c0140cb39f6fbc
Autor:
Mark Z. Chen, Joshua C. Chang, Jose Zavala-Solorio, Lance Kates, Minh Thai, Annie Ogasawara, Xiaobo Bai, Sean Flanagan, Victor Nunez, Khanhky Phamluong, James Ziai, Robert Newman, Søren Warming, Ganesh Kolumam, Junichiro Sonoda
Publikováno v:
Molecular Metabolism, Vol 6, Iss 11, Pp 1454-1467 (2017)
Objective: Fibroblast Growth Factor 21 (FGF21) is a potent stimulator of brown fat thermogenesis that improves insulin sensitivity, ameliorates hepatosteatosis, and induces weight loss by engaging the receptor complex comprised of Fibroblast Growth F
Externí odkaz:
https://doaj.org/article/ce235e57c3334e8584b6bcb64b10b27e
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 21-29 (2017)
Neuronal chloride levels are developmentally regulated. Early in life, high intracellular concentrations support chloride efflux and depolarization at GABAergic synapses. In mouse, intracellular chloride decreases over the first postnatal week in the
Externí odkaz:
https://doaj.org/article/7f6048c262a04de684977cb3bcf300ba
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
The tyrosine kinase Fyn plays an important role in synaptic plasticity, learning, and memory. Here we report that Fyn is activated in response to 15 min D1 receptor (D1R) but not D2 receptor (D2R) stimulation specifically in the dorsomedial striatum
Externí odkaz:
https://doaj.org/article/afeb515710114fa68d72558c688d1950
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160948 (2016)
RACK1 is a scaffolding protein that contributes to the specificity and propagation of several signaling cascades including the cAMP pathway. As such, RACK1 participates in numerous cellular functions ranging from cell migration and morphology to gene
Externí odkaz:
https://doaj.org/article/ea46c06d05db40f2a9f89c0d8335fad7
Autor:
Yan Gong, Eric Bourhis, Cecilia Chiu, Scott Stawicki, Venita I DeAlmeida, Bob Y Liu, Khanhky Phamluong, Tim C Cao, Richard A D Carano, James A Ernst, Mark Solloway, Bonnee Rubinfeld, Rami N Hannoush, Yan Wu, Paul Polakis, Mike Costa
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12682 (2010)
β-Catenin-dependent Wnt signaling is initiated as Wnt binds to both the receptor FZD and coreceptor LRP5/6, which then assembles a multimeric complex at the cytoplasmic membrane face to recruit and inactivate the kinase GSK3. The large number and se
Externí odkaz:
https://doaj.org/article/e5991f379a5147a2b9b70b45b9ce3556
Autor:
J Susie Zoltewicz, Amir M Ashique, Youngshik Choe, Gena Lee, Stacy Taylor, Khanhky Phamluong, Mark Solloway, Andrew S Peterson
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6191 (2009)
Precise regulation of Wnt signaling is important in many contexts, as in development of the vertebrate forebrain, where excessive or ectopic Wnt signaling leads to severe brain defects. Mutation of the widely expressed oto gene causes loss of the ant
Externí odkaz:
https://doaj.org/article/db3c22e679034b0283261f45cc5f29f3
Publikováno v:
Alcohol. 109:99-100