Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Khanh V, Do"'
Autor:
You Jung Kang, Seung Jae Hyeon, Amanda McQuade, Jiwoon Lim, Seung Hyun Baek, Yen N. Diep, Khanh V. Do, Yeji Jeon, Dong‐Gyu Jo, C. Justin Lee, Mathew Blurton‐Jones, Hoon Ryu, Hansang Cho
Publikováno v:
Advanced Science, Vol 11, Iss 20, Pp n/a-n/a (2024)
Abstract Microglial neuroinflammation appears to be neuroprotective in the early pathological stage, yet neurotoxic, which often precedes neurodegeneration in Alzheimer's disease (AD). However, it remains unclear how the microglial activities transit
Externí odkaz:
https://doaj.org/article/5e189f2581fa4244ab1a0031b7cea481
Autor:
Ceren Emre, Luis E. Arroyo-García, Khanh V. Do, Bokkyoo Jun, Makiko Ohshima, Silvia Gómez Alcalde, Megan L. Cothern, Silvia Maioli, Per Nilsson, Erik Hjorth, André Fisahn, Nicolas G. Bazan, Marianne Schultzberg
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Intranasal administration of pro-resolving lipid mediators improves memory deficits and reduce microglial activation in a mouse model for Alzheimer’s disease, suggesting a future therapy.
Externí odkaz:
https://doaj.org/article/19b3984474bb4b898093a4daa1c00e69
Autor:
Kiyoharu J. Miyagishima, Ruchi Sharma, Malika Nimmagadda, Katharina Clore-Gronenborn, Zoya Qureshy, Davide Ortolan, Devika Bose, Mitra Farnoodian, Congxiao Zhang, Andrew Fausey, Yuri V. Sergeev, Mones Abu-Asab, Bokkyoo Jun, Khanh V. Do, Marie-Audrey Kautzman Guerin, Jorgelina Calandria, Aman George, Bin Guan, Qin Wan, Rachel C. Sharp, Catherine Cukras, Paul A. Sieving, Robert B. Hufnagel, Nicolas G. Bazan, Kathleen Boesze-Battaglia, Sheldon Miller, Kapil Bharti
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Miyagishima et al. investigate the pathological mechanisms underlying mutant CTRP5 function in late-onset retinal degeneration (L-ORD). With human iPSC-derived RPE cells, they demonstrate that in L-ORD iRPE, constitutive activation of AMPK disrupts c
Externí odkaz:
https://doaj.org/article/24727da70edd48558b39804aab74c898
Autor:
Ceren Emre, Khanh V. Do, Bokkyoo Jun, Erik Hjorth, Silvia Gómez Alcalde, Marie-Audrey I. Kautzmann, William C. Gordon, Per Nilsson, Nicolas G. Bazan, Marianne Schultzberg
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-26 (2021)
Abstract Sustained brain chronic inflammation in Alzheimer’s disease (AD) includes glial cell activation, an increase in cytokines and chemokines, and lipid mediators (LMs), concomitant with decreased pro-homeostatic mediators. The inflammatory res
Externí odkaz:
https://doaj.org/article/ac96393851724d43b1cdd2767bc6342b
Autor:
Jorgelina M. Calandria, Surjyadipta Bhattacharjee, Nicholas J. Maness, Marie-Audrey I. Kautzmann, Aram Asatryan, William C. Gordon, Khanh V. Do, Bokkyoo Jun, Pranab K. Mukherjee, Nicos A. Petasis, Nicolas G. Bazan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract The pro-homeostatic lipid mediators elovanoids (ELVs) attenuate cell binding and entrance of the SARS-CoV-2 receptor-binding domain (RBD) as well as of the SARS-CoV-2 virus in human primary alveoli cells in culture. We uncovered that very-lo
Externí odkaz:
https://doaj.org/article/23649788b0954184a9a2a7b9024ba830
Autor:
Thang L. Pham, Jiucheng He, Azucena H. Kakazu, Jorgelina Calandria, Khanh V. Do, Robert Nshimiyimana, Ting F. Lam, Nicos A. Petasis, Haydee E. P. Bazan, Nicolas G. Bazan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that causes coronavirus disease 2019 (COVID-19) has resulted in a pandemic affecting the most vulnerable in society, triggering a public health crisis and economic co
Externí odkaz:
https://doaj.org/article/dc09ab38615546c8b5b456b05f0cc312
Autor:
Jiucheng He, Thang L. Pham, Azucena H. Kakazu, Abhilash Ponnath, Khanh V. Do, Haydee E. P. Bazan
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 831 (2023)
Purpose: To investigate the anti-inflammatory and anti-angiogenic effects of the bioactive lipid mediator LXA4 on a rat model of severe corneal alkali injury. Methods: To induce a corneal alkali injury in the right eyes of anesthetized Sprague Dawley
Externí odkaz:
https://doaj.org/article/ec62b926fee047c0831a1ae515fdad2e
Autor:
Aram Asatryan, Jorgelina M. Calandria, Marie-Audrey I. Kautzmann, Bokkyoo Jun, William C. Gordon, Khanh V. Do, Surjyadipta Bhattacharjee, Thang L. Pham, Vicente Bermúdez, Melina Valeria Mateos, Jessica Heap, Nicolas G. Bazan
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Retinal pigment epithelial (RPE) cells sustain photoreceptor integrity, and when this function is disrupted, retinal degenerations ensue. Herein, we characterize a new cell line from human RPE that we termed ABC. These cells remarkably recapitulate h
Externí odkaz:
https://doaj.org/article/dc801f6830e94c9da53e42e67e678744
Autor:
Yannick Das, Daniëlle Swinkels, Sai Kocherlakota, Stefan Vinckier, Frédéric M. Vaz, Eric Wever, Antoine H. C. van Kampen, Bokkyoo Jun, Khanh V. Do, Lieve Moons, Nicolas G. Bazan, Paul P. Van Veldhoven, Myriam Baes
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Patients lacking multifunctional protein 2 (MFP2), the central enzyme of the peroxisomal β-oxidation pathway, develop retinopathy. This pathway is involved in the metabolism of very long chain (VLCFAs) and polyunsaturated (PUFAs) fatty acids, which
Externí odkaz:
https://doaj.org/article/ac08bb97a2c74487a6bf594697e1540a
Autor:
Alfredo Resano, Surjyadipta Bhattacharjee, Miguel Barajas, Khanh V. Do, Roberto Aguado-Jiménez, David Rodríguez, Ricardo Palacios, Nicolás G. Bazán
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 113 (2022)
To contribute to further understanding the cellular and molecular complexities of inflammatory-immune responses in allergic disorders, we have tested the pro-homeostatic elovanoids (ELV) in human nasal epithelial cells (HNEpC) in culture challenged b
Externí odkaz:
https://doaj.org/article/1fcea446c7a64917b9d4cb158f5c191d