Attenuated Salmonella typhimurium htrA mutants cause fatal infections in mice deficient in NADPH oxidase and destroy NADPH oxidase-deficient macrophage monolayers

Autor: Pietro Mastroeni, Julie A. Musson, C E Hormaeche, Graham S, John H. Robinson, M Mutunga, Khan Cm, De Hormaeche Rd

Publikováno v: Vaccine. 22(29-30)

Salmonella live vaccine strains harbouring mutations in htrA , a stress protein gene, display increased susceptibility to oxidative stress in vitro. This is believed to be connected to their reduced virulence, perhaps due to impaired survival inside

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc27a3d36f92579bafee9d0aa037940
https://pubmed.ncbi.nlm.nih.gov/15364466

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Burden or benefit? Effects of providing education about and the option to request additional genomic findings from diagnostic exome sequencing: A randomized controlled trial.

Autor: Rini C; Department of Medical Social Sciences, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA. Electronic address: christine.rini@northwestern.edu., Roche MI; Department of Pediatrics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Lin FC; Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA., Foreman AKM; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Khan CM; U.S. Government Accountability Office, 441G Street NW, Washington, DC 20548, USA., Griesemer I; Department of Health Behavior, University of North Carolina, 135 Dauer Dr., Chapel Hill, NC 27599, USA., Waltz M; Department of Social Medicine, University of North Carolina, Chapel Hill, NC 27599, USA., Lee K; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., O'Daniel JM; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Evans JP; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Berg JS; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Henderson GE; Department of Social Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

Publikováno v: Patient education and counseling [Patient Educ Couns] 2021 Dec; Vol. 104 (12), pp. 2989-2998. Date of Electronic Publication: 2021 Apr 29.

Factors influencing NCGENES research participants' requests for non-medically actionable secondary findings.

Autor: Roche MI; Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA. Myra_Roche@med.unc.edu.; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. Myra_Roche@med.unc.edu.; Center for Genomics and Society, University of North Carolina, Chapel Hill, NC, USA. Myra_Roche@med.unc.edu., Griesemer I; Department of Health Behavior, University of North Carolina, Chapel Hill, NC, USA., Khan CM; Econometrica, Inc., Bethesda, MD, USA., Moore E; Blue Cross and Blue Shield of North Carolina, Durham, NC, USA., Lin FC; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA., O'Daniel JM; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Center for Genomics and Society, University of North Carolina, Chapel Hill, NC, USA., Foreman AKM; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Center for Genomics and Society, University of North Carolina, Chapel Hill, NC, USA., Lee K; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Powell BC; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Center for Genomics and Society, University of North Carolina, Chapel Hill, NC, USA., Berg JS; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Center for Genomics and Society, University of North Carolina, Chapel Hill, NC, USA., Evans JP; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Center for Genomics and Society, University of North Carolina, Chapel Hill, NC, USA.; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Henderson GE; Center for Genomics and Society, University of North Carolina, Chapel Hill, NC, USA.; Department of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Rini C; John Theuer Cancer Center, Hackensack University Medical Center, Hackensack, NJ, USA.

Publikováno v: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2019 May; Vol. 21 (5), pp. 1092-1099. Date of Electronic Publication: 2018 Sep 21.