I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations

Autor: Files, Daniel Clark, Matthay, Michael A, Calfee, Carolyn S, Aggarwal, Neil R, Asare, Adam L, Beitler, Jeremy R, Berger, Paul A, Burnham, Ellen L, Cimino, George, Coleman, Melissa H, Crippa, Alessio, Discacciati, Andrea, Gandotra, Sheetal, Gibbs, Kevin W, Henderson, Paul T, Ittner, Caroline AG, Jauregui, Alejandra, Khan, Kashif T, Koff, Jonathan L, Lang, Julie, LaRose, Mary, Levitt, Joe, Lu, Ruixiao, McKeehan, Jeffrey D, Meyer, Nuala J, Russell, Derek W, Thomas, Karl W, Eklund, Martin, Esserman, Laura J, Liu, Kathleen D, ISPY COVID Adaptive Platform Trial Network, undefined

Publikováno v: BMJ open, vol 12, iss 6

IntroductionThe COVID-19 pandemic brought an urgent need to discover novel effective therapeutics for patients hospitalised with severe COVID-19. The Investigation of Serial studies to Predict Your Therapeutic Response with Imaging And moLecular Anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::d9f768e444a7e77ab41930f2b577a5f9
https://escholarship.org/uc/item/5v07w9r6

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Autor: Perkins, Jessica M.¹, Khan, Kashif T.², Subramanian, S. V.³ svsubram@hsph.harvard.edu

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I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations.

Autor: Files DC; Pulmonary, Critical Care, Allergy and Immunology Division, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA Clark.Files@wakehealth.edu., Matthay MA; University of California San Francisco, San Francisco, California, USA., Calfee CS; University of California San Francisco, San Francisco, California, USA., Aggarwal NR; University of Colorado Denver School of Medicine, Aurora, Colorado, USA., Asare AL; Quantum Leap Healthcare Collaborative, San Francisco, California, USA., Beitler JR; Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University, New York City, New York, USA., Berger PA; Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota, USA., Burnham EL; University of Colorado Denver School of Medicine, Aurora, Colorado, USA., Cimino G; Quantum Leap Healthcare Collaborative, Fremont, California, USA., Coleman MH; University of California San Francisco, San Francisco, California, USA., Crippa A; Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Stockholm, Sweden., Discacciati A; Karolinska Institute, Stockholm, Stockholm, Sweden., Gandotra S; Pulmonary, Allergy, Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Gibbs KW; Department of Medicine, Section of Pulmonary, Critical Care, Allergy and Immunologic Disease, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Henderson PT; Quantum Leap Healthcare Collaborative, San Francisco, California, USA., Ittner CAG; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Jauregui A; University of California San Francisco, San Francisco, California, USA., Khan KT; University of Southern California, Los Angeles, California, USA., Koff JL; Yale School of Medicine, New Haven, Connecticut, USA., Lang J; University of Southern California, Los Angeles, California, USA., LaRose M; Department of Medicine, Section of Pulmonary, Critical Care, Allergy and Immunologic Disease, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Levitt J; Stanford University, Stanford, California, USA., Lu R; Quantum Leap Healthcare Collaborative, Fremont, California, USA., McKeehan JD; University of Colorado, Denver, Colorado, USA., Meyer NJ; Medicine, Division of Pulmonary, Allergy, & Critical Care Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Russell DW; Division of Pulmonary, Allergy, & Critical Care Medicine, The University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA., Thomas KW; Department of Medicine, Section of Pulmonary, Critical Care, Allergy and Immunologic Disease, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Eklund M; Karolinska Institutet, Stockholm, Sweden., Esserman LJ; University of California San Francisco, San Francisco, California, USA., Liu KD; Nephrology, University of California San Francisco, San Francisco, California, USA.

Publikováno v: BMJ open [BMJ Open] 2022 Jun 06; Vol. 12 (6), pp. e060664. Date of Electronic Publication: 2022 Jun 06.