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Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment.

Autor: Widman AJ; New York Genome Center, New York, NY, USA. widmana@mskcc.org.; Memorial Sloan Kettering Cancer Center, New York, NY, USA. widmana@mskcc.org., Shah M; New York Genome Center, New York, NY, USA., Frydendahl A; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Halmos D; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Khamnei CC; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Øgaard N; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Rajagopalan S; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Arora A; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Deshpande A; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Hooper WF; New York Genome Center, New York, NY, USA., Quentin J; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Bass J; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Zhang M; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Langanay T; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Andersen L; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Steinsnyder Z; New York Genome Center, New York, NY, USA., Liao W; New York Genome Center, New York, NY, USA., Rasmussen MH; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Henriksen TV; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Jensen SØ; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Nors J; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Therkildsen C; Gastro Unit, Copenhagen University Hospital, Amager - Hvidovre Hospital, Hvidovre, Denmark., Sotelo J; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Brand R; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Schiffman JS; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Shah RH; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Cheng AP; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Maher C; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA., Spain L; Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK.; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London, UK., Krause K; Mass General Cancer Center, Massachusetts General Hospital, Boston, MA, USA., Frederick DT; Mass General Cancer Center, Massachusetts General Hospital, Boston, MA, USA., den Brok W; Department of Medical Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Lohrisch C; Department of Medical Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Shenkier T; Department of Medical Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Simmons C; Department of Medical Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Villa D; Department of Medical Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Mungall AJ; Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada., Moore R; Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada., Zaikova E; Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Cerda V; Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Kong E; Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Lai D; Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Malbari MS; Weill Cornell Medicine, New York, NY, USA., Marton M; New York Genome Center, New York, NY, USA., Manaa D; New York Genome Center, New York, NY, USA., Winterkorn L; New York Genome Center, New York, NY, USA., Gelmon K; Department of Medical Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada., Callahan MK; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Boland G; Mass General Cancer Center, Massachusetts General Hospital, Boston, MA, USA., Potenski C; New York Genome Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Wolchok JD; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Saxena A; Weill Cornell Medicine, New York, NY, USA., Turajlic S; Cancer Dynamics Laboratory, The Francis Crick Institute, London, UK.; Renal and Skin Unit, The Royal Marsden NHS Foundation Trust, London, UK., Imielinski M; New York Genome Center, New York, NY, USA.; Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY, USA., Berger MF; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Aparicio S; Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Altorki NK; Weill Cornell Medicine, New York, NY, USA., Postow MA; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medicine, New York, NY, USA., Robine N; New York Genome Center, New York, NY, USA., Andersen CL; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Landau DA; New York Genome Center, New York, NY, USA. dlandau@nygenome.org.; Weill Cornell Medicine, New York, NY, USA. dlandau@nygenome.org.

Publikováno v: Nature medicine [Nat Med] 2024 Jun; Vol. 30 (6), pp. 1655-1666. Date of Electronic Publication: 2024 Jun 14.