Anacardic Acids from Knema hookeriana as Modulators of Bcl-xL/Bak and Mcl-1/Bid Interactions

Autor: Nicolas Birlirakis, Marc Litaudon, Jérôme Bignon, Vincent Dumontet, Eric Guittet, Gwladys Rivière, Charlotte Gény, Khaljah Awang, Fanny Roussi

Publikováno v: Journal of Natural Products
Journal of Natural Products, 2016, 79 (4), pp.838-844. ⟨10.1021/acs.jnatprod.5b00915⟩
Journal of Natural Products, American Chemical Society, 2016, 79 (4), pp.838-844. ⟨10.1021/acs.jnatprod.5b00915⟩

International audience; Proteins of the Bcl-2 family are key targets in anticancer drug discovery. Disrupting the interaction between anti and pro-apoptotic members of this protein family was the approach chosen in this study to restore apoptosis. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205a4bc45549d53af4f9ea2e44ab3a8b
https://doi.org/10.1021/acs.jnatprod.5b00915