Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila

Autor: Lydie Couturier, Khalil Mazouni, Francis Corson, François Schweisguth

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

The patterning of sensory bristles on the dorsal thorax of flies is regulated by two transcription factor families but the dynamics of this regulation is unclear. Here, the authors visualize seven E(spl)-HLH proteins, showing their regulated expressi

Externí odkaz: https://doaj.org/article/b1e2fcacebd2420186e6c4bfdc70b544

Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila

Autor: Gantas Perez-Mockus, Khalil Mazouni, Vanessa Roca, Giulia Corradi, Vito Conte, François Schweisguth

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

In the Drosophila embryo, increased cortical contractility in ventral cells causes furrow formation and gastrulation. Here, the authors show that contractility is regulated by Neuralized (an E3 ubiquitin ligase) in ventral cells, and that inhibiting

Externí odkaz: https://doaj.org/article/24d2c0ca2e764313a9b352417c36d5de

Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila

Autor: Khalil Mazouni, Francis Corson, François Schweisguth, Lydie Couturier

Publikováno v: Nature Communications
Nature Communications, 2019, 10 (1), pp.3486. ⟨10.1038/s41467-019-11477-2⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.3486. ⟨10.1038/s41467-019-11477-2⟩
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

The stereotyped arrangement of sensory bristles on the adult fly thorax arises from a self-organized process, in which inhibitory Notch signaling both delimits proneural stripes and singles out sensory organ precursor cells (SOPs). A dynamic balance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feaddd0cd8db454e4d26d11b3d1655b7
https://hal-pasteur.archives-ouvertes.fr/pasteur-02348104/document

Self-organized Notch dynamics generate stereotyped sensory organ patterns in Drosophila

Autor: Lydie Couturier, Khalil Mazouni, François Schweisguth, Francis Corson, Hervé Rouault

Publikováno v: Science
Science, American Association for the Advancement of Science, 2017, 356 (6337), pp.eaai7407. ⟨10.1126/science.aai7407⟩
Science, 2017, 356 (6337), pp.eaai7407. ⟨10.1126/science.aai7407⟩

International audience; INTRODUCTION: Spatial patterning in developing multicellular organisms relies on positional cues and cell-cell interactions. Stereotyped sensory organ arrangements in Drosophila are commonly attributed to a prepattern that def

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41a12159cf0d21f16379bb11689d5cc
https://hal.sorbonne-universite.fr/hal-01543700/file/Corson_2017_Self-organized.pdf

Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling

Autor: Ryan B. MacDonald, Stefan Thor, Caroline Bivik, François Schweisguth, Khalil Mazouni, Erika Gunnar

Publikováno v: PLoS Genetics
PLoS Genetics, Public Library of Science, 2016, 12 (4), pp.e1005984. 〈10.1371/journal.pgen.1005984〉
PLoS Genetics, 2016, 12 (4), pp.e1005984. ⟨10.1371/journal.pgen.1005984⟩
PLoS Genetics, Public Library of Science, 2016, 12 (4), pp.e1005984. ⟨10.1371/journal.pgen.1005984⟩
PLoS Genetics, Vol 12, Iss 4, p e1005984 (2016)

The Notch pathway controls proliferation during development and in adulthood, and is frequently affected in many disorders. However, the genetic sensitivity and multi-layered transcriptional properties of the Notch pathway has made its molecular deco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366ad3e440ed3574d19536ebae79ba91
http://europepmc.org/articles/PMC4829154