miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers

Autor: Khalil Arar, Christina Laurini, Michèle Sabbah, Laurent Vallar, Michèle Moes, Charles-Henri Lecellier, Evelyne Friederich, A. Le Bechec, Guillaume Vetter, Anne Saumet, Charles Theillet

Publikováno v: Oncogene
Oncogene, 2010, 29 (31), pp.4436-48. ⟨10.1038/onc.2010.181⟩
Oncogene, Nature Publishing Group, 2010, 29 (31), pp.4436-48. ⟨10.1038/onc.2010.181⟩
Oncogene, 35(5), 670. Nature Publishing Group (2016).
Oncogene, Nature Publishing Group, 2010, 29 (31), pp.4436-48. 〈10.1038/onc.2010.181〉

4; International audience; Epithelial to mesenchymal transition (EMT) is a key step toward metastasis. MCF7 breast cancer cells conditionally expressing the EMT master regulator SNAI1 were used to identify early expressed microRNAs (miRNAs) and their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c243099e3660956d908774a0b2378d
https://doi.org/10.1038/onc.2010.181

Transcriptional repression of microRNA genes by PML-RARA increases expression of key cancer proteins in acute promyelocytic leukemia

Autor: Bernard Mari, Elodie Portales-Casamar, Bruno Cassinat, Evelyne Friederich, Christine Chomienne, Khalil Arar, Pascal Barbry, Thomas Maurin, Anne Saumet, Manuella Bouttier, Laurent Vallar, Guillaume Vetter, Charles-Henri Lecellier, Wyeth W. Wasserman

Publikováno v: Blood
Blood, American Society of Hematology, 2009, 113 (2), pp.412-21. ⟨10.1182/blood-2008-05-158139⟩
Blood, American Society of Hematology, 2009, 113 (2), pp.412-21. 〈10.1182/blood-2008-05-158139〉

Micro(mi)RNAs are small noncoding RNAs that orchestrate many key aspects of cell physiology and their deregulation is often linked to distinct diseases including cancer. Here, we studied the contribution of miRNAs in a well-characterized human myeloi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e10ca83a269cddf272d030a7c52e468
https://doi.org/10.1182/blood-2008-05-158139

RecA-mediated strand invasion of DNA by oligonucleotides substituted with 2-aminoadenine and 2-thiothymine

Autor: Khalil Arar, Ya-Ming Hou, Howard Gamper, Georges Lahoud

Publikováno v: Nucleic Acids Research

Sequence-specific recognition of DNA is a critical step in gene targeting. Here we describe unique oligonucleotide (ON) hybrids that can stably pair to both strands of a linear DNA target in a RecA-dependent reaction with ATP or ATPgammaS. One strand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be21267e24f5494e99af740d0f17aa2
http://europepmc.org/articles/PMC2588519

Inhibiting Gene Expression with Locked Nucleic Acids (LNAs) That Target Chromosomal DNA

Autor: David R. Corey, Rosalyn Ram, Brett P. Monia, Sylvie Gabillet, Khalil Arar, Randall L. Beane

Publikováno v: Biochemistry. 46:7572-7580

Oligonucleotides containing locked nucleic acid bases (LNAs) have increased affinity for complementary DNA sequences. We hypothesized that enhanced affinity might allow LNAs to recognize chromosomal DNA inside human cells and inhibit gene expression.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e1b424bdd41887209a808c620f6a4b
https://doi.org/10.1021/bi700227g

NMR solution structures of LNA (locked nucleic acid) modified quadruplexes

Autor: Jakob T. Nielsen, Michael Nebeling Petersen, Khalil Arar

Publikováno v: Nucleic Acids Research

We have determined the NMR solution structures of the quadruplexes formed by d(TGLGLT) and d(TL4T), where L denotes LNA (locked nucleic acid) modified G-residues. Both structures are tetrameric, parallel and right-handed and the native global fold of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196720ebcda794f4f3a4a32a48196c77
https://doi.org/10.1093/nar/gkl144