Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Khalil Abou‐El‐Ardat"'
S105: CLONAL DIFFERENTIATION TRAJECTORIES OF ADULT ACUTE LYMPHOBLASTIC LEUKEMIA AT SINGLE CELL LEVEL
Autor:
Alec Geßner, Adrien Jolly, Tjeerd Sijmonsma, Weijia Yu, Khalil Abou-El-Ardat, Manuel Kaulich, Stefan Guenther, Fabian Lang, Florian Buettner, Michael Rieger
Publikováno v:
HemaSphere, Vol 7, p e123932c (2023)
Externí odkaz:
https://doaj.org/article/4e51e943f04b4f57ba4981f2619dc9b4
Autor:
Katharina C. Kiefer, Sebastian Cremer, Evangelia Pardali, Birgit Assmus, Khalil Abou‐El‐Ardat, Klara Kirschbaum, Lena Dorsheimer, Tina Rasper, Alexander Berkowitsch, Hubert Serve, Stefanie Dimmeler, Andreas M. Zeiher, Michael A. Rieger
Publikováno v:
ESC Heart Failure, Vol 8, Iss 3, Pp 1873-1884 (2021)
Abstract Aims Somatic mutations in haematopoietic stem cells can lead to the clonal expansion of mutated blood cells, known as clonal haematopoiesis (CH). Mutations in the most prevalent driver genes DNMT3A and TET2 with a variant allele frequency (V
Externí odkaz:
https://doaj.org/article/54d19ff862694ff0856fac32d8a2abdc
Autor:
Lena Dorsheimer, Birgit Assmus, Tina Rasper, Christina A. Ortmann, Khalil Abou-El-Ardat, Katharina C. Kiefer, Jedrzej Hoffmann, Florian Seeger, Halvard Bonig, Stefanie Dimmeler, Andreas M. Zeiher, Michael A. Rieger
Publikováno v:
Haematologica, Vol 105, Iss 7 (2020)
Externí odkaz:
https://doaj.org/article/29ae9a1851484539aef3bf97e9d03c2d
Autor:
Christina A. Ortmann, Lena Dorsheimer, Khalil Abou-El-Ardat, Jennifer Hoffrichter, Birgit Assmus, Halvard Bonig, Anica Scholz, Heike Pfeifer, Hans Martin, Tobias Schmid, Bernhard Brüne, Sebastian Scheich, Björn Steffen, Julia Riemann, Stella Hermann, Alexandra Dukat, Gesine Bug, Christian H. Brandts, Sebastian Wagner, Hubert Serve, Michael A. Rieger
Publikováno v:
Cell Reports, Vol 27, Iss 7, Pp 2022-2028.e3 (2019)
Summary: Clonal hematopoiesis of indeterminate potential (CHIP) is caused by recurrent somatic mutations leading to clonal blood cell expansion. However, direct evidence of the fitness of CHIP-mutated human hematopoietic stem cells (HSCs) in blood re
Externí odkaz:
https://doaj.org/article/c59b55a4abea4891a6ce2eedd4dfb75b
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100295 (2014)
Changes in gene expression programs play a central role in cancer. Chromosomal aberrations such as deletions, duplications and translocations of DNA segments can lead to highly significant positive correlations of gene expression levels of neighborin
Externí odkaz:
https://doaj.org/article/dfd422d0c8844cbc8854f9b5f8bc0dde
Autor:
Sophie Eisenreich, Khalil Abou-El-Ardat, Karol Szafranski, Jaime A Campos Valenzuela, Andreas Rump, Janice M Nigro, Rolf Bjerkvig, Eva-Maria Gerlach, Karl Hackmann, Evelin Schröck, Dietmar Krex, Lars Kaderali, Gabriele Schackert, Matthias Platzer, Barbara Klink
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e76623 (2013)
Oligodendroglial tumors form a distinct subgroup of gliomas, characterized by a better response to treatment and prolonged overall survival. Most oligodendrogliomas and also some oligoastrocytomas are characterized by a unique and typical unbalanced
Externí odkaz:
https://doaj.org/article/801c70ba21a348528b99e6c36c4f4533
Autor:
Can Canbulat, Thomas Oellerich, Susanne Wingert, Mike Heilemann, Marina S. Dietz, Katharina Holzer, Elsie Oppermann, Ilaria Lunger, Michael A. Rieger, Hans-Michael Kvasnicka, Patrizia Malkomes, Nadine Haetscher, Claudia Catapano, Weijia Yu, Wolf O. Bechstein, Hubert Serve, Sabrina Bothur, Khalil Abou-El-Ardat, Stefan Günther, Frank Schnütgen
Publikováno v:
Oncogene
Despite a high clinical need for the treatment of colorectal carcinoma (CRC) as the second leading cause of cancer-related deaths, targeted therapies are still limited. The multifunctional enzyme Transglutaminase 2 (TGM2), which harbors transamidatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd0996e05891e2ce27a0196f7b69c09
https://doi.org/10.1038/s41388-021-01847-w
https://doi.org/10.1038/s41388-021-01847-w
Autor:
Brandts, Fatima Baker, Ibrahim H. Polat, Khalil Abou-El-Ardat, Islam Alshamleh, Marlyn Thoelken, Daniel Hymon, Andrea Gubas, Sebastian E. Koschade, Jonas B. Vischedyk, Manuel Kaulich, Harald Schwalbe, Shabnam Shaid, Christian H.
Publikováno v:
Cancers; Volume 13; Issue 23; Pages: 6142
Autophagy is an important survival mechanism that allows recycling of nutrients and removal of damaged organelles and has been shown to contribute to the proliferation of acute myeloid leukemia (AML) cells. However, little is known about the mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::076a2c764936ef166e630216533be8b9
Autor:
Fatima Baker, Ibrahim H. Polat, Khalil Abou-El-Ardat, Islam Alshamleh, Marlyn Thoelken, Daniel Hymon, Andrea Gubas, Sebastian E. Koschade, Jonas B. Vischedyk, Manuel Kaulich, Harald Schwalbe, Shabnam Shaid, Christian H. Brandts
Publikováno v:
Cancers
Cancers, Vol 13, Iss 6142, p 6142 (2021)
Cancers, Vol 13, Iss 6142, p 6142 (2021)
Simple Summary The importance of autophagy in leukemia progression and survival has been studied previously. However, little is known about the development of resistance mechanisms to autophagy inhibition in leukemia. Here, we present data on the mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8311a5854e8796698445780776050256
http://europepmc.org/articles/PMC8657081
http://europepmc.org/articles/PMC8657081
Autor:
Alec Geßner, Tjeerd Sijmonsma, Yu WeiJia, Khalil Abou-El-Ardat, Manuel Kaulich, Stefan Günther, Fabian Lang, Florian Büttner, Michael Rieger
Publikováno v:
Experimental Hematology. 111:S88-S89
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1844b01c050858ee3c02ac53eda4ed3
https://doi.org/10.1016/j.exphem.2022.07.144
https://doi.org/10.1016/j.exphem.2022.07.144