Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Khalil, Helou"'
Autor:
Peter Larsson, Maria Cristina De Rosa, Benedetta Righino, Maxim Olsson, Bogdan Iulius Florea, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou, Toshima Z. Parris
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Computational pharmacogenomics can potentially identify new indications for already approved drugs and pinpoint compounds with similar mechanism-of-action. Here, we used an integrated drug repositioning approach based on transcriptomics data
Externí odkaz:
https://doaj.org/article/1b44d542d84c498ebb49958dfa4cacc1
Autor:
Peter Larsson, Maxim Olsson, Sithumini Sarathchandra, Anna Fäldt Beding, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou, Toshima Z. Parris
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Repurposing of FDA-approved drugs is a quick and cost-effective alternative to de novo drug development. Here, we identify genes involved in bortezomib sensitivity, predict cancer types that may benefit from treatment with bortezomib, and ev
Externí odkaz:
https://doaj.org/article/cb8556dc4f164843a07201a962a40d0f
Autor:
Malin Druid, Emman Shubbar, Johan Spetz, Toshima Z. Parris, Britta Langen, Charlotte Ytterbrink, Evelin Berger, Khalil Helou, Eva Forssell-Aronsson
Publikováno v:
Radiation, Vol 4, Iss 2, Pp 149-166 (2024)
The physiological process of iodine uptake in the thyroid is used for 131I treatment of thyroid diseases. Children are more sensitive to radiation compared to adults and may react differently to 131I exposure. The aims of this study were to evaluate
Externí odkaz:
https://doaj.org/article/c8da68c9e399443299056ea3d7f2c5d3
Autor:
Ghassan M. Saed, Nicole M. Fletcher, Harvey Sharma, Axel Stenmark Tullberg, Ella Ittner, Toshima Z. Parris, Daniella Pettersson, Anikó Kovács, Elisabeth Werner Rönnerman, Pernilla Dahm-Kähler, Anna Portela, Pamela D. Garzone, Robert Morris, Khalil Helou
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 3, Pp 200864- (2024)
Lemur tail kinase 3 (LMTK3) belongs to a family of tyrosine kinases that are known to correlate with tumor grade and patient survival in some cancers. Here, we validated LMTK3 as a specific target and a prognostic biomarker in ovarian cancer (OC). In
Externí odkaz:
https://doaj.org/article/c738a39ca4d94f82901e0ffdd34b58cd
Autor:
Manuel Luna Santamaría, Daniel Andersson, Toshima Z. Parris, Khalil Helou, Tobias Österlund, Anders Ståhlberg
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Mutation analysis is typically performed at the DNA level since most technical approaches are developed for DNA analysis. However, some applications, like transcriptional mutagenesis, RNA editing and gene expression analysis, require RNA ana
Externí odkaz:
https://doaj.org/article/0e4df2b9e55c46e09023d14dc260def7
Autor:
Peter Larsson, Daniella Pettersson, Maxim Olsson, Sithumini Sarathchandra, Alexandra Abramsson, Henrik Zetterberg, Ella Ittner, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou, Toshima Z. Parris
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Triple-negative breast cancer (TNBC) is associated with poor prognosis and limited treatment options due to the lack of important receptors (estrogen receptor [ER], progesterone receptor [PR], and human epidermal growth factor receptor 2 [HE
Externí odkaz:
https://doaj.org/article/e80a4b8167f54e5caf8924d9786d6e04
Autor:
Maria Carmen Leiva, Anna Gustafsson, Elena Garre, Anders Ståhlberg, Anikó Kovács, Khalil Helou, Göran Landberg
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Background The tumor microenvironment clearly influences cancer progressing properties but less is known about how individual cancer microenvironments potentially moderate cancer treatment effects. By cultivating and treating cancer cell lin
Externí odkaz:
https://doaj.org/article/41fdf1298b28424aad7fdf8966ef5a49
Autor:
Nishte Rassol, Charlotte Andersson, Daniella Pettersson, Amin Al-Awar, Emman Shubbar, Anikó Kovács, Bo Åkerström, Magnus Gram, Khalil Helou, Eva Forssell-Aronsson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Recombinant α1-microglobulin (A1M) is a proposed radioprotector during 177Lu-octreotate therapy of neuroendocrine tumors (NETs). To ensure a maintained therapeutic effect, we previously demonstrated that A1M does not affect the 177Lu-octreo
Externí odkaz:
https://doaj.org/article/d08f21ecdcde4e42a86b298d4798120c
Autor:
Peter Larsson, Daniella Pettersson, Hanna Engqvist, Elisabeth Werner Rönnerman, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou, Toshima Z. Parris
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-19 (2022)
Abstract Background The human proteasome gene family (PSM) consists of 49 genes that play a crucial role in cancer proteostasis. However, little is known about the effect of PSM gene expression and genetic alterations on clinical outcome in different
Externí odkaz:
https://doaj.org/article/0b6d28bf99c64421a36b298b87f62f51
Autor:
Britta Langen, Egor Vorontsov, Johan Spetz, John Swanpalmer, Carina Sihlbom, Khalil Helou, Eva Forssell-Aronsson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Molecular biomarkers of ionizing radiation (IR) exposure are a promising new tool in various disciplines: they can give necessary information for adaptive treatment planning in cancer radiotherapy, enable risk projection for radiation-induce
Externí odkaz:
https://doaj.org/article/777b4730578e477f87548dc16c4e15bd