Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Khalid W. Kalim"'
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
RhoA of the Rho GTPase family is prenylated at its C-terminus. Prenylation of RhoA has been shown to control T helper 17 (Th17) cell-mediated colitis. By characterizing T cell-specific RhoA conditional knockout mice, we have recently shown that RhoA
Externí odkaz:
https://doaj.org/article/7361ff77742f4a8e83b141d2bb18f362
Autor:
Phuong Nguyen, Jayati Chakrabarti, Yuan Li, Khalid W. Kalim, Mengnan Zhang, Lin Zhang, Yi Zheng, Fukun Guo
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Multiple myeloma (MM) drug resistance highlights a need for alternative therapeutic strategies. In this study, we show that CASIN, a selective inhibitor of cell division cycle 42 (Cdc42) GTPase, inhibited proliferation and survival of melphalan/borte
Externí odkaz:
https://doaj.org/article/0fe025c175a54a60ba066af2954d163e
Autor:
Khalid W Kalim, Jun-Qi Yang, Mark Wunderlich, Vishnu Modur, Phuong Nguyen, Yuan Li, Ting Wen, Ashley Kuenzi Davis, Ravinder Verma, Qing Richard Lu, Anil G Jegga, Yi Zheng, Fukun Guo
Publikováno v:
Journal for immunotherapy of cancer. 10(11)
BackgroundCancer immunotherapy has taken center stage in cancer treatment. However, the current immunotherapies only benefit a small proportion of patients with cancer, necessitating better understanding of the mechanisms of tumor immune evasion and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc5df94cdb259e4986dd2fa72819b33
https://pubmed.ncbi.nlm.nih.gov/36427906
https://pubmed.ncbi.nlm.nih.gov/36427906
Publikováno v:
The Journal of Immunology. 200:2313-2326
A balance between Th17 cells and regulatory T cells (Tregs) is important for host immunity and immune tolerance. The underlying molecular mechanisms remain poorly understood. Here we have identified Cdc42 as a central regulator of Th17/Treg balance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b562623825c52ca5d1d229eed4678b4c
https://doi.org/10.4049/jimmunol.1601765
https://doi.org/10.4049/jimmunol.1601765
Autor:
Eric P. Dixon, Vikas Tahiliani, Matthew M. Seavey, Anh M. Trinh, Rahul R. Jasuja, Khalid W. Kalim, Jayalakshmi Miriyala, Jeff Hutchins, Patrick Dillon, Abra N. Chaney
Publikováno v:
Cancer Research. 81:604-604
Tumor cells evolve multiple mechanisms to escape immune surveillance, one of which is to establish a tolerogenic microenvironment by recruiting immune suppressive cell types such as regulatory T cells (Tregs). Tumor Necrosis Factor Receptor Super Fam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42be20aa188af773a7869c847eed6e92
https://doi.org/10.1158/1538-7445.am2021-604
https://doi.org/10.1158/1538-7445.am2021-604
Publikováno v:
J Leukoc Biol
Asthma is a heterogeneous chronic airway inflammation in which Th2 and Th17 cells are key players in its pathogenesis. We have reported that RhoA of Rho GTPases orchestrated glycolysis for Th2 cell differentiation and allergic airway inflammation by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f777ab04b3d863d6d78bed95e955e8
https://pubmed.ncbi.nlm.nih.gov/31260596
https://pubmed.ncbi.nlm.nih.gov/31260596
Autor:
Nathan Salomonis, Ting Wen, Fukun Guo, Khalid W. Kalim, Brandy Ruff, Xin Duan, John Kroner, Li Zhang, Gurjit K. Khurana Hershey, Yuan Li, Jun-Qi Yang, Phuong Nguyen, Yi Zheng, Mark Rochman
Background Asthma is an allergic airway inflammation-driven disease that affects more than 300 million people world-wide. Targeted therapies for asthma are largely lacking. Although asthma symptoms can be prevented from worsening, asthma development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043ec64c2745911295837e8d8b4e4c8f
https://europepmc.org/articles/PMC6310654/
https://europepmc.org/articles/PMC6310654/
Autor:
Benjamin Mizukawa, Yi Zheng, Diamantis G. Konstantinidis, Jun-Qi Yang, Richard A. Lang, Theodosia A. Kalfa, Shuangmin Zhang, Fukun Guo, Khalid W. Kalim
Publikováno v:
The Journal of Immunology. 193:5973-5982
Thymocyte development is regulated by complex signaling pathways. How these signaling cascades are coordinated remains elusive. RhoA of the Rho family small GTPases plays an important role in actin cytoskeleton organization, cell adhesion, migration,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba5039e8d9841b6f83856c1fd22d3f2
https://doi.org/10.4049/jimmunol.1400839
https://doi.org/10.4049/jimmunol.1400839
Autor:
Laura Bauer, Franziska Fuhrmann, Andreas Radbruch, Fridolin Gross, Khalid W. Kalim, Hanspeter Herzel, Tobias Scheel, Timo Lischke, Andreas Hutloff, Ria Baumgrass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9cd1d11d58dd0c7047953b8ab25dbea
https://doi.org/10.7554/elife.20616.017
https://doi.org/10.7554/elife.20616.017
Autor:
Hanspeter Herzel, Tobias Scheel, Ria Baumgrass, Timo Lischke, Franziska Fuhrmann, Fridolin Gross, Andreas Hutloff, Laura Bauer, Khalid W. Kalim, Andreas Radbruch
Publikováno v:
eLife, Vol 5 (2016)
eLife
eLife
The IL-2/IL-2Ralpha (CD25) axis is of central importance for the interplay of effector and regulatory T cells. Nevertheless, the question how different antigen loads are translated into appropriate IL-2 production to ensure adequate responses against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8d871d81f526df9ddc693333f80ebc
https://elifesciences.org/articles/20616
https://elifesciences.org/articles/20616