Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Khalid Salaita"'
Autor:
Kaitao Li, Paul Cardenas-Lizana, Jintian Lyu, Anna V. Kellner, Menglan Li, Peiwen Cong, Valencia E. Watson, Zhou Yuan, Eunseon Ahn, Larissa Doudy, Zhenhai Li, Khalid Salaita, Rafi Ahmed, Cheng Zhu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Despite the success of PD-1 blockade in cancer therapy, how PD-1 initiates signaling remains unclear. Soluble PD-L1 is found in patient sera and can bind PD-1 but fails to suppress T cell function. Here, we show that PD-1 function is reduced
Externí odkaz:
https://doaj.org/article/202742e2c87c4895aea226594428ba31
Autor:
Selma Piranej, Luona Zhang, Alisina Bazrafshan, Mariana Marin, Gregory B. Melikian, Khalid Salaita
Publikováno v:
ACS Central Science, Vol 10, Iss 7, Pp 1332-1347 (2024)
Externí odkaz:
https://doaj.org/article/e386a192ddcc482cadd8e4d7d2c43ac8
Autor:
Parvin Forghani, Aysha Rashid, Lawrence C. Armand, David Wolfson, Rui Liu, Hee Cheol Cho, Joshua T. Maxwell, Hanjoong Jo, Khalid Salaita, Chunhui Xu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) possess tremendous potential for basic research and translational application. However, these cells structurally and functionally resemble fetal cardiomyocytes, whi
Externí odkaz:
https://doaj.org/article/3296641540fe46919673509caadadabf
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The mechanical dysregulation of cells is associated with a number of disease states, that spans from fibrosis to tumorigenesis. Hence, it is highly desirable to develop strategies to deliver drugs based on the “mechanical phenotype” of a
Externí odkaz:
https://doaj.org/article/86bb45c98bba47829374e87d0bf35c63
Autor:
Mitchell S. Wang, Yuesong Hu, Elisa E. Sanchez, Xihe Xie, Nathan H. Roy, Miguel de Jesus, Benjamin Y. Winer, Elizabeth A. Zale, Weiyang Jin, Chirag Sachar, Joanne H. Lee, Yeonsun Hong, Minsoo Kim, Lance C. Kam, Khalid Salaita, Morgan Huse
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/69988d359ee64fb2a6052a6711250dd3
Autor:
Mitchell S. Wang, Yuesong Hu, Elisa E. Sanchez, Xihe Xie, Nathan H. Roy, Miguel de Jesus, Benjamin Y. Winer, Elizabeth A. Zale, Weiyang Jin, Chirag Sachar, Joanne H. Lee, Yeonsun Hong, Minsoo Kim, Lance C. Kam, Khalid Salaita, Morgan Huse
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Cytotoxic lymphocytes fight pathogens and cancer by forming immune synapses with infected or transformed target cells and then secreting cytotoxic perforin and granzyme into the synaptic space, with potent and specific killing achieved by th
Externí odkaz:
https://doaj.org/article/714e2c54408043c7a7f481a9f4492c05
Autor:
Tomasz J. Nawara, Yancey D. Williams, Tejeshwar C. Rao, Yuesong Hu, Elizabeth Sztul, Khalid Salaita, Alexa L. Mattheyses
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Despite decades of research, the dynamics of clathrin-coated vesicle formation is ambiguous. Here, authors use STAR microscopy to quantify the nanoscale dynamics of vesicle formation, supporting the flexible model of clathrin-mediated endocytosis.
Externí odkaz:
https://doaj.org/article/13c8ab52b5f2464c8a2f26545a51deb6
Autor:
Aaron Blanchard, J. Dale Combs, Joshua M. Brockman, Anna V. Kellner, Roxanne Glazier, Hanquan Su, Rachel L. Bender, Alisina S. Bazrafshan, Wenchun Chen, M. Edward Quach, Renhao Li, Alexa L. Mattheyses, Khalid Salaita
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The authors have recently developed molecular force microscopy (MFM) which uses fluorescence polarisation to measure cell-surface receptor force orientation. Here they show that structured illumination microscopes, which inherently use fluorescence p
Externí odkaz:
https://doaj.org/article/eb25c5882deb4c9a8bdcaa77f44d63b7
Autor:
Tina Wiegand, Marta Fratini, Felix Frey, Klaus Yserentant, Yang Liu, Eva Weber, Kornelia Galior, Julia Ohmes, Felix Braun, Dirk-Peter Herten, Steeve Boulant, Ulrich S. Schwarz, Khalid Salaita, E. Ada Cavalcanti-Adam, Joachim P. Spatz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Many intracellular pathogens mimic extracellular matrix motifs to specifically interact with the host membrane which may influences virus particle uptake. Here authors use single molecule tension sensors to reveal the minimal forces exerted on single
Externí odkaz:
https://doaj.org/article/5db88d0c54e4431a923d087d974d5bcb
Autor:
Parvin Forghani, Aysha Rashid, Fangxu Sun, Rui Liu, Dong Li, Megan R. Lee, Hyun Hwang, Joshua T. Maxwell, Anant Mandawat, Ronghu Wu, Khalid Salaita, Chunhui Xu
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 24 (2021)
Background Anticancer therapies have significantly improved patient outcomes; however, cardiac side effects from cancer therapies remain a significant challenge. Cardiotoxicity following treatment with proteasome inhibitors such as carfilzomib is kno
Externí odkaz:
https://doaj.org/article/404f0cd859ca4ac0895158d80525b5f3