Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Khalid S. Mohammad"'
Autor:
Trupti Trivedi, Gabriel M. Pagnotti, Sukanya Suresh, Yun She, Sreemala Murthy, Jade Martinez, Carmella-Evans Molina, Khalid S. Mohammad, Theresa A. Guise
Publikováno v:
Journal of Bone Oncology, Vol 45, Iss , Pp 100587- (2024)
Externí odkaz:
https://doaj.org/article/d0b7f28991ed4eca8e5052c0099eb7aa
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8163 (2024)
Bone metastases, a common and debilitating consequence of advanced cancers, involve a complex interplay between malignant cells and the bone microenvironment. Central to this interaction are interleukins (ILs), a group of cytokines with critical role
Externí odkaz:
https://doaj.org/article/7385c8a687c74e30923f14d10f7de389
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 1075 (2024)
The phenomenon of bone metastases presents a significant challenge within the context of advanced cancer treatments, particularly pertaining to breast, prostate, and lung cancers. These metastatic occurrences stem from the dissemination of cancerous
Externí odkaz:
https://doaj.org/article/29f79f43724f46f7aec9461081abcadb
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2846 (2024)
The treatment of patients with advanced cancer poses clinical problems due to the complications that arise as the disease progresses. Bone metastases are a common problem that cancer patients may face, and currently, there are no effective drugs to t
Externí odkaz:
https://doaj.org/article/0d265cd1f57246c4854b7221da70e846
Autor:
Ruizhong Wang, Brijesh Kumar, Poornima Bhat‐Nakshatri, Mayuri S. Prasad, Max H. Jacobsen, Gabriela Ovalle, Calli Maguire, George Sandusky, Trupti Trivedi, Khalid S. Mohammad, Theresa Guise, Narsimha R. Penthala, Peter A. Crooks, Jianguo Liu, Teresa Zimmers, Harikrishna Nakshatri
Publikováno v:
JCSM Rapid Communications, Vol 4, Iss 1, Pp 24-39 (2021)
Abstract Background Loss of skeletal muscle volume and functional limitations are poor prognostic markers in breast cancer patients. Several molecular defects in skeletal muscle including reduced myoblast determination protein 1 (MyoD) levels and inc
Externí odkaz:
https://doaj.org/article/a00e580af8d34f4daa2fee42e2201e27
Autor:
Hiroaki Saito, Andreas Gasser, Simona Bolamperti, Miki Maeda, Levi Matthies, Katharina Jähn, Courtney L. Long, Hartmut Schlüter, Marcel Kwiatkowski, Vaibhav Saini, Paola Divieti Pajevic, Teresita Bellido, Andre J. van Wijnen, Khalid S. Mohammad, Theresa A. Guise, Hanna Taipaleenmäki, Eric Hesse
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Parathyroid hormone (PTH) is used to treat osteoporosis, but its therapeutic mechanism remains unclear. Here, the authors show that Tgif1 is a PTH target gene, and that its deletion impairs the function of osteoblasts and PTH-induced bone formation i
Externí odkaz:
https://doaj.org/article/e1b46a452798403ebde7a78a57d3c849
Publikováno v:
Cells, Vol 11, Iss 8, p 1309 (2022)
Metastatic bone disease is a common and devastating complication to cancer, confounding treatments and recovery efforts and presenting a significant barrier to de-escalating the adverse outcomes associated with disease progression. Despite significan
Externí odkaz:
https://doaj.org/article/42b25d0c60f3451bb4192e0a9a61bfcb
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1643 (2021)
Complications associated with advanced cancer are a major clinical challenge and, if associated with bone metastases, worsen the prognosis and compromise the survival of the patients. Breast and prostate cancer cells exhibit a high propensity to meta
Externí odkaz:
https://doaj.org/article/bcea8097de5c448abc431ca453ee68b0
Autor:
Neha S. Dole, Courtney M. Mazur, Claire Acevedo, Justin P. Lopez, David A. Monteiro, Tristan W. Fowler, Bernd Gludovatz, Flynn Walsh, Jenna N. Regan, Sara Messina, Daniel S. Evans, Thomas F. Lang, Bin Zhang, Robert O. Ritchie, Khalid S. Mohammad, Tamara Alliston
Publikováno v:
Cell Reports, Vol 21, Iss 9, Pp 2585-2596 (2017)
Poor bone quality contributes to bone fragility in diabetes, aging, and osteogenesis imperfecta. However, the mechanisms controlling bone quality are not well understood, contributing to the current lack of strategies to diagnose or treat bone qualit
Externí odkaz:
https://doaj.org/article/0fca8e4f2a204101aeb0cc7062150b19
Autor:
Peng Zhang, Caihong Xing, Steven D. Rhodes, Yongzheng He, Kai Deng, Zhaomin Li, Fuhong He, Caiying Zhu, Lihn Nguyen, Yuan Zhou, Shi Chen, Khalid S. Mohammad, Theresa A. Guise, Omar Abdel-Wahab, Mingjiang Xu, Qian-Fei Wang, Feng-Chun Yang
Publikováno v:
Stem Cell Reports, Vol 6, Iss 6, Pp 914-925 (2016)
Summary: De novo ASXL1 mutations are found in patients with Bohring-Opitz syndrome, a disease with severe developmental defects and early childhood mortality. The underlying pathologic mechanisms remain largely unknown. Using Asxl1-targeted murine mo
Externí odkaz:
https://doaj.org/article/a8fd63481cbe4c84b5d14195c86a0d88