Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Khalid N Al-Zahrani"'
Autor:
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 6, Pp 719-740 (2024)
Abstract Tumor suppressor p53 (TP53) is frequently mutated in cancer, often resulting not only in loss of its tumor-suppressive function but also acquisition of dominant-negative and even oncogenic gain-of-function traits. While wild-type p53 levels
Externí odkaz:
https://doaj.org/article/4644b709c6d143dfb92c748768749b96
Autor:
Grant A Howe, Bin Xiao, Huijun Zhao, Khalid N Al-Zahrani, Mohamed S Hasim, James Villeneuve, Harmanjatinder S Sekhon, Glenwood D Goss, Luc A Sabourin, Jim Dimitroulakos, Christina L Addison
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150567 (2016)
Blockade of epidermal growth factor receptor (EGFR) activity has been a primary therapeutic target for non-small cell lung cancers (NSCLC). As patients with wild-type EGFR have demonstrated only modest benefit from EGFR tyrosine kinase inhibitors (TK
Externí odkaz:
https://doaj.org/article/21805c1dece148209f371f94cca74a0d
Autor:
Cédrik Labrèche, David P. Cook, John Abou-Hamad, Julia Pascoal, Benjamin R. Pryce, Khalid N. Al-Zahrani, Luc A. Sabourin
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-14 (2021)
Abstract Background Breast cancer is a highly heterogeneous disease with multiple drivers and complex regulatory networks. Periostin (Postn) is a matricellular protein involved in a plethora of cancer types and other diseases. Postn has been shown to
Externí odkaz:
https://doaj.org/article/9c9e5ccf6503486ea9f67bb494f2c5be
Autor:
Khalid N. Al-Zahrani, John Abou-Hamad, Julia Pascoal, Cédrik Labrèche, Brennan Garland, Luc A. Sabourin
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-13 (2021)
Abstract Background Approximately 5–10% of HER2-positive breast cancers can be defined by low expression of the Ste20-like kinase, SLK, and high expression of SOX10. Our lab has observed that genetic deletion of SLK results in the induction of Sox1
Externí odkaz:
https://doaj.org/article/6a9ce1337d9a477fa45fa0766a28d362
Autor:
Connor Yanchus, Kristen L. Drucker, Thomas M. Kollmeyer, Ricky Tsai, Warren Winick-Ng, Minggao Liang, Ahmad Malik, Judy Pawling, Silvana B. De Lorenzo, Asma Ali, Paul A. Decker, Matt L. Kosel, Arijit Panda, Khalid N. Al-Zahrani, Lingyan Jiang, Jared W. L. Browning, Chris Lowden, Michael Geuenich, J. Javier Hernandez, Jessica T. Gosio, Musaddeque Ahmed, Sampath Kumar Loganathan, Jacob Berman, Daniel Trcka, Kulandaimanuvel Antony Michealraj, Jerome Fortin, Brittany Carson, Ethan W. Hollingsworth, Sandra Jacinto, Parisa Mazrooei, Lily Zhou, Andrew Elia, Mathieu Lupien, Housheng Hansen He, Daniel J. Murphy, Liguo Wang, Alexej Abyzov, James W. Dennis, Philipp G. Maass, Kieran Campbell, Michael D. Wilson, Daniel H. Lachance, Margaret Wrensch, John Wiencke, Tak Mak, Len A. Pennacchio, Diane E. Dickel, Axel Visel, Jeffrey Wrana, Michael D. Taylor, Gelareh Zadeh, Peter Dirks, Jeanette E. Eckel-Passow, Liliana Attisano, Ana Pombo, Cristiane M. Ida, Evgeny Z. Kvon, Robert B. Jenkins, Daniel Schramek
Publikováno v:
Science
Establishing causal links between inherited polymorphisms and cancer risk is challenging. Here, we focus on the single-nucleotide polymorphism rs55705857, which confers a sixfold greater risk of isocitrate dehydrogenase ( IDH) –mutant low-grade gli
Autor:
Khalid N. Al-Zahrani, John Abou-Hamad, Julia Pascoal, Cédrik Labrèche, Brennan Garland, Luc A. Sabourin
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/36d6a3be31bd4ba6b1ecff6a32ff164a
Autor:
Daniel Schramek, Geoffrey M. Wahl, Miguel Angel Pujana, Erik S. Knudsen, Agnieszka K. Witkiewicz, Michael D. Wilson, Hartland W. Jackson, Jeffrey L. Wrana, Therese Sørlie, David W. Cescon, Sean E. Egan, Gary D. Bader, Rod Bremner, Sampath K. Loganathan, Seda Barutcu, Thomas Nguyen, Jeff C. Liu, Masahiro Narimatsu, Daniel Trcka, Katelyn J. Kozma, Robin H. Oh, YiQing Lü, Andrew Elia, Sana Alvi, Ricky Tsai, Somaieh Afiuni-Zadeh, Samah El Ghamrasni, Helga Bergholtz, Ahmad Malik, Katie Teng, Roderic Espin, Liis Uuskula-Reimand, Minggao Liang, Zhibo Ma, Khalid N. Al-Zahrani, Ellen Langille
Systematically investigating the scores of genes mutated in cancer and discerning disease drivers from inconsequential bystanders is a prerequisite for precision medicine but remains challenging. Here, we developed a somatic CRISPR/Cas9 mutagenesis s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3e88720028d1c1acd19d4e081944a9
https://doi.org/10.1158/2159-8290.c.6549708.v1
https://doi.org/10.1158/2159-8290.c.6549708.v1
Autor:
Daniel Schramek, Geoffrey M. Wahl, Miguel Angel Pujana, Erik S. Knudsen, Agnieszka K. Witkiewicz, Michael D. Wilson, Hartland W. Jackson, Jeffrey L. Wrana, Therese Sørlie, David W. Cescon, Sean E. Egan, Gary D. Bader, Rod Bremner, Sampath K. Loganathan, Seda Barutcu, Thomas Nguyen, Jeff C. Liu, Masahiro Narimatsu, Daniel Trcka, Katelyn J. Kozma, Robin H. Oh, YiQing Lü, Andrew Elia, Sana Alvi, Ricky Tsai, Somaieh Afiuni-Zadeh, Samah El Ghamrasni, Helga Bergholtz, Ahmad Malik, Katie Teng, Roderic Espin, Liis Uuskula-Reimand, Minggao Liang, Zhibo Ma, Khalid N. Al-Zahrani, Ellen Langille
Supplementary Data from Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0b4da81cbb00416f796f44e9fdd2b9
https://doi.org/10.1158/2159-8290.22541622.v1
https://doi.org/10.1158/2159-8290.22541622.v1
Autor:
Nina Adler, Alexander T. Bahcheli, Kevin Cheng, Khalid N. Al-Zahrani, Mykhaylo Slobodyanyuk, Diogo Pellegrina, Daniel Schramek, Jüri Reimand
Mutational signatures represent a footprint of tumor evolution and its endogenous and exogenous mutational processes. However, their functional impact on the proteome remains incompletely understood. We analysed the protein-coding impact of single ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d97362c9dad78d090fb70947270a56a1
https://doi.org/10.1101/2023.03.19.533271
https://doi.org/10.1101/2023.03.19.533271
Autor:
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Ahmad Malik, Nicolas S. Gonzalez-Foutel, Carmen Florencia Suarez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N. Al-Zahrani, Zhen Yuan Lin, Ricky Tsai, Varda Rotter, Patricia Ashton-Prolla, Lucia B. Chemes, Jason Moffat, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Tumour suppressor p53 (TP53) is the most frequently mutated gene in cancer. Several hotspot p53 mutants not only lose tumour suppressive capabilities, but also function in a dominant-negative manner, suppressing canonical wild-type p53 function. Furt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b71a8a4725ba188f570cfb1571bcd4
https://doi.org/10.1101/2022.03.13.483372
https://doi.org/10.1101/2022.03.13.483372